Elliot Hershberg @ElliotHershberg
Genomics @Stanford, writing https://t.co/3XO8B8H4yG, writing/investing @notboringco elliothershberg.com San Francisco, CA Joined October 2011-
Tweets3K
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Followers11K
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Following921
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Likes9K
Instead of ripping dead organisms out of the ground, we should engineer living organisms to meet the world’s physical needs sustainably.
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Elliot Hershberg retweeted
finally finished the antibody ML primer post if you are in the protein ML field, not in antibody ML, and would like to understand antibody ML bit more, you’re my ideal audience! abhishaike.com/2024/04/15/a-p… 🧵 🧵 🧵
Niko McCarty 🧫 @NikoMcCarty
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Vega Shah @dr_alphalyrae
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Jake Wintermute 🪵 @SynBio1
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Sebastian S. Cocioba�.. @ATinyGreenCell
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Dr. Nicole Paulk @Nicole_Paulk
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Shouldn’t aging be part of drug discovery for diseases of aging? gordian.bio/blog/introduci… Gordian exists to move therapeutic testing from plastic wells and young mice into a living environment with all the complexity present in patients with age-related disease. We’re now…
San Francisco post-mortum. Tl;dr: Absolute top-tier city if you pretend downtown doesn’t exist. Literally, just never set your set a feet into the inner-city part and you’re going to have an amazing time. ❌ The bad: • Downtown (Tenderloin & SoMa) is a zombie wasteland and…
Glad that our sequence model of promoters in human genome is now published in @ScienceMagazine. Check out the paper for a deep dive into the sequence basis of transcription initiation at the basepair level: science.org/doi/10.1126/sc…
Morning run with the prime minister. Sharp change from the morning runs I have got used to over the last year🤣 It was a massive privilege to get the opportunity to run with the prime minister yesterday and poke my head around 10 Downing Street. Something I’ll enjoy telling the…
- Mine millions of CRISPR operons - Finetune a protein language model - Generate active Cas9s, including OpenCRISPR-1, with 182 mutations from the closest nature Cas9 and lower off-target rates than SpCas9 @jeffruffolo @AadyotB @MartinPacesa @alexjmeeske @thisismadani
🎉Thrilled to announce our collaboration with Regeneron with a 100MM upfront! We believe that collaborating with Regeneron is a critical step toward maximizing the impact of our technology
Introducing SF Deep Tech Week When people think of SF they think of software startups. But SFBA is also the deep tech capital of the world. Time to show off with events on bio, industrials, defense, energy, climate, space, quantum. Oh, and parties.
The Future is Being Built in the City of San Francisco SF Deep Tech Week is officially live - June 23-29th @8vc, @lowercarbon, @fiftyyears, @GiantStepVC, @Quantonation, @draper_u, and @RayyanIslam1 with 8090 Industries. Here's the main event lineup 🧵 Event submission and…
Houston, we have a problem! But also a solution 👍👍😉
Lipid nanoparticles are very inflammatory. This makes them a great vaccine adjuvant, but a difficult vector for universal delivery of nucleic acids. A recent study showed that endosomal escape—the mechanism for RNA delivery—is also the driver of this inflammation.
@ElliotHershberg Evolutionary pressure on AAVs to induce less inflammation until they’ve reached high replication levels would make sense intuitively.
@ElliotHershberg Thanks for posting this. I just started writing on this topic recently. My understanding was that AAVs are administered at higher doses due to limitations in payload capacity + stability. Also AAVs have less off-target effects compared to LNPs - but maybe that’s making the same…
@ElliotHershberg Do we need them to be living organisms? Seems like CFPS is an efficient route as well
@ElliotHershberg Couldn’t agree more. A few tweaks to the economic incentives/disincentives and this will be the path forward. Refining the goop from the ground takes huge capital investments amortized over 50 years or more. Bio-engineering produces the exact molecule you want at scale in a…
you (a gassy simpleton): consumer biotech products are years away!! me (a man of class):
There are few things as satisfying as seeing a company you've worked with for years getting the Packy treatment. Excited to have Not Boring Capital as a co-investor in @earthaiexplore!
“Everybody wants an abundant future, but nobody wants to dig no heavy-ass rocks.” Mining is a $2 trillion industry. It's eons older than prostitution & may be the last industry standing post-AGI. But new discoveries are anemic and VC doesn't touch it. Enter @earthaiexplore 🪨
“Everybody wants an abundant future, but nobody wants to dig no heavy-ass rocks.” Mining is a $2 trillion industry. It's eons older than prostitution & may be the last industry standing post-AGI. But new discoveries are anemic and VC doesn't touch it. Enter @earthaiexplore 🪨
some things I've learned from running a co writing.arman.do/p/some-things-…
First marathon in the books innit
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