Jay Bradner, M.D. @jaybradner
Physician-scientist making medicines with friends, memories with family. EVP R&D and CSO at Amgen linkedin.com/in/jaybradner Thousand Oaks, CA Joined September 2011-
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Energizing two days with the brilliant students and faculty @StanfordUChem and @Stanford_ChEMH trading insights into therapeutic modularity, molecular glues, chembio and careers. Better together. Thx for the shout-out @CarolynBertozzi, and most of all to rockstar hosts Hlib and…
Energizing two days with the brilliant students and faculty @StanfordUChem and @Stanford_ChEMH trading insights into therapeutic modularity, molecular glues, chembio and careers. Better together. Thx for the shout-out @CarolynBertozzi, and most of all to rockstar hosts Hlib and… https://t.co/yfrM5KxugQ
Delighted to see this work on the first inhibitor/degrader of the Werner Helicase (WRN), finally published. A genetically defined synthetic lethality, to be tested in the human model system of disease. Congratulations to all from NIBR who led this program. nature.com/articles/s4158…
CRBN FTW
Is there an extended cut to this interview? I could listen to @SchreiberStuart all day long.
Is there an extended cut to this interview? I could listen to @SchreiberStuart all day long.
Direct inhibition of transcription factors remains a high hanging fruit in therapeutic science, but avails a chance to rewire pathologic cell states. Just delighted to see this master class in drug hunting finally disclosed and published. So hopeful that IAG will help patients…
“Consensus changing” chemical biology at its finest, a new approach to modulating gene control. Neormorphic covalent ligands redirect the intently studied FOXA1 transcription factor, and instruct on pioneering functionality. A first TF-DNA glue? Way to go @Michael_A_Erb and Ben…
“Consensus changing” chemical biology at its finest, a new approach to modulating gene control. Neormorphic covalent ligands redirect the intently studied FOXA1 transcription factor, and instruct on pioneering functionality. A first TF-DNA glue? Way to go @Michael_A_Erb and Ben…
Congratulations, Jean-Charles on your appointment to the @AACR Board of Directors. They will so benefit from both your incisive insights into cancer medicine and total commitment to the cancer patient. #MyCompany
Congratulations, Jean-Charles on your appointment to the @AACR Board of Directors. They will so benefit from both your incisive insights into cancer medicine and total commitment to the cancer patient. #MyCompany
Real progress in colorectal cancer detection by genetic detection methods in both blood and stool, but sensitivity still lags IMO. If average risk 45 years or older, discuss colonoscopy with your PCP!
Real progress in colorectal cancer detection by genetic detection methods in both blood and stool, but sensitivity still lags IMO. If average risk 45 years or older, discuss colonoscopy with your PCP!
Killer use of dTAG to study the fast biology of PP2A. Numerous new substrates annotated.
I love this paper from @davidrliu and @eric_fischer, and further optimized ZnF tags are warmly welcome. Question for you two: in the abstract you speak to “problems with current degron tags”. Are there problems with dTAG? Seems fully orthogonal, small, insertable, works in vivo,…
I love this paper from @davidrliu and @eric_fischer, and further optimized ZnF tags are warmly welcome. Question for you two: in the abstract you speak to “problems with current degron tags”. Are there problems with dTAG? Seems fully orthogonal, small, insertable, works in vivo,…
Tomorrow’s in-flight meal just became that much meatier. Congratulations @bloodgenes, cannot wait to digest this entree.
Tomorrow’s in-flight meal just became that much meatier. Congratulations @bloodgenes, cannot wait to digest this entree.
Very cool proteomic study of defined dinucleosomes and their capacity to recruit readers and complexes. Spoiler alert: all the cool BRD4 action is in Supplemental Figure 1.
Very cool proteomic study of defined dinucleosomes and their capacity to recruit readers and complexes. Spoiler alert: all the cool BRD4 action is in Supplemental Figure 1.
Maybe the most lovely reflection on a life well lived, amidst a cancer diagnosis, that I’ve ever read. By Simon Boas. jerseyeveningpost.com/news/2024/02/1…
March 7th at 11am EDT we will have Ryan Potts of @Amgen speaking in our TPD seminar series sharing some insights on how proximity-based therapeutics has redefined druggability! Very much looking forward to this seminar!
Thrilled to kick off the 17th Annual Business of Biotech conference @MoffittNews! #MoffittBOB We are honored to have Robert Bradway, CEO @Amgen and @CathieDWood, Founder, CEO, CIO @ARKInvest joining us today for our keynotes at the conference! @jaybradner
A great morning at Moffitt’s Business of Biotech conference, kicked off with a keynote ft. Bob Bradway, CEO @Amgen. A special thank you to guest host Krystyna Kowalczyk, President and CEO of @OncoBay. #MoffittBOB @HLeeMoffitt1 @jaybradner @DrJamesMule
David R. Liu @davidrliu
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313 Followers 832 Following Studying the origin of multicellularity in animals. @StanfordBiochem 🇲🇾🇬🇧🇩🇪🇺🇸 He/himJose Vazquez-Medina @jpv_m
186 Followers 408 FollowingChih-Hao Lu @ChihHaoLu_TW
38 Followers 80 Following A Biophysicist, Cell Biologist and Chemist from @BianxiaoC Lab at @StanfordUChem. 🇹🇼🇺🇸Lindsay Guzmán @lindsaychembio
581 Followers 442 Following #firstgen college grad. BS and PhD in chem. Postdoc @Stanford in the lab of @CarolynBertozzi. She/her/ella.Yin-Hong Cao @caoyinhong
143 Followers 1K Following Postdoc in Jiayang Li Lab, Institute of Genetics and Developmental Biology, CAS. Focus on the Multi-omics of dandelions & rice🌱🌾Recruiting Top-Tier Talents👇Jay Daniels @jay_daniels1
124 Followers 225 Following passionate about building curative cell therapies | founding scientist at Moonlight Bio via NU MSTPEliot I. Behr @behr_eliot
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62 Followers 103 Following North Carolina State University Department of Chemistry Graduate StudentSiavash Moghadami @SMoghadami
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194 Followers 2K Following Organic/analytical chemist, CMC, pharm dev, drug developmentReem Al-Ahmad | ري�.. @reemalahmadd
200 Followers 418 Following PhD candidate in the Dai lab @emorychem | @umich alumnaChristina Yoon @ChrissieYoon
1 Followers 54 FollowingWill @will85881712
111 Followers 785 Following “It’s not what you see, it’s how you see it.” | Neuroscience, Data Science, AI, Environmental Tech, BiotechBrad Loncar @bradloncar
69K Followers 365 Following #Biotech, Founder of @BiotechTVHQ, KC native, @univmiami hurricane.🧬🙌David R. Liu @davidrliu
64K Followers 59 Following Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1Ingo Hartung @HartungIngo
14K Followers 780 Following MedChem @Merckgroup; drug discovery nerd in oncology, immunology & targeted protein degradation, soccer, politics or tapas can get into the way; my own viewsAdam Feuerstein ✡�.. @adamfeuerstein
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1K Followers 428 Following Husband, father, Chief of Surgical Oncology at BWH, Professor of Surgery at HMS, S.C. native, long-term Boston area residentDoudna Lab @doudna_lab
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623 Followers 2K Following A #chemicalbiology & therapeutics lab @stjuderesearch chaired by Aseem Ansari; focused on innovative chemical & #chemoinformatic solutions for #ChemToMedPeggy Goodell @Goodell_Lab
4K Followers 462 Following The Goodell Lab. Hematopoietic stem cells, epigenetics, DNA methylation. Chair, Dept of Mol Cell Biology at Baylor College of Medicine. Tweets my own.Kira Gritsman @Gritsman_lab
3K Followers 2K Following Physician-scientist investigating signaling and self-renewal in leukemia and hematopoietic stem cells. Posts are my own.The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.
We are pleased to announce that #FDA has cleared our IND application for PM359 for the treatment of chronic granulomatous disease (CGD), enabling Prime to initiate its Phase 1/2 clinical trial in the US. Details: investors.primemedicine.com/news-releases/… $PRME
A huge honour to have received the Breakthrough Prize with John Jumper for #AlphaFold. The ceremony was a wonderful and fun event, and great to see science popularised in the mainstream, hopefully it will help to inspire the next generation to get into research and science!
Congratulations to @demishassabis and John Jumper who received the 2023 Breakthrough Prize in Life Sciences for their work on #AlphaFold, an AI system to predict the 3D structure of proteins. 🧬 Find out more. → dpmd.ai/3JFJgKV
@jaybradner @StanfordUChem @Stanford_ChEMH @CarolynBertozzi Nice shoes
Congratulations Kenneth Zaret of @PennMedicine, newly inducted #NASmember! #NAS161 #biochemistry #cellbiology #medicine
Congratulations Helen Piwnica-Worms of @MDAndersonNews, newly inducted #NASmember! #NAS161 #cancerresearch #oncology
Congratulations to @MitchLazar1 (@PennIDOM), recipient of the 2025 @AAPcouncil George M. Kober Medal in recognition of his pioneering contributions to diabetes & metabolic research! tinyurl.com/48y7k47u
@jaybradner @StanfordUChem @Stanford_ChEMH @CarolynBertozzi We miss you Jay
So honored to spend my Fri afternoon witnessing a tour de force by @jaybradner !
Excited to hear @jaybradner, @Amgen CSO, deliver a student-hosted seminar @StanfordUChem. Thank you for spending the day with our trainees 🙏
Excited to hear @jaybradner, @Amgen CSO, deliver a student-hosted seminar @StanfordUChem. Thank you for spending the day with our trainees 🙏
@jaybradner Congratulations 🎊
@jaybradner We had a big dust-up in the @Nature office in 1991 about the merits and "general interest" of Mendelian linkage papers. The Werner syndrome linkage report was (I believe) the last to sneak in prior to the launch of @NatureGenet !
Dr. @kevansf’s groundbreaking scientific discovery has given HOPE to so many people living with cancer & their families. It was an honor having him at the White House! The #BidenCancerMoonshot is building a future where fear is replaced by hope.
In two independent Science studies, researchers used time-resolved crystallography at an x-ray free electron laser to capture the process of #DNA repair from picoseconds to microseconds. Learn more on #DNADay ⬇️ 📄: scim.ag/6Jd 📄: scim.ag/6Jc
GDP growth came in a bit below expectations at a 1.6% annual rate in the first quarter. But much of the slowdown was in non-inertial items like inventories (-0.35pp) and net exports (-0.86pp). The better signal of final sales to private domestic purchasers was 3.1%.
Took me 14 years to get a @OfficialWZevon reference into @RetractionWatch, but here you go.
Send lawyers, Einstein and Maugham: Authors object to @PLOSONE retraction retractionwatch.com/2024/04/25/sen…
Congrats to my better half! nejm.org/doi/full/10.10… @NEJM @VertexPharma
Congratulations to John T. Wilson Distinguished Service Professor Chuan He, who has been elected to the American Academy of Arts and Sciences! chemistry.uchicago.edu/news/chuan-he-… @americanacad @UChicagoPSD @UChicagoPME @UChicagoNews @UChicago @UCCRF
@jaybradner Last year, I took care of a young man with a rare sarcoma (Epithelioid Hemangioendothelioma ncbi.nlm.nih.gov/pmc/articles/P…) diagnosed by RNAseq showing the pathognomonic translocation and wondered it would be awesome to have a degrader of TEAD proteins… hope for future patients!
A world-class destination for a world-class city. Introducing initial designs for a new lakefront stadium. #StadiumForChicago