*** I understand the politics, but this statement gives a misleading impression ONLY the Wuhan Institute of Virology "desired" to create CoVs with a furin cleavage site. This is false. It is well known that Ralph Baric, Ralph Baric, and Ralph Baric also "desired" to do this.
*** I understand the politics, but this statement gives a misleading impression ONLY the Wuhan Institute of Virology "desired" to create CoVs with a furin cleavage site. This is false. It is well known that Ralph Baric, Ralph Baric, and Ralph Baric also "desired" to do this.
@Bryce_Nickels FCS inserted in SARS-1 (2006) but didn't increase infectivity because the glycoproteins weren't optimized for hACE2: pubmed.ncbi.nlm.nih.gov/16519916/
@Bryce_Nickels The PSEUDOTYPE VIRIONS section: "Lentiviral virions bearing the SARS-CoV S glycoprotein were generated using the HIV-1 proviral vector pNL4-3.Luc.R−E− (Connor et al., 1995)" [why didn't the DEFUSE protocol specify this vector system?]