Derek Kleinveld @derekkleinveld
MD| PhD. Anesthesiology resident @ ErasmusMC. Interested in trauma-induced coagulopathy, platelets, resuscitation, inflammation and organ failure. Rotterdam Joined November 2014-
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🪡@yourICM most liked/shared (on #SoMe) articles for 2023... 🧵6th & last post 🫀 Valvular procedures 🔓 rdcu.be/cd8nG 🫀 Cardiogenic shock 🔓 rdcu.be/cb6nH 🩸Coagulation & periop bleeding 🔓 rdcu.be/dvjCI 💨 HFNO 🔓 rdcu.be/dvjDG #FOAMcc
A massive day for UK trauma with the publication in @JAMA_current of two game-changing trauma trials: @CRYOSTAT_2 and @UKREBOATrial. Both turning points in how we understand and treat trauma patients. UK-REBOA: jamanetwork.com/journals/jama/… CRYOSTAT-2: jamanetwork.com/journals/jama/…
🦟💉IV artesunate in bleeding severe #trauma does NOT ⬇️ multi-organ dysfunction + may be associated with ⬆️ VTE TOP-ART RCT🔓#FOAMcc 🖇️rdcu.be/dhmTz With editorial on targeting inflammation (& carrying-out rigorous trials) in traumatic injury 🖇️rdcu.be/dhmT2
Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.
Coagulation & perioperative bleeding 🩸fibrinogen source/dose/time 🩸Ca++: just vs citrated blood products? 🩸PCCs/factor concentrates 🩸TXA 🩸plasma: volume or coagulation? 🩸PLTs as primary components 🩸RBCs not just DO2 🩸targeted coagulation support 🖇️ bit.ly/3VWMAGN
In this study, among patients with trauma at risk of massive transfusion, there was no significant reduction of 24-hour blood product consumption after administration of 4F-PCC, but thromboembolic events were more common. ja.ma/41CRBWW
Anti-high-mobility group box-1 treatment strategies improve trauma-induced coagulopathy in a mouse model of trauma and shock. New laboratory study by Sloos et al. #trauma #injury #bleeding bjanaesthesia.org/article/S0007-…
@oslertech @Osler_community Honoured to chat with @derekkleinveld about Trauma Induced Coagulopathy in this fascinating new podcast released on Osler today!
New podcast just released on Osler! Trauma induced coagulopathy with Derek Kleinveld osler.app.link/DQcTtCqFjxb #medtwitter #trauma #FOAMed #FOAMcc #emergencymedicine #emergencyphysician #ICU #intensivist #intensivecare #resuscitation
Really horrendous scenes of destruction in Turkey and Syria today. Hard to know what to say but wishing the best for everyone. I know UK teams are heading out to do what they can to help. Terrible.
Delighted to chat to @derekkleinveld about trauma-induced coagulopathy, haemostatic resuscitation, permissive hypotension and blood products tonight Keep an eye out for it on @oslertech / oslercommunity.com in the next few days
What a tragedy for our community: Sophie Hamada died on the 16th of August. She was an exceptional clinician and researcher with major roles at @ESICM. And for anyone of us who has been lucky to meet her, a wonderful person, we will greatly miss. esicm.org/obituary-sophi…
Nous avons l’infinie tristesse de vous annoncer le décès accidentel de la Pr Sophie Hamada, notre collègue, notre amie.C’était une lumière.Notre chagrin est immense.Nous adressons nos plus sincères condoléances à sa famille, à ses proches et à tous ceux qui l’ont connue et aimée.
Our mini-review on Trauma-Induced Coagulopathy is online. Do not miss the Supplementary Material! rdcu.be/cS6bn
Bleeding leading preventable cause of death in trauma: understand, detect, treat trauma-induced coagulopathy pivotal to improve outcomes 🩸pathophysiology 🩸diagnosis 🩸management 🩸knowledge gaps/future development DON'T miss supplementary file #FOAMcc 🖇 rdcu.be/cS6bn
Still 6 days to apply for these very interesting positions. Apply and help us to further improve platelet transfusions through system biology approaches @isth @ASH_hematology Postdoc / PI TRACK AND TRACE: system biology of platelet transfusions academictransfer.com/en/314745/post…
Great to see MODET (Multiple Organ Dysfunction in Elderly Trauma) published. 1316 critical care trauma patients enrolled across the four @London_Trauma MTCs, under the leadership of @TraumaEMC. Lots of take-homes about MODS and about elderly trauma care. journals.lww.com/aosopen/Fullte…

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