Alejandro Alen Vilas @dobleave

This play. This view. 100 days ago today. 💯🇦🇷 #FIFAWorldCup

⭕️Ante la presencia de Fauna Silvestre en Corrientes o en Chaco dar aviso a los siguientes contactos. •Corrientes Centro Aguara al 3795-048487. •Chaco Brigada de Operación Ambiental (BOA) 3624332763. Dirección de Fauna y Áreas Naturales Protegidas al 0362 4421428

@desdeelrespetok Hermosa canción! Y hermosa interpretación. Un dato: la música es de Piero y la letra de Luis Ramón Igarzábal

¿Crisis del libro o de una forma de venderlo? @MercadoLibre crece mientras las librerías físicas pierden ventas. Reuní datos durante casi dos años para analizar qué cambia en el mercado editorial argentino. Datos, hipótesis y consecuencias: germanecheverria.com.ar/venta-de-libro…

🚨 Franco Colapinto pide públicamente a sus fans que PAREN los ataques e insultos a pilotos, compañeros, mecánicos e ingenieros 🗣️ "Sé que están pensando que me están defendiendo, pero están generando lo contrario. NO me ayudan ni a mí NI A MI FUTURO" ‼️ Confirma además que decidió ALEJARSE DE LAS REDES para centrarse en su carrera y en conseguir resultados 🇦🇷 "Necesito que me ayuden a parar esto todos juntos"

#AD10S 🐐 𝙔 𝙜𝙪𝙖𝙧𝙙𝙤 𝙚𝙣 𝙢𝙞𝙨 𝙤𝙟𝙤𝙨 𝙩𝙪 𝙪́𝙡𝙩𝙞𝙢𝙖 𝙢𝙞𝙧𝙖𝙙𝙖 𝙈𝙚 𝙫𝙤𝙮 𝙚𝙨𝙥𝙚𝙧𝙖𝙣𝙙𝙤 𝙡𝙖 𝙥𝙧𝙤́𝙭𝙞𝙢𝙖 𝙟𝙪𝙜𝙖𝙙𝙖

Es el mejor de todos los homenajes que vi en estos dias. Absolutamente emocionado. La autora es @JuliaDupuy

#AD10S 🐐 🎇 Está iluminado desde que nació 🙌 🔟 Te amamos, capi 🫶

THE GREATEST OF ALL TIME. 🐐

🇦🇷🔟♾️ #FIFAWorldCup

THIS IS BIG! The Cancer Cells That Changed Their Minds A KAIST team just reversed cancer without killing a single cell — and the method may matter more than the result. For a century, oncology has had exactly one strategy: find the cancer and destroy it. Chemotherapy poisons it. Radiation burns it. Surgery cuts it out. Immunotherapy teaches the body to hunt it. Every weapon differs in precision, but not in philosophy. The tumor is an enemy. You win by killing. Now a team at South Korea's KAIST has proposed a heresy: *what if the tumor doesn't need to die?* In a study led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, published in Advanced Science ("Control of Cellular Differentiation Trajectories for Cancer Reversion," DOI 10.1002/advs.202402132), researchers took colon cancer cells and — without poisoning, irradiating, or cutting them — turned them back into normal cells. Not dead. Not damaged. Just normal again. The tumors, grown in mice, shrank dramatically. The surrounding tissue was left intact, because there was never an attack to survive. This is early research — cell lines and animal models, no human trials, real obstacles still unsolved. But the conceptual break is the story. For the first time, cancer treatment has a second verb. Not just destroy. Also: convert. The digital twin of a cell The KAIST team's insight begins with a redefinition of what cancer is. The conventional view treats cancer as a pile of broken machinery: mutations accumulate, checkpoints fail, cells proliferate. Cho's group looked at the same evidence and saw something different — a trajectory. During oncogenesis, they observed, normal cells don't just break. They regress, sliding backward along the differentiation path they followed when they matured. A colon cell becomes, in effect, a confused stem cell: immature, proliferative, lost. If cancer is a wrong turn on a developmental road, then the treatment question changes. You don't blow up the road. You build a map and find the turn. That map is what the team calls a digital twin — a complete computational model of the gene network governing a cell's differentiation. Using data from 4,252 intestinal cells, they reconstructed a network of 522 interacting components, capturing how genes regulate one another as a cell matures or degrades. Then they did the audacious thing: they asked the simulation which levers, flipped together, would push a cancer cell back down the road toward normalcy. The answer came through a system they built called BENEIN (Boolean Network Inference and Control), which models gene interactions as logical relationships and systematically tests which interventions redirect the network's state. The simulation pointed to three master regulators — the genes MYB, HDAC2, and FOXA2 — acting together as the switch that holds the cancerous state in place. Turn all three off simultaneously, the model predicted, and the cell would stop proliferating and differentiate into something resembling a normal intestinal cell. They tested it, and it worked. In three colon cancer cell lines, suppressing MYB, HDAC2, and FOXA2 together strongly induced differentiation into normal-like cells. The cancer cells began expressing markers of healthy intestinal tissue. Proliferation collapsed — not because the cells died, but because they grew up. In animal models, tumors formed from the reprogrammed cells were dramatically smaller than controls, and under the microscope they looked far more like normal tissue. The signature achievement, and the one that would matter most to any patient reading this: there was no collateral damage. Nothing was poisoned, burned, or irradiated. The healthy tissue never came under fire, because there was no fire. 1 of 2

Hoy, la santa Iglesia celebra una fiesta particular, no solo en honor a San Miguel, que es el príncipe de toda la milicia celestial, sino también en honor de los otros arcángeles más conocidos: San Gabriel y San Rafael. Estos soberanos espíritus, cuya multitud, según dicen algunos doctores, excede al número de las estrellas del cielo, fueron creados antes que todas las criaturas de la tierra. La inteligencia de los ángeles entiende sin necesidad de razonamiento y su voluntad es tan constante que, según dice Santo Tomás, nunca se aparta de lo que una vez escogió. Por eso, lo que quieren, lo quieren para siempre. En la jerarquía suprema hay tres órdenes: Serafines, Querubines y Tronos. En la segunda, hay tres coros: Dominaciones, Virtudes y Potestades. En la tercera, Principados, Arcángeles y Ángeles. Todos estos soberanos espíritus son llamados con el nombre de "ángeles" porque, como dice San Pablo, son ministros del Señor para el bien de quienes han de heredar la bienaventuranza eterna. Todos ellos están revestidos de la gracia que nunca perdieron y son la lucidísima familia de siervos que sirven a Dios y de ministros que ejecutan su voluntad soberana en el gobierno del mundo y en la particular providencia que tiene sobre la Iglesia y también sobre cada uno de los hombres, tanto fieles y cristianos como infieles y pecadores, pues todos tienen su ángel de la guarda. Por estas excelencias de los santos ángeles y por los beneficios que de sus manos recibimos, debemos honrarlos, y especialmente al gloriosísimo príncipe de ellos, San Miguel, que es el soberano protector de la Iglesia. Su nombre significa "¿Quién como Dios?", porque cuando el príncipe de los ángeles, Lucifer, envanecido por la grandeza de sus dones y gracias, se negó a adorar el misterio de la naturaleza humana tan ensalzada en la persona de Cristo y arrastró a su rebelión a muchos ángeles, el fidelísimo San Miguel defendió la honra de Dios y de su Unigénito, y con gran poder arrojó de los cielos a los ángeles rebeldes. Entonces, San Miguel fue exaltado al trono que perdió Lucifer y recibió el principado de todos los ejércitos celestiales, la representación de la divina autoridad en la tierra y la protección de la Iglesia de Cristo, a la cual defenderá de todos los poderes del mundo y del infierno hasta el fin de los siglos. Reflexión: Entiendan bien todos los católicos que la actual rebelión de los hombres que, ensoberbecidos por los progresos materiales, apostatan de la fe, no es otra cosa que una imitación de la rebeldía de los ángeles malos. Es una rebelión que Lucifer inspira a los pobres hijos de Adán para que no logren la dicha de reinar en el cielo con los ángeles buenos, sino que se condenen y padezcan eternamente con los demonios.

@bartolomerulli Si fue contra su voluntad, mi solidaridad con Thor. Más me preocupa que en la imagen Karina tenga las uñas de la mano derecha al natural y las de la izquierda en rojo sangre

I kept hearing that Pope Leo XIV was “far left,” and for a while I assumed there must be some truth to it. Then I started actually listening to him. Not clips. Not political commentary. Not somebody telling me what I was supposed to think about him. His speeches. His words. His teaching. And I have completely changed my opinion of him. On immigration, he has acknowledged that a country has the right to control its borders. But he does not stop there. He has also told immigrants that entering another country comes with responsibilities. Learn the language. Respect the laws. Learn the customs. Participate in the life of the community. That struck me because it is neither “open borders” nor a rejection of the immigrant. It is order and responsibility alongside human dignity. Then there is abortion. Pope Leo has been absolutely clear that the right to life begins at conception and continues until natural death. In his encyclical, he specifically named induced abortion and euthanasia among choices the Church considers gravely wrong. And now, as he prepares to go to France, where abortion has been placed in the constitution and assisted dying has advanced into law, the central theme of his visit is essentially a defense of human life: “That the world may have life.” (AP News) Then listen to what he tells young people. Stop being afraid of commitment. Stop being afraid of your vocation. Stop being afraid of marriage. When speaking to hundreds of thousands of young people in Spain, he congratulated couples preparing for marriage and told them plainly: “You don’t have to be afraid to get married and start a family.” In a culture constantly telling young adults to delay marriage, delay children, chase themselves first and keep every option open forever, hearing the Pope tell young people that marriage and family are something beautiful enough to embrace instead of fear hit me hard. (National Catholic Register) The more I listen to Pope Leo, the more ridiculous our political labels start to look. Borders matter. Laws matter. The unborn matter. Migrants matter. Marriage matters. Families matter. Human dignity matters. None of those things cancel the others out. That is Catholicism. I thought I had Pope Leo figured out before I really listened to him. I was wrong. And honestly, the more I hear from him, the more I love this Pope.

@juanelegonzalez El Loco va a terminar siendo Illia en la comparación final. Claro que a esa historia ya no la vamos a contar nosotros

@videmasi Por experiencia me tienta decirte que si hasta ahora no intentaron pasarte un sobre es porque saben que sos incorruptible o porque aún no les suma valor comprar tu opinión. Como sea, win-win. O no?

Vengo a pedir un favor. Pónganse un poco en el lugar de esta gente. Si tu perro estuviera perdido, querrías que todos lo compartieran. Dale Rt a Canela, lleva tiempo perdida, pero la siguen buscando porque la aman. Se perdió en Capital, pero no importa de dónde sos, compartila.