Claudia Driscoll @driscoll_cl
postdoc w/ Brian Hie @Stanford and @arcinstitute | prev DPhil @BiochemOxford @UnivCamPharm Palo Alto, CA Joined January 2021-
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it's aliiveeeeeee thank you @arcinstitute @santimillef et. al.
Excited to share this work from my PhD! See our structure below of a computationally designed IL-21 mimic with anti-tumor efficacy in mice. A collaboration between the David Baker, Stephanie & Mike Dougan, Warren Leonard, and Chris Garcia labs.
Excited to share this work from my PhD! See our structure below of a computationally designed IL-21 mimic with anti-tumor efficacy in mice. A collaboration between the David Baker, Stephanie & Mike Dougan, Warren Leonard, and Chris Garcia labs.
Over the past week, @arcinstitute published three new discoveries that I’m very proud of. • The world's first functional AI-generated genomes. Using Evo 2 (the largest biology ML model ever trained, which Arc released in partnership with @nvidia in February), Arc scientists…
Excited to share that my PhD thesis work is out in @ScienceMagazine today. We demonstrate robust rearrangement of the human genome using bridge recombinases, performing programmable insertions, excisions, and inversions at megabase-scale.
Combine multimer structure prediction and an antibody language model to design de novo antibodies with nanomolar binding affinity. @santimillef @_jnwang @talaldotpdb @driscoll_cl @haoyu_dai_dhy @Xiaowei0402 @SynBioGaoLab @BrianHie
In another preprint from the @BrianHie Lab and @SynBioGaoLab, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Great work by @BrianHie & @SynBioGaoLab labs. Looks like a big leap over SOTA with very clever bootstrapping of design & optimizing using multiple models with complementary strengths & weaknesses. Super expt. validation platform as well.
Great work by @BrianHie & @SynBioGaoLab labs. Looks like a big leap over SOTA with very clever bootstrapping of design & optimizing using multiple models with complementary strengths & weaknesses. Super expt. validation platform as well.
Still boggles my mind that we can leave frameworks as-is and only edit CDRs and still reliably get nM binders. Complete opposite of what I would have expected given how hard it is to graft CDRs from one FW to another (such as humanizing mouse mAbs). First RFantibody and now this
Still boggles my mind that we can leave frameworks as-is and only edit CDRs and still reliably get nM binders. Complete opposite of what I would have expected given how hard it is to graft CDRs from one FW to another (such as humanizing mouse mAbs). First RFantibody and now this
When structure-based models alone are too rigid and sequence-based models alone are not specific enough, put them together for a phenomenal antibody design tool!
When structure-based models alone are too rigid and sequence-based models alone are not specific enough, put them together for a phenomenal antibody design tool!
Ensembles of models are unlocking new successes in de novo antibody design, congratulations to the team! The day these experiments first worked, the lab roared like a stadium.
Ensembles of models are unlocking new successes in de novo antibody design, congratulations to the team! The day these experiments first worked, the lab roared like a stadium.
Entering my PhD, de novo antibody design was a grand challenge I thought would not be solved without huge increases in affinity data and Ab-Ag structure. Only 2 years later, we provide the first open-source recipe to get antibody binders, almost magically, out of a computer (1/3)
Entering my PhD, de novo antibody design was a grand challenge I thought would not be solved without huge increases in affinity data and Ab-Ag structure. Only 2 years later, we provide the first open-source recipe to get antibody binders, almost magically, out of a computer (1/3)
Super excited to share what we’ve been working on in collaboration with @SynBioGaoLab over the past few months on de novo antibody design. Check out this great thread by our team lead @santimillef highlighting the technical aspects of the pipeline!
Super excited to share what we’ve been working on in collaboration with @SynBioGaoLab over the past few months on de novo antibody design. Check out this great thread by our team lead @santimillef highlighting the technical aspects of the pipeline! https://t.co/MZ5eQAIPwZ
Efficient generation of epitope-targeted de novo antibodies with Germinal biorxiv.org/content/10.110… #biorxiv_synbio
Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. 🧵
Having often dealt with binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.
Having often dealt with binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target. https://t.co/5FCzKcP0bb
We may have been making a lot of progress in genome design, but we are not done with protein design just yet lol
Scientists have created the first ever viruses designed by AI, and they’re capable of hunting down and killing strains of E. coli go.nature.com/4mppvIi
New from @arcinstitute: the first functional AI-generated genomes. This is a conceptual breakthrough, but it may also unlock new strategies for combating antibiotic resistance.
New from @arcinstitute: the first functional AI-generated genomes. This is a conceptual breakthrough, but it may also unlock new strategies for combating antibiotic resistance.
Evo-designed genomes are here!! HUGE congrats to @samuelhking for fearlessly bringing this project to life. Check out the thread to learn more! ⬇️
Evo-designed genomes are here!! HUGE congrats to @samuelhking for fearlessly bringing this project to life. Check out the thread to learn more! ⬇️
Tom Knight -- e/🦀 @TomKnightSynBio
3K Followers 4K Following Engineer of stuff that is alive or computes. Follow us all to that blue place.
Radu Ticiu 🧬 @RaduTiciu
4K Followers 4K Following Tech entrepreneurship, coding, space, synbio edu-facilitator. @BioCoderDojoT founder, CoderDojo champion, @Growceanu co-founder #andacyclist Typos my own :)
willie sallie @williesallie
2K Followers 580 Following healthcare security (CHSO)⚕️| environmental observer 🌎| collaborate 👥vs👥 competition | interested in robots🤖|digital age🌐|space🌌|
Matthew Aguirre @aguirre404
573 Followers 2K Following One small analyst in a big data world. PhD student in Biomedical Informatics @ Stanford
Iqbal Hossain Nafiz @nafizz_nafiz
10 Followers 121 Following MSc in Biochemical Technology, BUET. From Bangladesh 🇧🇩. Microbiology, enzymology, protein science enthusiast.
James Michael Krieger @james_krieger
1K Followers 4K Following PhD & postdoc w @IGreger1 @MRC_LMB & @IvetBahar (ProDy) @CompBioPitt. @CSIC-@MSCActions fellow w @JM_Carazo & @COSSStock @CNB_CSIC. #Proteindynamics & #CryoEM
Yann @LeGuenYann
267 Followers 553 Following @Stanford_Neuro @stanford_qsu Deciphering the genetics causes of neurogenerative diseases.
Gita Abhiraman, MD, P... @GitaAbhiraman
1K Followers 756 Following Resident @StanfordDeptMed. Immunology, protein engineering, autoimmunity & cancer. Former Hertz Fellow, MD/PhD @Stanford, @HarvardPhysics. Views my own.
Quỳnh Tiên Đào N... @quinnkoon
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Dwauahir @dwauahir36046
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Aastha Pal @apal9_pal
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Antonio Cembellin Pri... @A_Cembellin_Pri
432 Followers 1K Following Postdoctoral Fellow @Arcinstitute | Immunologist x Synthetic Bio Enthusiast | Immigrant 🇪🇸🇺🇸 | Comms Chair @comunidadecusa | All views my own
Nathan Samuel @nathanasamuel
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CleoPatra @CleoPatra668105
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Veronica Augustina Bo... @V_Augustina14
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Sergey Ovchinnikov @sokrypton
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Adrian Garcia @adriangarcia174
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Burçin Acar @neseruzgari
777 Followers 1K Following 💻🧬Computational bio 👩🏻🔬Science 👩🏻💻Software 📖Literature 📚Books 🧠Psychology 📰Politics👩🏻🏭Feminism 🏛️History 💃🏻Dance
Alis volat propriis @Alisvolatprop12
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alex rubinsteyn @iskander
6K Followers 4K Following Genomics + immunology + ML = personalized cancer immunotherapy. @UNC_Lineberger | https://t.co/nReVwtVHPq | https://t.co/uPVUS5JFm1 | https://t.co/8DWibdfDWa
Soham Sankaran @sohamsankaran
3K Followers 5K Following I run @PopVaxIndia (https://t.co/dOKb3wZ7pr) – we develop mRNA vaccines and therapeutics using computational protein design. I write at https://t.co/reAXhjkSrU
yakuhito🌱 @yakuh1t0
2K Followers 1K Following Give a yak some chocolate and you'll make him happy for a day. Teach a yak how to use Twitter and this is what happens. | @TibetSwap @warpdotgreen
Richard Kollen @nuclearball
2K Followers 3K Following Johns Hopkins Univ., NASA, ESA, DFVLR, & SKYNET. Here for MEDICAL. I RT Doc jobs.
Dan Manastireanu @danmana
150 Followers 540 Following Full stack software developer. When I'm not working I enjoy traveling around the world. Sometimes I do both :)
Karel Krápník Berka @caco3cz
2K Followers 3K Following theoretical physical chemist and chem- and bioinformatician, Chemical data lab at @fchupol ORCID:0000-0001-9472-2589 #boardgamegeek (tweets my own) @ELIXIRCZ
Matti Pronker @MFPronker
797 Followers 949 Following Junior director at QVQ, @UniUtrecht and @MRC_LMB alumnus, EMBO LTF and Veni awardee - structural biology, #cryoEM ❄️🔬, #crystallography 🩻💎 - views are my own
Radoslav Krivak @rdkbio
776 Followers 7K Following 🧬 Structural Bioinformatics | 💊 AI/ML for Drug Discovery | Geometric DL 🔬 @IOCBPrague, prev. PhD @cusbg @matfyz
Arda Göreci @ArdaGoreci
1K Followers 560 Following AI for enzyme design | CTO at Ligo | Prev. Cell and Systems Biology @UniofOxford
Ali Farhat @alifarhat40
209 Followers 2K Following MD/PhD Candidate @uicmstp (G4) | NHLBI F30 fellow | UCLA BioEngineering alum '19 | 🇺🇲🇱🇧
Lucia Urcelay @luciaurcelayg
89 Followers 445 Following ml research scientist @ferruz_noelia lab @crgenomica | protein design | prev @novartis @bsc_cns
Pullia @emedfocus
183 Followers 3K Following
TYLER FAIR @TylerFair_
177 Followers 627 Following Scientist at @arcinstitute with Luke Gilbert & Virtual Cell Initiative
Yair Wolff @WolffYair
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RockyParadox @RockyParadox44
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LuisAlfonsoHernandez @lahpm1992
118 Followers 793 Following MD, interested in radical technologies for the betterment of humankind
RM @RM25192639
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Ashton C Trotman-Gran... @ATrotmanGrant
3K Followers 2K Following Creative Discovery @ Karyo Studios. Prev: @FiftyYears, @UofT (PhD Immunology). Co-founder, Notch Tx. Stay curious.
Charlie Harris @charlieharris01
2K Followers 1K Following AI/ML, biotech, policy, flying, sometimes in that order | SovAI Unit @SciTechgovuk | PhD @Cambridge_Uni | Prev @benevolent_ai @imperialcollege | Glider Pilot
Ran D @rlognormal
173 Followers 1K Following Software engineer with a fondness for structural molecular biology, LCMS proteomics, bio ml and llm workflows. DMs open for researcher collabs.
Tom Knight -- e/🦀 @TomKnightSynBio
3K Followers 4K Following Engineer of stuff that is alive or computes. Follow us all to that blue place.
Matthew Aguirre @aguirre404
573 Followers 2K Following One small analyst in a big data world. PhD student in Biomedical Informatics @ Stanford
Gita Abhiraman, MD, P... @GitaAbhiraman
1K Followers 756 Following Resident @StanfordDeptMed. Immunology, protein engineering, autoimmunity & cancer. Former Hertz Fellow, MD/PhD @Stanford, @HarvardPhysics. Views my own.
Aastha Pal @apal9_pal
345 Followers 902 Following PhD @penn • prev @Stanfordmed @BMSnews • @BU_tweets alum 🧬💻💊
Radoslav Krivak @rdkbio
776 Followers 7K Following 🧬 Structural Bioinformatics | 💊 AI/ML for Drug Discovery | Geometric DL 🔬 @IOCBPrague, prev. PhD @cusbg @matfyz
Matti Pronker @MFPronker
797 Followers 949 Following Junior director at QVQ, @UniUtrecht and @MRC_LMB alumnus, EMBO LTF and Veni awardee - structural biology, #cryoEM ❄️🔬, #crystallography 🩻💎 - views are my own
alex rubinsteyn @iskander
6K Followers 4K Following Genomics + immunology + ML = personalized cancer immunotherapy. @UNC_Lineberger | https://t.co/nReVwtVHPq | https://t.co/uPVUS5JFm1 | https://t.co/8DWibdfDWa
Burçin Acar @neseruzgari
777 Followers 1K Following 💻🧬Computational bio 👩🏻🔬Science 👩🏻💻Software 📖Literature 📚Books 🧠Psychology 📰Politics👩🏻🏭Feminism 🏛️History 💃🏻Dance
Nathan Samuel @nathanasamuel
786 Followers 3K Following medical doctor @ouhospitals; dphil @bdi_oxford
Veronica Augustina Bo... @V_Augustina14
196 Followers 714 Following PhD @StanfordEng @wysscoray lab, data scientist in training @stanforddata, brain & aging, equestrian youth medalist @FEI_global
Stanford University @Stanford
1.0M Followers 585 Following Our mission of discovery and learning is energized by a spirit of optimism and possibility that dates to our founding.
Antonio Cembellin Pri... @A_Cembellin_Pri
432 Followers 1K Following Postdoctoral Fellow @Arcinstitute | Immunologist x Synthetic Bio Enthusiast | Immigrant 🇪🇸🇺🇸 | Comms Chair @comunidadecusa | All views my own
Richard Kollen @nuclearball
2K Followers 3K Following Johns Hopkins Univ., NASA, ESA, DFVLR, & SKYNET. Here for MEDICAL. I RT Doc jobs.
TYLER FAIR @TylerFair_
177 Followers 627 Following Scientist at @arcinstitute with Luke Gilbert & Virtual Cell Initiative
Lucia Urcelay @luciaurcelayg
89 Followers 445 Following ml research scientist @ferruz_noelia lab @crgenomica | protein design | prev @novartis @bsc_cns
LuisAlfonsoHernandez @lahpm1992
118 Followers 793 Following MD, interested in radical technologies for the betterment of humankind
Ashton C Trotman-Gran... @ATrotmanGrant
3K Followers 2K Following Creative Discovery @ Karyo Studios. Prev: @FiftyYears, @UofT (PhD Immunology). Co-founder, Notch Tx. Stay curious.
Nathan Benaich @nathanbenaich
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Koushik @koushik_here
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Jason Kelly @jrkelly
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Sona Krajcovic @call_me_sonja
234 Followers 314 Following @springgroupchem 👩🏻🔬 @ChemCambridge 🇬🇧 | orgsyn & chembio 🧪 | minimalist 🌚 | perfectionist 🤌 | political enthusiast 🇨🇿🇪🇺
Santiago Mille @santimillef
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Aditi Merchant @aditimerch
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Lux Capital @Lux_Capital
45K Followers 18 Following We invest in emerging science and tech ventures that turn sci-fi into sci-fact. Press inquiries: [email protected].
Jason Sheltzer @JSheltzer
17K Followers 2K Following Assistant prof at @StanfordMed. Interested in aneuploidy, mitotic kinases, cancer therapeutics, and drug development. Co-founder x2.
Fay Lin, PhD @xiaofei_lin
16K Followers 1K Following Senior Technology Editor @GENBio ▪ DM me about all things AI x Bio 🧬🧪 ▪ ✉️ [email protected] ▪ she/her
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Laura S Itzhaki @LauraItzhaki
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Stanford Synthetic Bi... @StanfordSynBio
380 Followers 172 Following The official account of the Stanford Synthetic Biology community. #StanfordSB #StanfordSynBio
liugroup @liugroup
7K Followers 200 Following Official Twitter account for David R. Liu's @davidrliu research group.
Stanley Qi Lab @stanleyqilab
3K Followers 468 Following News from Stanley Qi's lab at @Stanford / @Bioe_stanford / @Stanford_ChEMH. Tweets are not from Stanley Qi unless signed SLQ.
Timothy Lu @timlu
5K Followers 785 Following Synthetic Biologist | Biotech Entrepreneur | MIT Professor
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504K Followers 1K Following Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Isomorphic Labs @IsomorphicLabs
29K Followers 75 Following We are reimagining the entire drug discovery process from first principles with an AI-first approach. Learn more: https://t.co/eC7rjmB3EZ
Sarah Gurev @sarahgurev
1K Followers 2K Following Postdoc with Debora Marks. Previously MIT EECS PhD. Starting FutureHouse Fellowship (in SF for September). Come talk to me about modeling viral/immune proteins!
Marçal Comajoan Cara @marcal_cc
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Ofir Press @OfirPress
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