Patrick Holmes @drpatrickholmes
Diabetes Advocate | AE @DiabeticMed | Med ed @goggledocs | Advisor @MHRAgovuk 🕊️ #BeKind Joined February 2009-
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Patrick Holmes retweeted
📊 Meta-analysis of 10 GLP-1RA RCTs · ↓ MACE by 14% · ↓ HF hospitalisation + kidney outcomes 👉 Glycaemic control, not weight loss, associated with CV benefits of GLP-1RAs pubmed.ncbi.nlm.nih.gov/40926380/
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Patrick Holmes retweeted
Really proud of @nicmiln launching her book Oxford Handbook of Diabetes Nursing A must read!
Patrick Holmes retweeted
Patrick Holmes retweeted
@SABOURETCardio @pabeda1 @ADA_DiabetesPro ❗️and the results❗️ 🔹non-inferiority of Tirzepatide to Dulaglutide 🔸Superiority thresholds NOT met 🔹Great all cause mortality separation
Patrick Holmes retweeted
❗️Bright and early for SURPASS-CVOT … and it looks like a crowd is building!#EASD2025 @EASDnews @AmarPut @drpatrickholmes @kamleshkhunti Follow this thread for the updates for this cardiovascular outcome trial for Tirzepatide! 👇
Patrick Holmes retweeted
20 years in 2 mins! Excellent summary of incretin development by @ArodaMd 🙌🏽🙌🏽 #EASD2025 @EASDnews @AmarPut @drpatrickholmes @kamleshkhunti
Patrick Holmes retweeted
❗️REDEFINE-2 results presented #EASD2025 ❗️ 🔹Cagrilintide 2.4mg/semaglutide 2.4mg in those with T2D 🔸Good mix of M:F and ethnicity 🔹mean BMI 36, mean age 56, mean Hba1c 8% 🔸13.7-15.7% wt loss with 1 in 3 achieving Atleast 20% weight loss ❗️ 🔹Improved TIR, normoglycaemia and…
Patrick Holmes retweeted
Patrick Holmes retweeted
Breakdown of SOUL results by baseline Hba1c and BMI #EASD2025 🔹Greater response at higher Hba1c 🔸 Similar effects regardless BMI So… less about magnitude of BMI for effect once raised 🤔 glycaemia still relevant @AmarPut @drpatrickholmes @dr_amritlamba @kamleshkhunti…
Patrick Holmes retweeted
Patrick Holmes retweeted
❗️Higher dose GLP-1…. Worth the STEP UP?❗️ Once-weekly semaglutide 7·2 mg in adults with obesity 🔸7.2mg vs 2.4mg vs placebo 🔹mean age 47yrs, mean BMI 39.9 🔸-18.7% vs -15.6% vs -3.9% change in body weight 🔹almost half on 7.2mg achieved 20% weight loss 🔸5.4% permanent,…
Patrick Holmes retweeted
💡 “If you are depressed, you are living in the past. If you are anxious, living in the future” Laozi Born 601BC 🔥My latest @Medscape Medical Mentor podcast is live 🚨Identifying & Managing Health Anxiety in Primary Care On @ApplePodcasts @Spotify & link 👇🏾
Patrick Holmes retweeted
It’s taken only a few months for the #ObesityPlan to unravel A reflection back to what I said in May 25 via @bmj_latest @DrSdeG @kamleshkhunti bmj.com/content/389/bm…
It’s taken only a few months for the #ObesityPlan to unravel A reflection back to what I said in May 25 via @bmj_latest @DrSdeG @kamleshkhunti bmj.com/content/389/bm… https://t.co/LYFSt4b0fo
Patrick Holmes retweeted
New @TheLancet Meta-Analysis by #NelsonWang @BrighamWomens HF Fellow What is the expected BP lowering with various antihypertensive regimens? Robust model derived from n=104,176 pts across 484 RCTs Terrific user-friendly tool: bpmodel.org thelancet.com/journals/lance…
Patrick Holmes retweeted
#HISTORI Trial🧠💉 Semaglutide in Schizophrenia, Prediabetes & Obesity 🔸30-week RCT (n=154, Denmark) in antipsychotic-treated patients: ⤵️HbA1c 0.46% 🩸81% 🎯normoglycaemia (<5.7%) vs 19% placebo ⤵️Weight 9.2 kg ⤴️Physical QoL 😊 No worsening of psychiatric symptoms ⚠️ GI…
Patrick Holmes retweeted
🔥Metformin & #SGLT2i for almost all in draft @NICEComms #T2D guidance! ⚠️But no drug is without harm & we must balance the benefits against possible adverse effects 💡Have a look at my @YouTube videos for people living with #T2D considering #SGLT2is youtube.com/@DrKevinFernan…
Patrick Holmes retweeted
Patrick Holmes retweeted
My latest @Medscape Medical Mentor podcast is live! 🔶What is Type 3c Diabetes?🔶 🎯Type 3c diabetes is diabetes associated with any disease, trauma, or surgery of the exocrine pancreas, and it's often misdiagnosed as #T2D Link in comments 👇🏾 Also on @Spotify & @ApplePodcasts
Patrick Holmes retweeted
❗️ATTAIN-1 topline results announced ❗️ investor.lilly.com/news-releases/… 🔹almost 60% achieving 10% weight loss (we’ve moved beyond the 5% target now😁) with higher dose 🔸-12.4% change body weight with higher dose - rivals many injectables 🔹small molecule oral tablet - could open up…
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