Rashim sharma @dwnbird
pathology PGY-6 hanging by a thread with a million dreams in heart India Joined January 2010-
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2. So path trainees – remember: Kertain+ spindle cells even if deep in the pleura ≠ mesothelioma. In fact, these reactive cells can be positive for mesothelial markers (WT1, calretinin). The degree of keratin staining is variable - this is one of the strongest I've seen
#Breastpath Breast pathology 101: Let’s take a look some intraductal proliferative lesions, and decide what to call them. Random section from a prophylactic mastectomy, 45 y/o female: @LuisBlancoJrMD @RoncinMD @LizaMQuintana @ADamronMD @TheKarenPinto @DrGeeONE @jennpincus
50 y/o F with chronic diarrhea Colonoscopy was normal Random biopsies taken. Dx? #pathagonia #pathx #gipath #gastroenterology #medstudentx #medicalstudentx #endoscope #colon #colonoscopy #pathology #bowel #colorectal #medx #medicine
PATH TWEETORIAL 1/6: To continue on with cartilaginous tumors of the bone- CHONDROSARCOMA (CS). 2nd most common malignant bone tumor. Large, infiltrative tumors in the central skeleton/pelvis/shoulder girdle/prox long bones of older pts. #PathTweetAward #HYPath #IHeartPathology
Ramen Noodle Sign of @EHFultonMD. Wavy spindle cells & collagen (like instant ramen) = tendon/fascia (dense regular connective tissue) or fibroblast/myofibroblast NOT nerve or neural tumor (contrary to conventional #pathology wisdom!). My video explains: buff.ly/2ZN98MP
Intracholecystic papillary neoplasm: 🌵Gallbladder counterpart of pancreatic IPMN. 🌴Needs thorough sampling to rule out invasion (I do total embedding), which is the most important point. 🌿Can show adjacent flat dysplasia (sample that too!). (1/2)#GiPath #GrossPath #Pathology
When you see, MICROVASCULAR PROLIFERATION, think of a high grade glial neoplasm. It's multilayered endothelia within vessels and sometimes it can even look glomeruloid! Remember, just because you see this, does not automatically make it glioblastoma. It can also be seen in 👇
Round dermal nodule consisting predominantly of clear tumor cells with voluminous cytoplasm. Histiocytes, or metastatic clear cell carcinoma (maybe renal cell?), or what? As it turns out, this was a case of melanoma. It is true when people say melanoma can look like anything,…
Be humble. Be teachable. The universe is bigger than your view of the universe. There's always room for a new idea.
Urothelial Carcinoma = A or B? #GUPath #PathTwitter #PathResidents
1/ Diagnostic excision of a BI-RADS 3 lesion... What would be you dx? Additional images i the thread 👇👇 #pathology #breastpath
Reactive lymphocytes or Downey cells in viral infections 🩸💉🤕🔬🦠 #haematology #hemepath #PathTwitter #pathX #MedTwitter #MedEd #pathology #hematopathology @ArvindKhanijo @premcharles
Glomangiopericytoma is an uncommon tumor of perivascular myoid differentiation with hemangiopericytoma-like vasculature. #surgpath #pathX #pathtwitter #pathology #pathologists #ENTpath #BSTPath
It is often a challenge when you get frozen sections from soft tissue sites, especially when they show chondro / cartilaginous morphology. #surgpath #pathX #pathtwitter #pathology #pathologists #sarcoma #cancer #BSTPath
Gastroblastoma is a GLI1 (or EWSR1) translocation tumor that one reads in textbooks but may never encounter in practice. Surely I haven't seen another one since I graduated. #surgpath #pathX #pathtwitter #pathology #pathologists #stomach #cancer #GIpath
#slidearchiveseries mixed epithelial and stromal tumor of kidney #gupath #pathtwitter #pathoutpic 🚺 middle-aged, often with long term hormonal treatment E➡️ cysts lined by bland flat/hobnail/cuboidal/columnar cells S➡️ fibrous to cellular "ovarian-type" stroma (ER+/PR+)
What is the most common ALK immunoreactivity pattern for inflammatory myofibroblastic tumor? A)🔬pathology.med.umich.edu/slides/oldfilm… B)🔬 pathology.med.umich.edu/slides/oldfilm… C)🔬 pathology.med.umich.edu/slides/oldfilm… D) All or none #BSTPath #GIPath #BreastPath #DermPath #MolPath #Pathology #PathResidents #PathTwitter
5/ Typical cystitis glandularis (CG) is caused by chronic inflammation. 6/ Intestinal metaplasia (IM), a subtype of CG, is a precursor for bladder adenocarcinoma. 7/ They have different immunophenotypes: CG: CK7✅/CK20❌/CDX2❌ IM: CK7❌/CK20✅/CDX2✅ nature.com/articles/38006…
Jerad Gardner, MD @JMGardnerMD
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659 Followers 351 Following Asst Professor, Anatomic and Neuropathology at University of Maryland SOM (@UMPathology) || Come by way of @UMiamiMedicine @WUSM_Pathology and @EmoryPathologyA wicked epithelioid angiosarcoma has burrowed into the gastric mucosa and mimicked an adenocarcinoma.
Goblet cell Adenocarcinoma #gipath #frcpath #histopathology
Carcinomas generally demonstrate specific staining patterns based on the epithelial type and differentiation status. CK7 and CK20 stains may be helpful during the workup of a primary tumor. However, tumor-specific markers help "put the nail in the coffin" in making a diagnosis.
2. So path trainees – remember: Kertain+ spindle cells even if deep in the pleura ≠ mesothelioma. In fact, these reactive cells can be positive for mesothelial markers (WT1, calretinin). The degree of keratin staining is variable - this is one of the strongest I've seen
Some cases are so classic that I am tempted to post just one image! See, liver pathology is not so bad after all
70+ Male, face Incredibly RARE example of TRUE infundibulocystic Basal cell carcinoma🤩. #dermpath #dermtwitter #pathtwitter #pathresident #dermatologia #dermatology #dermatologist #pathologist #histopathology #surgpath #dermatopathologia #dermatopathology #dermatopathologist
🔬 This week's #DailyDx theme: Prostate #Pathology ➡️ One of these things is not like the other! Can you tell which image is different from the others? ➡️ We’ll tweet the answer and some quick facts tomorrow! #UMichPath #GUPath
Ok Everyone has been sharing some great and tricky cases. Now it’s time for me to play an equally tricky game of too close too diagnose. This is all you get for now. Here’s 400x #dermpath #tooclosetodiagnose
A Review of Focal Segmental Glomerulosclerosis Classification With a Focus on Genetic Associations buff.ly/3Uf3Sym
#GUpath nephrectomy: clear cell RCC with tumor cell necrosis ✔️BAD prognostic indicator (numerous studies; I just picked one📷to show)
Cemento-ossifying fibroma of the head and neck region is a benign tumor that is usually well-circumscribed. #surgpath #pathtwitter #pathology #pathologists #ENT #Oralpath
Pathology Pearls: 🧩Sharpey's fibers - collagen fibers projecting radially from spheroidal bone deposits 👉Cemento-ossifying fibroma #pathology #PathTwitter #headandneckpath #ENTpath
Cemento-ossifying fibroma of the maxilla, 8 year old boy. #path #macroscopy #Pedipath #pathTwitter
IDH can help neuropathologists determine if tumor is Glioblastoma v. (Astrocytoma or Oligodendroglioma) Isocitrate Dehydrogenase (IDH) 1 and 2 mutations lead to gain of function and produce an oncometabolite. IDH mutation will thus be POSITIVE on IHC (1/) #pathagonia
A good illustration of Adult/Post-infantile Giant Cell Hepatitis. Multiple etiologies for this pattern: autoimmune, viral (including HEV, EBV) and drugs!! PMID: 37092012 #PathTwitter #Pathology #Liver #GIPath
60F stomach, submucosal lesion, diagnosis? A) Gastrointestinal stromal tumor B) Plexiform fibromyxoma C) Inflammatory myofibroblastic tumor D) Inflammatory fibroid polyp #GIPath #BSTPath #Pathology #PathTwitter #PathX
Fascinating! 🤩 3 yr old female, “skin tag” base of ulnar edge of little finger. Structure of an accessory digit! #dermpath #dermtwitter #pathtwitter #dermatologia #dermatology #dermatologist #histopathology #surgpath #dermatopathologia #dermatopathology #dermatopathologist