Dr Elías Sigüenza @esig526

@ForPittsSake I had to leave. After finishing my PhD it was virtually impossible to do science, other than forestry and conservation, in New Zealand. I miss home and I wish I could do what I was able to do in the UK for my country. I would love to come back, but it’s career wise impossible.

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Dr Elías Sigüenza @esig526

2 years ago

@SkunkSizzle @CnsprtrlRprt That actually sounds good 😂😂😂

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Dr Elías Sigüenza @esig526

2 years ago

@BellBeakerBloke No, you're right. Just trying to understand cancer. Such an insignificant disease. 🥳

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Dr Elías Sigüenza @esig526

2 years ago

@WesleyTheChad @LeoMars75 No they wont. I have a Ph.D. in applied mathematics and currently conduct cancer research (UK). A McDonalds employee in California earns more than me for less work.

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Dr Elías Sigüenza @esig526

2 years ago

@mikecosgrove This is exactly what the Blackrock outlook report said 😂

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Dr Elías Sigüenza @esig526

3 years ago

@seb_math_bio @BTA_Birmingham Congratulations mate! All the best! 👊

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Dr Elías Sigüenza @esig526

3 years ago

@DiracDel @maxkeiser Oof

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Dr Elías Sigüenza @esig526

3 years ago

@omaclaren This is super cool bro!

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Dr Elías Sigüenza @esig526

3 years ago

5/ We created a unique method we call "phenotype tuning”. It relies on stable isotope labeled glucose and glutamine data to obtain an accurate metabolic "flux map" of the cancer cell. This "flux map" is then translated as constraints on the #mathematical model. 🧑‍🔬👩‍🔬

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Dr Elías Sigüenza @esig526

3 years ago

4/ We made it our mission to create a maths model "blueprint" that aims to provide game-changing predictions for multiple myeloma. The model is a state-of-the-art computational tool that dissects #cancer metabolism at a #genome-scale. 🧬💻

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Dr Elías Sigüenza @esig526

3 years ago

1/ 🔬Research alert @tennantlab! Did you know that some types of cancer cells not only reshape their own metabolism but also freeload off of non-cancerous cells? Why do they do this, and why does it matter? Answering these questions could unlock potential therapeutic targets! 🧵

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Dr Elías Sigüenza @esig526

3 years ago

@IMSR_UoB 14/ Read all the juicy details here: journals.plos.org/ploscompbiol/a…

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Dr Elías Sigüenza @esig526

3 years ago

13/ Two decades have seen a revival in cancer metabolism research. Our work is proof that #Multidisciplinary workflows that integrate bench-side research with maths modelling supercharge the accuracy and predictive power of scientists to one day #EndCancer 🧬🔍🔬. @IMSR_UoB #CRUK