Greg Ippolito @gcippolito
Associate Professor Texas Biomed Immunologist San Antonio, TX Joined October 2018-
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Very nice work from the @WardLab1 : Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM science.org/doi/10.1126/sc…
McDaniel, Voss, Ewer, Ippolito et al. @VaccineTrials @txbiomed examine the molecular features of the antibody response to the R21/Matrix-M #malaria #vaccine in malaria-naïve volunteers, offering insights into the basis of vaccine efficacy. hubs.ly/Q03z5f0c0
The 17 fired members of ACIP, including me, have written an article in JAMA about our experience and our concerns. jamanetwork.com/journals/jama/…
Our new study shows that the recombinant influenza vaccine (RIV4) outperforms others by boosting higher-affinity IgG antibodies with broader protection against H3N2 strains. A win for multivalent HA immunogens in seasonal flu defense!🧬💉 #VaccinesWork thelancet.com/journals/lanmi…
Here we present the first molecular-level report of the antibody-mediated immune response to the recently licensed R21/Matrix-M malaria vaccine. Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine biorxiv.org/content/10.110…
Everything you ever wanted know about antibody feedback and immunological imprinting* …*but were afraid to ask. @_voss_w_ @JasonJ_Lavinder cell.com/cell-reports-m…
It is time for a new approach to infectious disease innovation that incentivizes solving the most pressing health issues of our day. @txbiomed Pres/CEO Larry Schlesinger lays out solutions to the big problem in @TexasMonthly texasmonthly.com/sponsored/bird…
Origins and diversity of pan-isotype human bone marrow plasma cells biorxiv.org/content/10.110… Work by Gaspar Pacheco in the lab illuminating interesting insights into antibody producing cells in human bone marrow, including elusive ones that make IgE, responsible for allergy.
#NIAID researchers identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored “dark side” of the neuraminidase protein, which could lead to new countermeasures against #flu. go.nih.gov/2Lb9nnn #NIAIDVRC
Excited to share our new antibody sequencing tools for proteomics data in Stitch. We implemented a mass-based alignment algorithm to improve sequence assembly. Check it out! github.com/snijderlab/sti… github.com/snijderlab/ali… biorxiv.org/content/10.110…
SC27 is an absolute star. pinatafarm.com/p/f83adbf6-10c… If you are a sarbecovirus and you have to encounter SC27, I hope you've got a will, because this antibody is your reckoning. Apparently embecoviruses (OC43) and merbecoviruses (MERS) are exempt from its wrath.
Can we design #COVID19 vaccines that are largely insensitive to viral evolution? Find out by reading our @biorxivpreprint preprint Led by @0327jimin @HHMINEWS @UWBiochemistry 1/22 biorxiv.org/content/10.110…
Promising results for a third PreF-based RSV vaccine: nejm.org/doi/10.1056/NE…
#AMR is a silent pandemic and new tools are needed to treat and prevent bacterial infection. In our latest work, we have identified human monoclonal antibodies able to kill Gonococcus, a bacterium resistant to almost all class of antibiotics. Check it out: biorxiv.org/content/10.110…
Is imprinting impacting immune responses to the recently updated XBB.1.5 spike (S) #COVID19 booster? Find out by reading our preprint or this thread! Led by @aletortorici @HHMINEWS @UWBiochemistry 1/18 biorxiv.org/content/10.110…
Check out our latest #influenza immunogen design efforts led by the amazing @DanaThornlow in collaboration with @faeznm and @lingwoodlab! @HarvardMicro @ragoninstitute @harvardmed biorxiv.org/content/10.110…
Exciting new bioRxiv pilot with @Science_Cast: AI-generated paper summaries at 3 levels (general -> expert) to increase accessibility. Click Automated Services in the dashboard to view these. It's a pilot experiment, tweaks to come. We value feedback 😊 connect.biorxiv.org/news/2023/11/0…

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