Genetics 201 @genetics201

"We’re spending time in the kitchen of a science building on the campus of Indiana University, where they prepare food for a tiny organism that supports genetic research around the globe: Drosophila melanogaster." indianapublicmedia.org/eartheats/food…

In Drosophila, "string", "thread", and "frayed" are all genes.

Bryan C Mounce @bryancmounce

6 years ago

Model organisms are important. So I made a yarn model of a model organism. Next I'll make a C. elegans model since all model organisms are great. 😉

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Bacterial google doodle: "Intrigued by yogurt’s reputed health benefits, Grigorov [...]finally found the rod-shaped microorganism that causes yogurt’s fermentation... later renamed Lactobacillus bulgaricus in honor of Grigorov’s home country." google.com/doodles/dr-sta…

Dehydrating and recovering C. elegans. Do not try with mice. (from doi.org/10.1534/g3.120… )

A memoir of Brenner was just published: royalsocietypublishing.org/doi/pdf/10.109… "...talking almost incessantly, coffee cup in hand and smoking. His wicked humour might be vicious, but mostly interesting or amusing. As he spoke, he emphasized even small points by raising his enormous eyebrows..."

C. elegans is part male, part female over time - but Drosophila gynandromorphs do it at the same time (see below). The bird and butterfly versions were in the NYT recently: nytimes.com/2019/02/09/sci… nytimes.com/2019/02/25/sci…

Bryan C Mounce @bryancmounce

6 years ago

Model organisms are important. So I made a yarn model of a model organism. Next I'll make a C. elegans model since all model organisms are great. 😉

6 6 156 0 5

Bacterial genetics in the news today You can sing along: "Who would have thought that the microbe that gave us Cas9, S. pyogenes, the source of strep and flesh-eating disease, housed this marvelous machine" youtu.be/k99bMtg4zRk

"Ms. Marks saw a glaring need for skilled counselors who could explain genetics in plain language to patients, listen with empathy and guide them through a complex web of emotional, ethical and legal choices." nytimes.com/2020/10/02/hea…

"It's hard to explain what it means to know I'm not the only one out here in the world." nytimes.com/2020/09/28/sci…

"Genome of Alexander Fleming’s original penicillin mold sequenced" Fleming's original anti-bacterial mold isolate had been stored away, and industrial antibiotic production uses a strain from moldy US canteloupes sciencefocus.com/news/genome-of…

"The team discovered that the resulting [drug] resistant yeast had alterations in... heterochromatin, which silences or inactivates underlying genes, causing resistance as a result of this epigenetic change." ed.ac.uk/biology/news-e…

Next model organism to add to the collection! #sciart

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"Those natural super-yeasts are living witnesses of brewing from pre-industrial ages, adapted to harsh conditions of fermentation of the strong Trappist beers, or survival in the long lagering typical for Gueuze beers." sciencedaily.com/releases/2019/…

A simple tool to help you think about Mendel's peas and the meaning of p-values. Can YOU pick enough peas to avoid a spurious p<0.05? heimanlab.com/peavalues

A good website about dog coat color genetics: doggenetics.co.uk Detailed discussion of epistasis in labrador retrievers: doggenetics.co.uk/breeding.htm Cute pictures of dog noses and the underlying genetics of nose color: doggenetics.co.uk/noses.html Tag yourself, I'm #8.

Welcome to Genetics 201! We will miss seeing you in person, but we will take advantage of opportunities to do things we couldn't have done in the classroom. Please email us early and often to let us know how the course is going and your ideas. We want to hear from you!

Should we start with complex traits in natural populations, instead of Mendelian traits in peas? nytimes.com/2019/12/07/us/…

Halloween zebrafish embryos

Adam Cohen @AdamEzraCohen

7 years ago

Happy Halloween! World's smallest fish-o-lantern? Four zebrafish embryos expressing a photo-activated fluorescent protein, patterned activation via a digital micromirror array. Credit: Harry McNamara.

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A great application of Drosophila!: businessinsider.com/flyingspark-fo…

Drosophila: I love you. Finally face to face.. .....with our first fully dressed 3D-printed fruit-fly, with swappable genotypes. With my amazingly brilliant collaborators Joaquin Villa @Juako and Parastoo Jashmidi @ParastooJamshi2 Thank you @UOBengage @BBSRC. What do u think?

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