Ornob Alam @genomeinquirer
Population genetics, rice domestication, herbarium specimens. PhD candidate in @LabPurugganan, @NYUBiology. Science writer @icddr_b. New York City Joined September 2018-
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simulation has been a critical tool for population genetics for some time so it's great to see two recent preprints dealing with some of its thornier issues when using forward in time models
We introduce an ARG-inspired data structure Genotype Representation Graph (GRG) to enable lossless data compression, efficient computation through graph traversal. Developed a fast inference method. Cost ~80 GBP to convert 350TB VCF (200,000 UKBiobank WGS) into 160 GB GRG.
We introduce an ARG-inspired data structure Genotype Representation Graph (GRG) to enable lossless data compression, efficient computation through graph traversal. Developed a fast inference method. Cost ~80 GBP to convert 350TB VCF (200,000 UKBiobank WGS) into 160 GB GRG.
New paper from the lab! Epigenetic silencing of transposons is widely considered a good resolution of host-TE conflicts, but is it? Especially, we showed that this silencing could lead to harmful local enrichment of repressive marks, even in genes (Huang et al. 2022 eLife). (1/5)
New paper from the lab! Epigenetic silencing of transposons is widely considered a good resolution of host-TE conflicts, but is it? Especially, we showed that this silencing could lead to harmful local enrichment of repressive marks, even in genes (Huang et al. 2022 eLife). (1/5)
Why do transposons jump at highly variable rates, and what does that mean to host evolution? In this @AnnualReviews, @texasrulz1, @kweiosis, Yuheng, and I integrated classic pop gen theories and new empirical data to explore this long-standing question. annualreviews.org/content/journa…
New Perspective: "Are cereal grasses a single genetic system?" rdcu.be/dErWS 30 years of genetic and genomic research in cereal crops. Genome sequences have revealed common evolutionary patterns and differences between species and will support applications in breeding.
At last, my work with @pastramimachine on a quantitative genetics model of background selection in humans is live at PLoS Genetics! journals.plos.org/plosgenetics/a…
How does selection from environmental gradients influence the eco-evo dynamics of range expansions? With @rangelimits, we use the experimental evolution of duckweeds to test some theoretical predictions on expansion speed. Out now in @Ecology_Letters! onlinelibrary.wiley.com/doi/full/10.11…
I am so excited to share the advance online version of our new paper "Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?" academic.oup.com/evolut/advance…
We are delighted to share our work on a robust, accurate method for sampling genome-wide genealogies (aka ARGs) from the full posterior distribution. This is a product of years of hard work by @YunDeng5, who is jointly advised by @ras_nielsen and me. doi.org/10.1101/2024.0… 1/n
Estimating evolutionary and demographic parameters via ARG-derived IBD biorxiv.org/content/10.110…
Haha et al. 2023: "Urbanisation generates multiple trait syndromes for terrestrial animal taxa worldwide" via @NatureComms nature.com/articles/s4146…
Apparently, while studying for the midterm, my students memed my class. 💀 credit: @wrboohar
#PeerReview from @eLife of 👉🏿 Next-generation inference of past population history by integrating diverse types of genomic markers biorxiv.org/content/10.110… #biorxiv_evobio #reviewedpreprint
Ok look, there just isn't any good evidence of transgenerational epigenetic inheritance being caused by trauma in humans. I'll wager $200 — show me good causal evidence (we can pre-negotiate terms) and I'll pay you if you prove me wrong. So why is this making it into Science?
Thread about a new preprint from the lab, led by Logan Whitehouse and Dylan Ray, about tree-sequences. The teaser tagline: why use tree sequences for evolutionary inference when you can directly examine population genetic alignments? biorxiv.org/content/10.110…
How do scaling laws at the single-cell level give rise to macroecological patterns? We show that in plankton, power laws of nutrient uptake and grazing shape eco-evolutionary dynamics to produce scaling relationships at the ecosystem level. 🌊 science.org/doi/10.1126/sc…
Scaling the fitness effects of mutations with respect to differentially adapted Arabidopsis thaliana accessions under natural conditions biorxiv.org/content/10.110…
Very happy to announce the release of my newest manuscript with Katie Lotterhos @Northeastern ! (1 / n)
Only ten years in the making!! Just preprinted a global analysis of climate change impacts on 100+ zoonotic and vector-borne diseases: tinyurl.com/ypsbcfja with the wonderful @ProfKateJones @roryjgibb
Registration is now open for the 2024 New York area Population Genetics meeting, organized by @bendesky. Keynote talks by @lindymcbr and @CedricFeschotte. At Columbia U, May 17, 2024. Register (free) and submit abstracts for talks or posters here: zuckermaninstitute.columbia.edu/new-york-area-…
Harmit S. Malik @HarmitMalik
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247 Followers 775 Following Postdoc studying mutations @Columbia Previously @ENS_ULMTetough @tetough96971
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450 Followers 4K Following It is a pleasure to invite you to the 13th International Conference on Biotechnology on June 27-28, 2024 in London, UKROTO-RUB @RotoRub
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951 Followers 5K Following Enthusiastic publisher on research of increasing rice production and value for the poor and to help rice farmers in adapting to climate change.Vince Buffalo @vsbuffalo
15K Followers 2K Following Evolutionary genetics postdoc @UCBerkeley ♥s biology, running, probability+statistics, 🦀, fly fishing, backpacking. Author of book Bioinformatics Data SkillsHarmit S. Malik @HarmitMalik
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12K Followers 3K Following evolutionary genomics of maize. erstwhile ethnobotanist. purveyor of bad puns. dad. not a cool cow from 1994 (he/him) @[email protected]Michael Eisen @mbeisen
77K Followers 15K Following I science & try to make science open. Tweets do not represent my employer's views, but are always correct. My conflicts of interest https://t.co/bZ7I9oSJe0.Sevinç Ercan @ErcanLab
1K Followers 1K Following Associate Professor of Biology at NYU. Chromatin structure, SMCs, condensin, gene regulation, X chromosomes.Prof Richard Buggs @RJABuggs
4K Followers 3K Following Senior Research Leader (Plant Health and Adaptation) @KewGardens & Professor of Evolutionary Genomics @QMULNew Phytologist @NewPhyt
45K Followers 1K Following Publishing, promoting and supporting rigorous plant science and its applications since 1902. Owned by the New Phytologist Foundation (https://t.co/0rmC4dxVNc).plantevolution.bsky.s.. @PlantEvolution
23K Followers 706 Following Weigel Lab aka WeigelWorld Retweet≠endorsement @MPI_Bio #OpenScience COIs https://t.co/9ZniwHb9c1 GoogleScholar https://t.co/shbRsjfyPRMatt Rockman @wormsrock
2K Followers 1K Following Evolutionary zoologist & quantitative geneticist @wormsrock.bsky.socialLior Pachter @lpachter
44K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatterSimon J Greenhill @SimonJGreenhill
4K Followers 2K Following I study how languages and cultures evolve. Primarily with phylogenies and other assorted computational methods. Based at @Biology_UoA. Also @[email protected]Jenn Coughlan @Jenn_Coughlan
4K Followers 3K Following All things evolutionary genetics. Mimulus fanatic, will tolerate flies. Assistant prof @ Yale EEB Non-binary. They/she 🇨🇦🏳️🌈🏳️⚧️ https://t.co/Lur4VEZ1u7Julia Kreiner @jmkreiner
2K Followers 1K Following Postdoctoral Fellow @ubcbiodiversity. Incoming Ass. Prof @uchicago. Population genomics of contemporary adaptation 🌱 She/her.Moi Expósito-Alonso .. @MExpositoAlonso
6K Followers 2K Following Researching from mutations to climate change • Prof at @UCBerkeley @Cal + Freeman Hrabowski Scholar @HHMInews • In 💚 w California 🌲🌱 🌵• ✊🏾🏳️🌈 💔🇮🇱🇵🇸Rebekah Rogers @evolscientist
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953 Followers 248 Following The 29th European Meeting for PhD Students in Evolutionary Biology, coming to near Vienna 03 - 07 June 2024!Microbiology @X_Microbiology
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4K Followers 284 Following Official feed of the Museum of Comparative Zoology, a private center for research and education at Harvard University. Exhibits of MCZ specimens @HarvardMuseumThe Plant Cell @ThePlantCell
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3K Followers 3K Following ROTO Research Group• The Return of the Organism in the Biosciences: Theoretical, Historical, & Social Dimensions 🇩🇪🇲🇽🇦🇷🇫🇮🇺🇸 #PhilSci #PhilBio #HistSTMThe Interested Layper.. @LeniDiamond
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311 Followers 1K Following @SaveFruit_ founder 🥑 we make food last longer with natural and residue-free tech to waste less, sell more and at a better price 🥑dhen (🌱🌾) @PadillaDhen
52 Followers 91 Following trying to do what feels right @streamclimate prev: @armSunil K. Kenchanmane .. @Sunil_KumarKR
2K Followers 1K Following Postdoc, Birnbaum lab, NYU | Incoming Assistant Professor BPSC UC Riverside | Comparative single-cell omics| First-gen| Cornhusker | Co-founder @plantpostdocsJonathan F. Wendel @JonathanFWendel
1K Followers 505 Following Plants, Evolutionary Genomics, Polyploidy, Runner, but mostly Husband, Father and Friend...Rice research : Open .. @research_rice
951 Followers 5K Following Enthusiastic publisher on research of increasing rice production and value for the poor and to help rice farmers in adapting to climate change.Artem Lomakin @LomakinAI
384 Followers 276 Following EMBL-EBI @emblebi predoctoral fellow at @MoritzGerstung group studying how cancer cells are evolving in the spatial contextFlora Jay @florajay_
552 Followers 318 Following Researcher @CNRS, LRI/LISN, Paris-Saclay France. Population genetics, stats, machine learning.simulation has been a critical tool for population genetics for some time so it's great to see two recent preprints dealing with some of its thornier issues when using forward in time models
Which tree species to plant, e.g. after large disturbances? They should do well under current climate AND be robust to future climate change. This causes a considerable bottleneck for forest management, we find in a new paper in @NatureEcoEvo. A thread… 🧵nature.com/articles/s4155…
We introduce an ARG-inspired data structure Genotype Representation Graph (GRG) to enable lossless data compression, efficient computation through graph traversal. Developed a fast inference method. Cost ~80 GBP to convert 350TB VCF (200,000 UKBiobank WGS) into 160 GB GRG.
Genotype Representation Graphs: Enabling Efficient Analysis of Biobank-Scale Data biorxiv.org/cgi/content/sh… #bioRxiv
From periphery to center stage: 50 years of advancements in innate immunity cell.com/cell/fulltext/…
New paper from the lab! Epigenetic silencing of transposons is widely considered a good resolution of host-TE conflicts, but is it? Especially, we showed that this silencing could lead to harmful local enrichment of repressive marks, even in genes (Huang et al. 2022 eLife). (1/5)
Latest in our resolution of evolutionary conflicts @RSocPublishing special feature: 'Blessing or curse: how the epigenetic resolution of host-transposable element conflicts shapes their evolutionary dynamics' Super cool from Yuheng Huang + @mobilepurin royalsocietypublishing.org/doi/full/10.10…
Exposure to air pollution linked to vehicle exhaust and fossil fuels increased risk of emergency visits and hospitalizations for mental disorders in Hefei, China. The risk declined post-COVID-19 outbreak, possibly due to staying indoors and wearing masks. cutt.ly/HwQiKGyG
scalepopgen: Bioinformatic Workflow Resources Implemented in Nextflow for Comprehensive Population Genomic Analyses buff.ly/3w0k4vb #science #evolution #biology #genome
Malnutrition is common among Rohingya women, with 26.7% of pregnant women being undernourished, likely reflecting that ~64% and 46% of non-pregnant and pregnant women, respectively, have low dietary diversity. Read more: cutt.ly/PwQQbYD8
It's impressive—I knew he was young at the time, but I didn't realize he was an undergraduate student. Next week, we will read this paper, along with a recent one, in our Genetics and Evolution graduate course.
@DalalSci my grandfather was a sophomore when Thomas Hunt Morgan took him into his lab (Fly Room @ Columbia) and as a sophomore he computed the worlds 1st genetic map! sturtevant.com/sturtevant/ahs…
🎉Thrilled to share that I will join the Dept of Botany and Plant Science @UCRiverside in fall 2024 as Asst Prof of Plant Resilience! Couldn't have done this without the sacrifices of my parents, family @drjyothi_kumar & support of mentors @KenBirnbaum @szintri @Rebecca_Roston...
A shift from pleiotropic to modular adaptation revealed by a high-resolution two-step adaptive walk biorxiv.org/cgi/content/sh… #biorxiv_evobio
Why do transposons jump at highly variable rates, and what does that mean to host evolution? In this @AnnualReviews, @texasrulz1, @kweiosis, Yuheng, and I integrated classic pop gen theories and new empirical data to explore this long-standing question. annualreviews.org/content/journa…
icddr,b Senior Scientist Dr. Rubhana Raqib provided commentary in @TheLancet on a promising Phase 1 vaccine trial for typhoid and paratyphoid, highlighting the importance of the vaccine as there is currently none approved for paratyphoid. cutt.ly/rw5lEIGI
A social safety net-based parenting and nutrition programme developed by icddr,b improved the cognitive, language, and motor development of children aged 6-16 months, a new study published in @LancetRH_SEAsia reports. Read more: cutt.ly/sw5lMdRi
cities nowadays are full of this kind of crime (skinny jeans with timbs)
Curious to know what effective population sizes looks like across the globe? Look no further! Out now in Molecular Ecology, our team assessed effective size of wild populations, comparing between taxonomic groups and in relation to the 50/500 rule. bit.ly/3TYrhEa
Two years ago, one of my friends requested that I draw a healthy plant. I therefore painted a striped tulip! hgpenningtonart.co.uk/plants/tulip
Tu amigo el psicoevo:
Sandra the Orangutan started washing her hands after observing her caretakers doing it.