ASHansen Lab @hansen_lab
We seek to understand the molecular mechanisms that regulate genome organization and gene expression in time and space. Based in @MITdeptofBE ashansenlab.com Cambridge, MA Joined August 2019-
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Jamie Drayton and I were fortunate to contribute RCMC to this beautiful paper from Eder, Moene...van Steensel that systematically maps the relationship between enhancer location and gene expression (and nice to see RCMC predict expression in Fig 2H-I): science.org/doi/10.1126/sc…
Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin. STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation. nature.com/articles/s4159…
Who's up at BATS? @VarshiniRam23 (@hansen_lab @Anders_S_Hansen): “3D Genomic Mapping Across Human Erythropoiesis” ow.ly/8NXO50WVNaB
Congratulations to Dr. Viraat Goel and Dr. Domenic Narducci, both new PhDs in Biological Engineering from the lab!
(1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers biorxiv.org/content/10.110…
(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…
(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110… https://t.co/sC88qF94cM
Check out Masahiro Nagano's preview sciencedirect.com/science/articl… of a very cool paper from Tjalsma...Wouter de Laat: cell.com/cell-genomics/…
Check out Masahiro Nagano's preview sciencedirect.com/science/articl… of a very cool paper from Tjalsma...Wouter de Laat: cell.com/cell-genomics/… https://t.co/5RcUP9Nllr
Mostly on BlåSky but excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%). We quantify mESC 36k loops: <loops> are generally rare (2.3%). biorxiv.org/content/10.110…
Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)
Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge) https://t.co/FqeFEN5nsp
Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk
Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk https://t.co/jn7inuPIAp
Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: biorxiv.org/content/10.110…
Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: biorxiv.org/content/10.110…
Come and see James' BATS talk today
Come and see James' BATS talk today
Congrats to @GavinSchlissel @Pulin_Li with single-molecule imaging contribution from @DomenicNarducci @hansen_lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pn…
Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab . Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.110… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.110…
Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab . Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.110… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.110… https://t.co/71cwEMfAyx
Bittersweet to say goodbye to Christos last week - Thanks for 2 fantastic years and all the best for grad school at Columbia!
Congrats to Ava @AvaConyer on a fantastic MSRP poster presentation on the polycomb work she did together with Sumin @suminkim28 !
Excited to welcome Jacob @Kaestelhansen as a new Novo Nordisk Foundation post-doc to the lab!
Here's our new group photo taken by @labronic_mike
Check out Sarah's new review on bidirectional promoters: sciencedirect.com/science/articl…
Check out Sarah's new review on bidirectional promoters: sciencedirect.com/science/articl…
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