#CPPPLU Highlights: A recent study from the Am J Emerg Med found no difference in improved hemostatic efficacy in patients on antiplatelet therapy who received desmopressin for hematoma expansion. #PharmICU @MeganARech @CBthePHARMD @GilbertPharmD loom.ly/2rA1slc

#CPPPLU Highlights: This study from @Crit_Care found epinephrine use in refractory shockable OHCA was negatively associated with achieving a favorable neurologic outcome and overall survival. #PharmICU loom.ly/26vuFM8

#CPPPLU Highlights: The secondary analysis of the DEFENDER trial in @Crit_Care found dapagliflozin led to increased diuresis and reduced fluid accumulation in critically ill patients with acute organ dysfunction. #PharmICU loom.ly/M_dcvPE

#CPPPLU Highlights: This recent trial from @yourICM found that ICU patients on low-dose ketamine infusions (0.1-0.3 mg/kg/hr) were at an increased risk of experiencing hallucinations within 30 days of ICU admit. #PharmICU loom.ly/8lQrbB4

#CPPPLU Highlights: This recent study from @yourICM evaluated the use of sodium bicarbonate in critically ill patients with metabolic acidosis. Overall, they found a 1.9% absolute risk reduction in mortality. #PharmICU loom.ly/FW4wqX0

#CPPPLU Highlights: This trial from J Intensive Care Med compared DEX to PHB as an adjunct to lorazepam for ETOH withdrawal syndrome treatment. PHB was linked to ↓ hospital and ICU LOS and ↓ intubation risk compared to DEX. #PharmICU loom.ly/Xq2Kl0E

#CPPPLU Highlights New therapeutic goal for ICH patients: Both lowering SBP and maintaining its stability. Aiming for both reduction + consistency could improve outcomes in intracerebral hemorrhage @NeurocritCareJ 🧠 loom.ly/HpJRs_Q #PharmICU

#CPPPLU Highlights A recent study in @CritCareExplore found that administration of 30 mL/kg of crystalloid 💧 by 2-3 hours of septic shock presentation ⬇️ mortality and ⬇️ need for mechanical ventilation compared with other time points. #PharmICU loom.ly/qXx_8cI

#CPPPLU Highlights Real world data show andexanet is associated with higher odds of excellent/good hemostasis but increased thrombotic events vs PCC published in @CritCareMed @NG_Panos #PharmICU loom.ly/b8yK2V0

#CPPPLU Highlights Early esmolol in hyperkinetic septic shock patients with persistent tachycardia was found to be safe and feasible in targeting a 10% reduction in heart rate ❤️ in a single center trial published in @ShockJournal #PharmICU loom.ly/N5i37Rw

#CPPPLU Highlights A recent RCT in @PharmacoJournal found that midodrine added to norepinephrine ⬇️ vasopressor needs in septic shock patients (mean difference 0.06; p = 0.002). 28-day mortality ⬇️ from 68% to 54%, but was not significant. #PharmICU loom.ly/5ejhz6w

#CPPPLU Highlights This recent trial in European Heart Journal: Acute Cardiovascular Care explored dexmedetomidine for sedation in AMI. They found an 11% ⬇️ in in-hospital mortality with ⬆️ ventilator-free and hospital-free days #PharmICU loom.ly/MYPP0N0