Search results for #FGFR3
@UroDocAsh @MattGalsky @tompowles1 @siadaneshmand @shilpaonc @LauraBukavinaMD @Uromigos @Albert0Briganti @GGiannarini @NazliDizman @ZeynepZengin @DrRaviSalgia @DrChoueiri @neerajaiims @BladderCancerUS Couldn't agree more. Clearly we overestimated the frequency of #FGFR3 in planning the trial!
Coinciding with #EAU24 & hopefully timely given terrific data from @MattGalsky from #CheckMate274 & @tompowles1 from #IMvigor011 - our attempt at adjuvant tx w #FGFR3 inhibitor #infigratinib. Huge international effort w co-PI @siadaneshmand & terrific SC incl @shilpaonc…
@Markuseckstein3 As always very interested in your pathological expertise @Markuseckstein3 Would be very interested in hearing more about LNUC and #FGFR3 mutations in this subtype
🧬🧬🏄♂️🧪 indeed LNUC are THE PROTOTYPE of aggressive #FGFR3 mutant urothelial cancer! ➡️85-90 % of LNUC harbor activating hotspot mutations in the FGFR3 gene. ➡️ other key mutations are rare, so seems to be an important driver. ➡️ However, not known whether these tumors respond…
Tyra Biosciences' TYRA-300, an oral #FGFR3 selective inhibitor, received Rare Pediatric Disease (RPD) Designation from the @US_FDA to treat #Achondroplasia. Learn more below 👇 ow.ly/YmkE50QxLnE
🔬Dr. Yi-Ching Lee and her team discovered a compound accelerating FGFR3 degradation, demonstrating promising potential for treating FGFR3-associated cancers and bone disorders.🩻 This study has been published in @JCI_insight sinica.edu.tw/en/News_Conten… #FGFR3 #Skeletal #Dysplasia
#GenomicProfiling is shining a light on the differences between bladder and upper tract cancers with #FGFR3 mutations. UTUC shows a higher mutation rate and distinct pathways Matthew Nicholas Young, MD, BSc @BartsHospital @ASCO #GU24 @OncoAlert @urotoday @DrChoueiri…
@MSKCancerCenter targeted exome sequencing of #MSI-H UC of 2,872 #UC cases showed #dMMR in 2.1%, median TMB 51.8 mut/Mb, enrichment in #FGFR3 muts, improved OS w/IO #GU24 @OncoAlert
The #FDA has granted approval to #erdafitinib for adult patients with locally advanced or metastatic #urothelial carcinoma (#mUC) with susceptible #FGFR3 genetic alterations. Learn more about the #approval and the #trial that led to it here: oncdata.com/news/erdafitin…
On January 19, 2024, the @US_FDA approved #erdafitinib for patients with locally advanced/metastatic urothelial carcinoma with susceptible #FGFR3 genetic alterations. Learn more: hmpgloballearningnetwork.com/site/onc/news/… #medtwitter #onctwitter #FDAapprovals
Gain-of-function mutations in Fibroblast growth factor receptor-3 (#FGFR3) cause #achondroplasia. #Infigratinib, a FGFR1-3 inhibitor, improves #skeletal growth in achondroplasia models, but detrimentally affects #craniofacial and #dentoalveolar tissues doi.org/10.1002/dvdy.6…
4/Encouraging data from phase3 #THOR trial: in patients with refractory post-PD1 #mUC with #FGFR3/2 alt resulted in ⬆️OS and PFS with ⬇️ TRAEs compared to chemotherapy. @y_loriot @NEJM @GustaveRoussy #Siefker-Radtke nejm.org/doi/full/10.10…
#FDA has fully approved #Balversa for treating advanced #bladdercancer. This targeted therapy, particularly for patients with #FGFR3 genetic alterations in urothelial #carcinoma, has shown a 36% reduction in death risk compared to #chemotherapy. healthandpharma.net/fda-johnson-ba…
[Press release] Excited to announce our collaboration with the urology group @Ompu & @YoshimiLab @NccriOfficial, exploring the influence of #FGFR3 alterations on the #TME and the effectiveness of #ICI in #BladderCancer. Out in Molecular Cancer ‼️ molecular-cancer.biomedcentral.com/articles/10.11…
【プレスリリース】 #膀胱がん において #FGFR3 異常が #腫瘍免疫微小環境 と #免疫チェックポイント阻害剤 の奏効率に与える影響について、@NccriOfficial がんRNA研究分野 @YoshimiLab と大阪医科薬科大学との共同研究の成果がMolecular Cancer誌に掲載されました‼️ molecular-cancer.biomedcentral.com/articles/10.11…
#SingelCell RNA #Sequencing advances in #BladderCancer Ouyang Y. et al. (Cancer Res, 2023) discovered that #macrophages play a key role in the "cold" TME of #FGFR3-mutated bladder cancer. The aim: #PrecisionMedicine Find the full article at DOI 10.1158/0008-5472.CAN-23-1065.
🔬New research suggests targeting FGFR3 could revolutionize Rheumatoid Arthritis treatment! 🎯 Curious? Learn more here: neurexplain.com/2023/11/20/unl… #RheumatoidArthritis #MedicalResearch #FGFR3 #neurosurgery
Outstanding work from Jacqueline H. Starrett showing #smallmolecule TYRA-300 can increase Bone Length in a preclinical model of FGFR3-Related Skeletal Dysplasia. #FGFR3 #Achondroplasia #ASHG23 The future for individuals with FGFR3 is very promising.