Expanding the ligand spaces for #E3 #ligases for the design of protein d... sciencedirect.com/science/articl…

Two days of science filled with future plans for @proxidrugs. The highlight was a morning run with so many members. Look forward to the next retreat. @IBC2 @goetheuni @RMU_EMTHERA #Science #TPD #molecularglues #ubiquitin #ligases

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Mohit @mohitasya

6 months ago

Two days of science filled with future plans for @proxidrugs. The highlight was a morning run with so many members. Look forward to the next retreat. @IBC2 @goetheuni @RMU_EMTHERA #Science #TPD #molecularglues #ubiquitin #ligases https://t.co/m8cuoRt0DB

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The global #ligases #enzyme #market is expected to grow from $2.59 billion in 2022 to $2.89 billion in 2023 at a compound annual growth rate (CAGR) of 11.3%. Read more @ topprnews.com/ligases-enzyme… #marketresearch #marketintelligence #TheBusinessResearchCompany #GlobalMarketModel

Of the 100s of ubiquitin E3 ligases, UBE2L3 partners with HECT and RBR ubiquitin #E3 #ligases (active-site cysteine transfer mechanism). So, we performed an RNAi sceen to find out which one(s) promote pro-IL-1b turnover in macrophages. TRIP12 & AREL1 were identified as hits!

📢New to #Pathology and #Oncology Research! Sun and colleagues summarize the role of HECT E3 #ubiquitin #ligases in the occurrence and progression of #gastric #cancer. Read and download the full article👇 fro.ntiers.in/POR1610931

This week at the Protein Degradation & Targeting Undruggables Congress, our team will be moderating expert panels covering the current landscape of #TPD, expanding the disease scope beyond oncology, and how specific #ligases open up novel #therapeutic opportunities.

Discovery for #Ligases that Govern #MYC Post-Translational #Stability: @kochinstitute themarkfoundation.org/portfolio/chem…

Preprint on #bioRxiv: biorxiv.org/content/10.110… #haiku #gpt3 #stablediffusion #ligases #e3

In the 8 years since the discovery that Celgene’s #IMiDs degrade oncogenic transcription factors by “gluing” them to E3 ubiquitin #ligases, over a dozen #biotechs have developed molecular glue degraders. See where this field is headed > (FREE with reg) ow.ly/X4l250Mkkoy

Harness the power of RNA and DNA Modifying Enzymes, discover how these critical tools are still helping to advance biological discovery, diagnostics and therapeutics.  Read more: ow.ly/EfAP50LpTA6 #modifyingenzymes #enzymes #ligases #iLoveMolBio

#Enzyme Preparation Market Size, Share & Growth Analysis To 2028 #Oxidoreductases ,#Transferases, #Hydrolases, #Isomerases, #Lyases, #Ligases Read More@ tinyurl.com/3neent6m @Novozymes @ABEnzymes @Genencor @KeminInd @BuckmanChem

Latest #oncology drugs target/degrade harmful #pathogenicproteins. However, new research identifies resistance mechanisms to this treatment and provides insights on overcoming them. bit.ly/3E2j4bh #cancer #cancerResearch #cancertherapy #ligases #drugresistance #proteins

Latest #oncology drugs target/degrade harmful #pathogenicproteins. However, new research identifies resistance mechanisms to this treatment and provides insights on overcoming them. bit.ly/3E2j4bh #cancer #cancerResearch #cancertherapy #ligases #drugresistance #proteins

Antibody targeting of #E3 ubiquitin #ligases for #receptor #degradation | Nature nature.com/articles/s4158…

The #ligases #enzyme market generated $367.4 million in #revenue in 2021, and it is projected to capture $631.7 million revenue in 2030, growing at a rate of 6.2% from 2021 to 2030. Get the sample pages @ bit.ly/3Qmjr3l #DNA, #RNA, #LCR, #LDR, #NGS, #RED, #RCA, #PLA

How much do you know about DNA & RNA modifying enzymes? Take our fun quiz now and share it with your colleagues. ow.ly/VsQO50KnqKl #ModifyingEnzymes #Ligases #iloveMolBio #MolecularBiology

Harness the power of RNA and DNA Modifying Enzymes, discover how these critical tools are still helping to advance biological discovery, diagnostics and therapeutics. ow.ly/HKzx50KnqjX #ModifyingEnzymes #Ligases #iloveMolBio #MolecularBiology

#Ligases: These #enzymes #catalyse the reaction of the synthesis of two molecular #substrates into one molecular compound thereby releasing energy. Check out more info @ longdom.org/enzyme-enginee…