Julio César @juliocesar_io
Co-Founder & CEO @fastfold_ai | AI agents for science, somehow I love building hard things juliocesar.io San Francisco, CA Joined July 2009-
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Is simple always better? That’s the question in protein folding right now. One thing is certain: more choices are always better. 🧵 SimpleFold joins Fastfold — no MSA, runs in <30s, scaling 100M → 3B params.
There is lots of chat these days about simple/fast folding models. Few people know that more than a year ago, @jeremyWohlwend and @meteos_97 built MiniFold, a super fast folding method that actually approaches ESMFold accuracy while being >10x faster. Unfortunately, they never…
This is the kind of vision we need more of.
This is the kind of vision we need more of.
Some form of AGI being years away got me thinking… What if we used AI to reclaim time, to think, observe, and imagine again? Output replaced insight. Curiosity became a luxury. With AI agents, we have a shot at something deeper—not just faster science, but freer minds. Just…
A new family of antibiotics discovered with graph deep learning.
A new family of antibiotics discovered with graph deep learning.
colleges prioritized making people feel perfectly safe over everything else and produced a generation afraid to fail, and thus afraid to take risk, and thus on pace to accomplish extremely little
The ratio of digital to biological compute is growing exponentially
I’m glad to hear this!
"VC has ceased to be the funder of the future, and instead has become a funder of features, widgets, irrelevances." Peter Thiel / Founders Fund
I will not let you down, no matter what it takes
When we see the truth in a person, we call it authenticity.
Today in @Nature: #AlphaTensor, an AI system for discovering novel, efficient, and exact algorithms for matrix multiplication - a building block of modern computations. AlphaTensor finds faster algorithms for many matrix sizes: dpmd.ai/dm-alpha-tensor & dpmd.ai/nature-alpha-t… 1/
Feeling like driving 8 hours straight listening to this. open.spotify.com/track/0BxE4Fqs…
Panic led to lockdowns. Lockdowns led to fiscal stimulus. Stimulus led to inflation. Inflation led to monetary tightening. Tightening leads to recession. The panic wasn’t free - and the bill is coming due.
I love to work hard, and to surround myself with people who work hard. We live in a culture where that's sometimes looked down upon. But alas, I am who I am. You be you. I'll be me. Deal with it. 😎
Your ability to speak clearly is enhanced by reading (not listening) to books and by writing and journaling in complete sentences. Texting, voice dictation and audio books are wonderful but degrade articulation. Conversely, structured writing aids structured speech.
Human connection a login away Absence of silence abundant smoke Posture correctly not to be a threat. juliocesar.io/torrents-of-eg…
I was once a small baby. Now I'm a large baby. Not much has changed.
Learnt this the hard way.
Be quiet, work hard, and stay healthy. It’s not ambition or skill that is going to set you apart but sanity.

Dr. Shelby @shelbynewsad
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William Rudenmalm🇪... @w_hgm
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@Neuro_AI @NeuroAI_Nexus
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Frevo @Frevo529619
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Susana Dooley @SDooley31484
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Vega Shah @dr_alphalyrae
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Israel Le Banquier @Izomorato1
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TatianaSF com @TatianaSFcom
16 Followers 270 Following https://t.co/It3F2OLZ5m CEO at https://t.co/C05QnxZqji, (O-1A, EB-2 NIW) | Running offline AI hackathons in SF | Join: https://t.co/yLgtLnKOEc
Kyler Thiel @ThielKyler59189
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Whiripee @Whiripee368916
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marc @marcbienaime
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Finn @finnlueth
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Kirmruid @Kirmruid4976
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Sathish Subramanian @sathishzam
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Reyhan Mir @MirReyhan
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Okeevlauw @Okeevlauw11009
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Nikil @bionikil
70 Followers 891 Following Just a guy loving the art of biomolecules https://t.co/rLc0lnTMd6
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Amaya @MadisynBar45513
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Stefan @stefanluke_
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.stuff @vintagestuff4
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Prai 🦊 Nickelfox D... @Nickelfoxdesign
57 Followers 617 Following 10+ years | 300+ projects | Crafting innovative digital experiences that transform ideas into reality. Let's build the future together!
Elsa @elsaburkholder2
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YL_yelo🐸🌞🐸 @yelo_yl
163 Followers 1K Following Web3/Brc20/Btc/Eth/Sol/🍀4Chan one life, its worth an attempt
Corey @design_proteins
794 Followers 557 Following Exploring bioengineering and protein design, inspired by evolution and biosolutions
Vladas Oleinikovas, P... @OleinikovasV
450 Followers 817 Following Computational Chemist - CADD/TPD; PhD Chemistry at UCL; BA, MSci Natural Sciences, Chemistry (Cantab). @OleinikovasV.bsky.social
DoraLucius @uJ9492yZ23LSJj
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MUSTAPHA YEKUSA @yakusamustapha
23 Followers 625 Following Social media manager for @elonmusk, CEO of Space, Tesla, and Neuralink. Exploring frontiers of technology and space. and the future. ~ * #SpaceX #Tesla #In
AI Nuggets @AI_Nuggetz
790 Followers 5K Following Addicted to https://t.co/8kPTBGJ4Fj Super AI tools. We regularly share updates about everything AI. Join our AI Newsletter at https://t.co/FIZXBabifD
Lucille @lucille_blake98
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DigiTechXpress @DigiTechXprs
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Clara @c_guffey98
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Margaret @hopper69margare
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Melvina @melvinaestep39
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Jesse Torres @jstorres
390K Followers 168K Following Husband - Dad - Author - Community Banker - https://t.co/d8wuSA7xN6 Contrib - Soccer Player - UCLA - Congressional Biz Person of Year - The Blockchain Banker ™️
Influencive @Influencive
55K Followers 43K Following Spreading positivity and helping entrepreneurs succeed.
Summer Thorpe @SummerThorpe12
147 Followers 3K Following I don’t make mistakes, I😻 just date them. My WhatsApp +1(901)591-3110
Freddy Vega @freddier
312K Followers 1K Following CEO, Cofounder: @Platzi 💚 The largest technology school in Spanish, 6M students
Merck @merckgroup
25K Followers 423 Following A leading science and technology company in life science, healthcare, electronics. Not intended for US&CA visitors. https://t.co/BMQ0MXnhuB…
Corey @design_proteins
794 Followers 557 Following Exploring bioengineering and protein design, inspired by evolution and biosolutions
Ernesto Arias-Palomo @EAriasPalomo
481 Followers 200 Following Molecular and Structural Biologist | Group Leader @CIB_CSIC Cryo-EM of Protein-DNA Interactions. Molecular machines. Also @eariaspalomo.bsky.social
Dr. Shelby @shelbynewsad
5K Followers 4K Following bio generalist, future maximalist. partner @compoundVC | writing https://t.co/5sTPXkvBCj
Pranam Chatterjee @pranamanam
4K Followers 339 Following Generating biologics to program biology! 💻🧫 Assistant Professor at @Penn | Co-Founder @GametoGen and @UbiquiTxINC | Formerly @MIT '16 '18 '20 and @harvardmed
Pierce @PierceOgdenJ
972 Followers 1K Following Co-Founder / CSO https://t.co/45GMwl1DMQ. Formerly PhD Synthetic Biology in the Church Lab. I build multiplex measurement technologies to enable protein design.
Lighthouse @lighthousehq_
6K Followers 5 Following The fastest immigration solution for the startup and technology industry 🇺🇸 We help the best get a US work visa seamlessly, so you can get back to building
Steven Wang @swangentr
30K Followers 760 Following CEO & Founder @dubinvest | fmr @apple @realismvr (acquired) | Harvard dropout | view more for disclosures
The Information @theinformation
121K Followers 704 Following The most authoritative publication covering tech that high-powered tech execs and founders read daily. TITV M-F at 1 ET: https://t.co/M0NywExhuj
Julia Bauman @JuliaBauman2
10K Followers 477 Following PhD student at @Stanford Genetics in @LarsMSteinmetz lab Explaining cool biotech to the world here and @ 60_SecondScience on TikTok
Ξrin Magennis🌻 @erinmagennis
4K Followers 1K Following DeSci ⋅ Don't trust, verify science @causalitynet ⋅ @MuseMatrix_ Research Institute ⋅ @DeSciMic Host • Farcaster @ erin
Vega Shah @dr_alphalyrae
19K Followers 4K Following AI for Life Sciences & Healthcare @NVIDIA | trained as a scientist from @JGI, @UW, @UCBerkeley | building global community @TechBi0 | views are all mine
Biopunk Labs @BiopunkLab
462 Followers 1 Following Renegade biotech community. Low-cost lab partners globally. 📆 Event calendar: https://t.co/mwqiuM2TdL
UC Berkeley @UCBerkeley
247K Followers 670 Following Official account of the University of California, Berkeley. Home of the @CalAthletics Golden Bears. 🐻 #BerkeleyNews #GoBears
Patrick Hsu @pdhsu
47K Followers 3K Following @ArcInstitute co-founder, @BerkeleyBioE professor, @ThriveCapital investor | 🇨🇦 prev @harvard @broadinstitute, Fast Grants
Jason Kelly @jrkelly
29K Followers 2K Following Co-founder and CEO at Ginkgo Bioworks ($DNA)🧬 Former Chair of US National Security Commission on Emerging Biotechnology 🇺🇸
D. Scott Phoenix @fuelfive
2K Followers 498 Following Ex founder + CEO of Vicarious AI (raised $250M, acq by Alphabet). Partner at @fiftyyears investing in AI safety, hard tech, and a human future. We should talk.
Aditya Agarwal @adityaag
48K Followers 329 Following General Partner @SouthPkCommons, Co-Founder @Bevel_Health | Ex: Early Eng @facebook, CTO @Dropbox, Board @Flipkart | Optimist, Builder, Dad
Arc Institute @arcinstitute
39K Followers 59 Following A new scientific institution for curiosity-driven biomedical science and technology.
Stephanie Zhan @stephzhan
25K Followers 2K Following GP @Sequoia, early stage AI. On superintelligence quest. 1st partner & board of @linear @middeskhq @reflection_ai @skildai. seeded: @heytavus @mach_industries
Jonathan Brebner @JPBrebner
4K Followers 848 Following -1 to 0, Partner @southpkcommons / public lands fan
plasmidsaurus @plasmidsaurus
11K Followers 10K Following Pioneers in the sequencing of whole plasmids, amplicons, whole bacterial genomes & more. 900+ dropboxes and 10 labs globally.
Finn @finnlueth
199 Followers 2K Following (ᴅʀᴜɢs, ᴘʀᴏᴛᴇɪɴs) × ᴍʟ. vibe coding biology. bioinformatics @TU_Muenchen. researcher @rostlab. prev @iGEM_Munich @saivaAI. 🇺🇸🇩🇪.
Karan Goel @krandiash
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No Priors @NoPriorsPod
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sarah guo @saranormous
120K Followers 3K Following startup investor/helper, founder @conviction. accelerating AI adoption, interested in progress. tech podcast: @nopriorspod
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1517 Fund @1517fund
19K Followers 428 Following We back dropouts, renegade students, and deep tech scientists at the earliest stages, before anybody else. Want to chat? Reach out:👇
Seth Bannon @sethbannon
34K Followers 677 Following Entrepreneur, investor. Founder of @fiftyyears. Make something civilization needs. Also: https://t.co/xhMPeOCKIN
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Olivia Moore @omooretweets
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Lucy Guo @lucy_guo
80K Followers 923 Following Building https://t.co/NaZlVKanzd | cofounder of @backendcapital @hf0residency @scale_ai | some would say i'm a part time promoter
Roy @im_roy_lee
157K Followers 2K Following ceo @cluely | kicked out of columbia, harvard, community college graduate
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5K Followers 317 Following CEO at https://t.co/7Ru3KbkVb9 | Forbes 30 under 30 | Stanford CS + AI | Competitive programmer
Alexandr Wang @alexandr_wang
334K Followers 837 Following chief ai officer @meta, founder @scale_ai. rational in the fullness of time
Hyperstition, Inc @hyperstition_x
6K Followers 1 Following A company developing technology indistinguishable from magic.
FutureHouse @FutureHouseSF
7K Followers 3 Following Philanthropically-funded moonshot building semi-autonomous AI to accelerate the pace of scientific discovery in biology.