Georgy Leonov @leonov_ge
Researcher at the Institute of Biomedical Chemistry. Interests: cell technology, neuroscience, oral microbiome Joined March 2012-
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Georgy Leonov retweeted
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The…
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The… https://t.co/GpqBYQtWtz
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Georgy Leonov retweeted
Excited to introduce our Cell Reports Medicine @CellRepMed @CellPressNews article with the features of overextended #healthy #lifespan vs common #chronological #time: The story of a record-breaking #supercentenarian in a world burdened by #aging-related diseases.…
Georgy Leonov retweeted
New online! Fusobacterium nucleatum: ecology, pathogenesis and clinical implications nature.com/articles/s4157…
Georgy Leonov retweeted
Mitochondrial health is crucial for overall health. Several nutrient and non-nutrient compounds have evidence for supporting mitochondrial function and health. Of note, regarding their effects on mitochondrial health, it is typical that most research concerning this topic is…
Georgy Leonov retweeted
Muscle-brain crosstalk as a driver of brain health in aging link.springer.com/article/10.100…
Georgy Leonov retweeted
Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s4158…
Georgy Leonov retweeted
Exercise-induced appetite suppression: An update on potential mechanisms physoc.onlinelibrary.wiley.com/doi/10.14814/p…
Georgy Leonov retweeted
#MicrobiologyMonday: Biofilm-associated molecular patterns (BAMPs) are expressed in biofilms at levels that can trigger an immune response, but not in free-floating (planktonic) bacteria. They may be key to understanding chronic infections. #IAIJournal: asm.social/2zc
Georgy Leonov retweeted
Online Now! Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease dlvr.it/TMdTpx #stemcells
Georgy Leonov retweeted
Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes @UPenn_SongMing @zhoujoeyyi nature.com/articles/s4159…
Georgy Leonov retweeted
Review @NatureRevCancer Ageing, immune fitness and cancer nature.com/articles/s4156…
Georgy Leonov retweeted
Exercise, the Gut Microbiome and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms sciencedirect.com/science/articl…
Georgy Leonov retweeted
#MicrobiologyMonday: Genomic integration of oncogenic DNA viruses can: 🧬 Disrupt normal genes. 🧬 Activate cancer-associated genes. 🧬 Increase genomic instability. Studying such integration helps inform therapeutic breakthroughs. #JVirology: asm.social/2wa
Georgy Leonov retweeted
Dual immunotherapeutic interventions with FDA-approved antibodies Tiragolumab (anti-TIGIT) & Durvalumab (anti-PD-1) potentiated primary NK cell activation and killing of medulloblastoma cells and organoids in PDX mouse models academic.oup.com/noa/article/7/… @BovenschenNiels @EditorNeuro
Georgy Leonov retweeted
Exciting preclinical studies demonstrate that the Glia-derived peptide Octadecaneuropeptide may be valuable for targeting weight and glycemic control via the hindbrain without eliciting the common treatment side effects seen with GLP-1 receptor agonists science.org/doi/10.1126/sc…
Georgy Leonov retweeted
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @NatMetabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n
Georgy Leonov retweeted
Emotions synchronize brain activity between people. This promotes social interaction & facilitates interpersonal understanding.
Georgy Leonov retweeted
Memory CD8+ T cells have differential cytotoxic capacities across human tissues @SciImmunology @marcus_buggert science.org/doi/10.1126/sc…
Georgy Leonov retweeted
A common virus once thought harmless to humans might be linked to Parkinson's disease, a new study says. The germ, Human Pegivirus (HPgV), was found in half the autopsied brains of patients with Parkinson's, but not in any brains from healthy people. 1/
Georgy Leonov retweeted
Neurons are for sure the fireworks in the brain! But these are lighting up because they are dying...by accumulating pathological tau, one of the neurodegenerative hallmarks in Alzheimer's and other dementias. Markers: pS 422 tau🔴AT8🟡NeuN🔵 #4thofJuly #FluorescenceFriday 🌠🔬
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