Xiuning Le MD PhD @LeXiuning
Associate Professor Thoracic Head and Neck Medical Oncology MD Anderson Cancer Center faculty.mdanderson.org/profiles/xiuni… Houston, TX Joined March 2020-
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📖 🔥 New online #firmonertinib in EGFR #PACC-mut NSCLC. @Cancer_Cell 👉 Firmonertinib has a trifluoroethoxy group, which enhances its potency against EGFR PACC mutation 👉 68% response rate with firmonertinib 240 mg daily. Median progression-free survival of 16.0 months at 240 mg. 👉 47% intracranial response rate among patients with baseline brain metastases. @EGFRResisters @Exon20Group @lungoncdoc @riess_md
Results from the Phase 1b FURTHER trial found a targeted therapy that achieved achieved durable antitumor activity for patients with EGFR PACC-mutated non-small cell lung cancer. @LeXiuning #EndCancer spr.ly/6014BHMzuy
😜 Are we ready for the era of #PD1×VEGF #bispecific immunotherapy? 📖 Now online in #LancetOncology: #HARMONi — #ivonescimab plus chemotherapy in patients with #EGFR-mutant #NSCLC after progression on EGFR TKI therapy. 👉 First global randomized phase 3 study of a PD1×VEGF bispecific antibody N = 438, with 23% of patients enrolled in the United States 👉 Progression-free survival: 6.8 vs 4.4 months, HR 0.52 👉 Overall survival: 16.8 vs 14.0 months, HR 0.79 👉 Encouraging evidence of protection against CNS progression 💡 HARMONi represents an important step in evaluating the potential of simultaneously targeting PD-(L1)1 and VEGF. I hope this will be the first of many positive global studies exploring PD-(L)1 × VEGF approaches for patients with lung cancer and other solid tumors. lnkd.in/gUbwUxTb ❤️ my global col-investigators, @Tony_Calles @delvysra @MNagasaka @DrSanjayPopat @nicogirardcurie, Drs. Passaro, Cappuzzo, Zhang, and many others ❤️
📖 Now online @CD_AACR 🔥 👉 The oncogenic #EGFR–SHC1 #fusion drives hashtag#lungcancer through dual activation of the N-terminal EGFR kinase domain and C-terminal SHC1 phosphorylation sites. This biology requires combined inhibition of both EGFR and SRC-family kinases to achieve effective clinical control. 👉 Most importantly, this represents a novel fusion activation mechanism: SHC1 acts not merely as a facilitating #fusion partner, but as a true #collaborating partner in oncogenesis: a previously unrecognized mechanism with direct therapeutic implications. 👉 Could similar cooperative signaling by fusion partners help explain de novo or early resistance in other fusion-driven cancers? 😜 doi.org/10.1158/2159-8… @ElizSMcKenna and Jurgen Wolf (University Hospital Cologne, Germany)
This is the amazing fifth @DAVAOnc Lung Summit meeting. 60% new faculties, topics were spanning from novel mechanistic discoveries to lastest FDA decsions, in all areas of #HNSCC and #NSCLC. @LaurenByersMD @fred_hirsch @maraantonoff @DasMillie11
📖 🔥New online from our group at @UTMDAnderson on ultra-precision oncology in #lungcancer 👉 Analysis from over 22,000 #EGFR-mutant tumor samples identified #PACC mutations in 12% of cases (A) 👉 While classical and #Ex20 mutations more commonly occur as single mutations, PACC mutations are more frequently (66%) observed as compound mutations (B). 👉 PACC/PACC and PACC/classical-like compound mutations function biologically similar to single PACC mutations, NOT classical mutations (C) 👉 Compound PACC mutations demonstrate greater sensitivity to EGFR TKIs than single PACC mutations (D) ⚡ 💡 Largest #EGFR mutation landscape in a Western population. ⚡ 💡 #Compound EGFR PACC Eare biologically analogous to #single PACC. ⚡ 💡 Important insights for drug development of next-generation EGFR TKIs.
🎀 💗Strong team work! BH-30643 represents a next-generation #EGFR #TKI that is potentially 10x more potent than osimertinib, strong CNS penetrance, and able to overcome on-target EGFR resistance! @Exon20Group @EGFRResisters @UTMDAnderson @mollylisc @geoff_oxnard @jjeancui
🆙 #ASCO26 #LCSM Rapid Oral 🔥SOLARA: BH-30643 (Macrocyclic OMNI-EGFR TKI) in EGFRm ✅C797S+ ORR 59% ✅C797S VAF >99%📉in 7/9 ctDNA+ pts ✅G3 AEs 18% (mainly T-bil) 🎙️ @LeXiuning @HHorinouchi 🔢3014 ☑️NCT06706076 🔗 asco.org/abstracts-pres… @OncoAlert @Larvol @ASCO @IASLC
Kicking off #ASCO26 by celebrating the Giants of Cancer Care induction ceremony! 🎀Congratulations to Dr. Wakelee @HwakeleeMD for Thoracic Malignancy 🎀Congratulations to Dr. Kopetz @skopetz for GI Maligancy @UTMDAnderson 🎀Congratulations to Dr. William Wierda for Leukemia 💐💐💐With friends @drgandara @JoelNealMD @riess_md
At #ASCO26, the @UTMDAnderson Thoracic Medical Oncology Department will deliver an incredible 9 oral presentations💐💐💐 highlighting advances across ##EGFR, #HER2, #KRAS, #KEAP1/STK11, #SCLC, IO, #peri-operative, all lung cancer subgroups. For perspective, thoracic medical oncologists from China have 16 oral presentations. 👩⚕️🧑⚕️ 👩🔬🧑🔬Our entire MDA Thoracic team @FSkoulidis @NIVokes @LaurenByersMD @lungoncdoc Drs. Heymach, Cascone, Zhang, @mvnegrao @YYElamin @AnneTsao2 are deeply proud and excited 😀to help shape the future of lung cancer research and patient care alongside outstanding collaborators and industry partners.
Dr. Stephen Liu @StephenVLiu gave the insightful vision on how #AI will impact our clinic, including patient care, physician wellness, clinical research and drug development. @StephenVLiu at #RomeLung26 Thank you @FedericoCappuz1 @BRicciutiMD for organizing this fantastic #lung #summit
Exciting program with impressive global faculty at #RomeLung26 with chairs @FedericoCappuz1 and @BRicciutiMD starting the meeting!
Strongly support my @UTMDAnderson colleague Dr. Hussein Tawbi @HTawbi_MD for #SITC Director election ❤️💐 👉Hussein is an internally renowned #physicianscientist immune-oncology leader who has helped redefine what immunotherapy can achieve in some of the most challenging clinical settings. 👉His leadership of the CheckMate 204 study established the role of nivolumab + ipilimumab in melanoma brain metastases, a historically underserved population, 👉He led RELATIVITY-047 which enabled the approval of nivolumab + relatlimab, introducing LAG-3 as a new checkpoint target. His voice and compassion, grounded in patient care and scientific rigor, would be an outstanding addition to the #SITC Board as we navigate the next era of immunotherapy innovation. 🚀
The #SITC election starts on Friday! The three At-Large Directors who receive the plurality of votes will begin three-year terms in 2027. Read the biographies and platform statements of this year’s candidates at sitcancer.org/get-involved/2…
Strongly support Dr. Zhen Su @MyOncology , my friend, colleague, and mentor for SITC Director election. 💪❤️ 👉When he served as the global oncology leader at #MerckKGaA/#EMDSerono, he translated complex immune biology to approvals, then becaome impactful therapies for patients. He has multiple global approvals across agents such as #avelumab, #tepotinib, #erbitux and others. 👉Now as the CEO of #Marengo, he is a true architect with vision, taking first-in-class T-cell agonist programs from platform stage into human studies and secured strong partnerships. 👉Zhen has been a long-standing contributor to the #immuno-oncology community, including leadership roles within #SITC. His vision of bringing early discovery to global commercialization will continue shaping the development of next generation immunotherapies. 🚀
The #SITC election starts on Friday! The three At-Large Directors who receive the plurality of votes will begin three-year terms in 2027. Read the biographies and platform statements of this year’s candidates at sitcancer.org/get-involved/2…
Appreciate @StephenVLiu and @CharuAggarwalMD organizing a fantastic US Focus Meeting Lung Cancer. I discussed 1L EGFR-mut NSCLC landscape evolution with friends and colleagues @riess_md @JuliaRotow @JustinGainor @ShirishGadgeel @BalazsHalmosMD. Nashville is a charming city with such fun characters.
Inaugural US Focus Meeting on Lung Cancer from @_MDEducation starts in Nashville with EGFR session. Great overviews by Drs. @LeXiuning Liza Villaruz @ZPiotrowskaMDand panel chaired by @CharuAggarwalMD. Great areas for discussion including LCT, bispecifics, and ADCs.
@StephenVLiu But super productive?!
😊 🩷 Nice to see friends and colleagues in the #lungcancer community from different continents at #ELCC26. @caliraf @Alfdoc2 @HHorinouchi @MartinReck2 @Tony_Calles @DoctorJSpicer @fred_hirsch @bensolomon1 @NReguart @BalazsHalmosMD @BrendonStilesMD @mollylisc @karenkellymd @ThomasW35874311 @NadalErnest @DrSanjayPopat 😊 🩷 Safe travels ✈️ 💐💐💐Grateful for the wonderful organization between @IASLC and @esmo for an impactful and fun #ELCC26.
We discussed innovations in ADCs to overcome topo-payload ADC resistance. 🔥Novel payloads include dual-cytotoxic, radioligands, immune stimulators or engagers, oligonucleotides (siRNA), degraders, and small molecule inhibitors. 🤣 Yes, "Any-Drug-Conjugates (ADC)" ❤️💡
💥 Beyond traditional ADCs at #ELCC26! @LeXiuning ▪️Masked ADCs → tumor-activated targeting ▪️Nanobodies & peptides: better penetration, new epitopes ▪️Bicycle toxin conjugates: ultra-small, fast delivery 🎯 Innovation across 3 axes: target, linker, payload From ADCs to
Honored to be delivering two educational lectures at 🔜 #ELCC26 @myESMO🇩🇰 in Copenhagen. 📍 March 26. 👉Beyond traditional ADCs: Advances in targeting, conjugation, payload design, and emerging modalities 📍 March 28 👉Mechanisms of resistance: Lessons from EGFR-mutant and ALK-rearranged NSCLC 💐Grateful to the conference chairs @DrSanjayPopat @APassaroMD for your excellent work on organizing #ELCC26. 💗Looking forward to great discussions and connecting with global colleagues @HHorinouchi @ThomasW35874311 @Alfdoc2 @caliraf @tnewsomdavis @YYElamin @lungoncdoc
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whimsical Bai @eiraterra
147 Followers 930 Following 自由让我胡作非为！胡说八道！胡言乱语！胡作非为！胡搅蛮缠！为非作歹！无法无天！任性妄为！信口开河！满口胡诌！ ⛔️对我的不当言行绝不反思！不自省！不内耗！不客观！不道歉！ 🔇还未成年！禁止说教！评判！教育！指点！较真！杠精！曲解！骂我！怼我！拆穿！指责！阴阳！蛐蛐我！我玻璃心，我会诅咒你拉不出屎！
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2K Followers 837 Following GI Medical Oncologist, @UTMDAnderson: unknown primary, colorectal, and pancreatic cancer + high-quality cancer care delivery. Tweets mine.
Urs Weber MD @UrsWeberMD
722 Followers 330 Following Thoracic Oncologist 🫁 at @CUCancerCenter. Views are my own.
Edgardo Santos, MD, F... @EddieSantosMD
334 Followers 152 Following Medical Director-Broward, Florida; The Oncology Institute of Hope & Innovation; Thoracic Oncology; Clinical Associate Professor, Florida Atlantic University
Sarah Waliany, MD, MS @SWaliany
1K Followers 905 Following Thoracic Medical Oncologist @MassGenBrigham @MGHThoracicOnc @HarvardMed | #TargetedTherapies #ADCs #EarlyDrugDevelopment #LungCancer
Tom Powles @tompowles1
14K Followers 88 Following Interested in Urology Cancers, biomarkers and drug development.
Tony Zhuang @tonygazibo
407 Followers 499 Following Heme/Onc Fellow @MDAndersonNews via @EmoryMedicine, @UTHSCMedicine & @RiceUniversity. Nature enthusiast & lifelong learner
Paul Stockhammer @StockhammerPaul
523 Followers 448 Following Heme-Onc Fellow at @YaleCancer. Interested in #HER2 and #EGFR driven lung cancer. #LCSM
U.S. FDA @FDA
592K Followers 81 Following Our posts are FDA Approved! Privacy Policy - https://t.co/LbTJXYRXVP FDA Authentic Accounts - https://t.co/w2LNbzG7M0
Oncology News @Oncologynewspro
241 Followers 1K Following Focusing on the cutting-edge information of tumor diagnosis and treatment.
GLCC @globalungcancer
2K Followers 1K Following The GLCC is the international 'voice' of people with lung cancer. Established in 2001, we now comprise 44 non-government patient organisations world-wide.
Oriol Mirallas MD @DrMirallas
2K Followers 1K Following Fellow @UTMDAnderson | Trained @VHIO @vallhebron 📚 Prep the Steps-USMLE❓👇🏽 https://t.co/Lh6juX5GmC Vocal @COMBarcelona Prof @SalutUIC @OncAlert 👏🏽
Dr Riyaz Shah @DrRiyazShah
4K Followers 630 Following Consultant Thoracic Medical Oncologist, UK. Views are hypothesis generating discourse.
Annals of Oncology @Annals_Oncology
52K Followers 554 Following Medical oncology journal with a specific interest on targeted agents, immune therapies, personalised medicine, molecular pathology, bioinformatics, and more.
Meimei Zheng @Nicmmzh126
175 Followers 562 Following Medical oncologist, Guangdong Lung Cancer Institute, Guangzhou, China
Carol Wu @carolcwu1
670 Followers 445 Following Professor of Radiology at MD Anderson Cancer Center. Thoracic radiologist. Tweets are my own.
Nirmal Raut @oncologician
7K Followers 6K Following Masters of molecular oncology (CNIO ) Medical Oncologist by profession (Lung is close to my heart), researcher by passion, precision oncology,liquid biopsy.
Byoung Chul Cho, M.D.... @cbcbc1971
100 Followers 3 Following Professor, Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine
Giuseppe Banna @gbanna74
2K Followers 1K Following Consultant Medical Oncologist for Lung and Urology Cancer aiming to Clinician Scientist #lungcancer #urologycancer. I love my work but my family is my life
CA: A Cancer Journal ... @CACancerJournal
11K Followers 2K Following As the flagship journal of the American Cancer Society, CA publishes the latest cancer statistics, ACS guidelines, and reviews on the current state of cancer.
Raffaele Califano @caliraf
1K Followers 487 Following Thoracic Oncologist @TheChristieNHS, Honorary Professor @UoM_DCS . Member @myesmo Educational Publication WG. Views are my own No DMs or medical advice given.
TerriConneran @TerriConneran
1K Followers 878 Following T like Trouble @KRASKickers Too spunky for #LungCancer Kicking cancer’s #KRAS #research #advocate #survivor #hope ❤️🤣🙏#biomarker NO #KRASholes
Baby K💕 @vinaykjain17
163 Followers 272 Following Dm for meets|Facetime|custom vids available|HMU for enquiries| must be deposit ready⬇️|MDNI 🔞
DAVA Oncology @DAVAOnc
2K Followers 2K Following DAVA Oncology is a strategic consulting company committed to delivering high quality oncology education and expanding access novel cancer therapies.
ONCO BRUNO @brunolarvol
7K Followers 7K Following @LARVOL | 100 experts building onco super intelligence | 200,000 KM curves digitized | free for non-commercial use | ex-IBM
Federica Pecci @pecci_federica1
486 Followers 557 Following Research Fellow at @DanaFarber Thoracic Oncology
jamei_zhang @jaemi_zhang
1K Followers 326 Following Chinese entrepreneur living in the US. I run my own business and enjoy traveling and fishing. Let’s connect and share good vibes together.
Misty Dawn Shields @drshieldsmd
2K Followers 2K Following Translational Thoracic Oncologist #MDPhD, #SCLC, @TheShieldsLab, Indiana University, HHMI Med Into Grad Scholar/IASLC ILCF/ASCO CDA, founder @SCLCSMASHERS 🫁🤍
OncoAlert @OncoAlert
43K Followers 138 Following 🌐 Worldwide oncology professionals network | Run by oncologists, for colleagues | All tumor types | Non-profit 🚨 We are #OncoAlert | Oncology360°You might like
