Lum Lab @lum_lab
Julian Lum's Lab - Autophagy, cancer & immunometabolism. "If you don't fail, you aren't taking enough risks". Views are our own. Tweets by Julian-JJL LumLab.ca Victoria, British Columbia Joined February 2019-
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Now online in @CD_AACR: Activation of T Cell-Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy - by Xiaojun Yan, Wei Gu, Donglai Wang, et al. doi.org/10.1158/2159-8… @columbiacancer #ChineseAcademyofMedicalSciences #PekingUnionMedicalCollege
Clearing the hurdles for CAR-T cell treatment bit.ly/4nMJ9z9
Highlighting some of the many current pitfalls of A.I. in health care @NewYorker @DhruvKhullar newyorker.com/magazine/2025/…
We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here: biorxiv.org/content/10.110…
Sucralose consumption ablates cancer immunotherapy response through microbiome disruption @CD_AACR aacrjournals.org/cancerdiscover…
Review @NatRevClinOncol 🇩🇪 Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities nature.com/articles/s4157…
Despite the benefits of a Ketogenic Diet in reducing body weight, over long time, it can lead to dyslipidemia, fatty liver, and glucose intolerance in mice. science.org/doi/epdf/10.11…
#Throwback COMMENT | J Van den Bossche et al. A call for accessible tools to unlock single-cell immunometabolism research nature.com/articles/s4225…
In our new review @trendscancer, we summarize all things CAR T cell persistence, including clinical data, multi-omics on patient CAR T, advances in CAR T engineering, and more! Amazing effort led by @kpmueller1 and @JGrenierMDPhD! Tweetorial 👇🏻 Link: authors.elsevier.com/a/1lo798Z12ybX…
In our new review @trendscancer, we summarize all things CAR T cell persistence, including clinical data, multi-omics on patient CAR T, advances in CAR T engineering, and more! Amazing effort led by @kpmueller1 and @JGrenierMDPhD! Tweetorial 👇🏻 Link: authors.elsevier.com/a/1lo798Z12ybX…
RESEARCH | AD Rao, L Cai, RJ DeBerardinis, @JenniferGillMD et al (@UTSWMedCenter) A detailed metabolic comparison between primary #tumours from #patients and their matching #xenografts, which identifies conserved as well as divergent #MetabolicPatterns nature.com/articles/s4225…
Check this out!!!
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer go.nature.com/4gprwme
Tracking dietary exposures with metabolite biomarkers go.nature.com/3K4QFXw
RESEARCH | SV John, J Fan et al (@UWMadison) John et al. show that upon classical activation, #macrophages undergo #Nitricoxide driven reprogramming of #nucleotide metabolism, which affects immune functions and responses nature.com/articles/s4225…
A paper in @Nature presents a new artificial intelligence model that can predict how a person’s health might change over their lifetime. This tool could help doctors and health planners to better understand and prepare for personalized medical needs. go.nature.com/4mFzPfz
Congratulations to Dan Pham for her paper published today! Dan showed that autofluorescence lifetime imaging can monitor single cell metabolism to improve CAR T cell metabolic fitness. @sahakris @UWCarbone @Morgridge_Inst @UWMadEngr rdcu.be/eGExD nature.com/articles/s4155…
Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis go.nature.com/3K3CdPx
For readers interested in cancer therapies, this review discusses how metabolic dysfunction of CD8 T cells and NK cells can diminish their anticancer activity, and assesses therapeutic strategies to overcome this nature.com/articles/s4157… rdcu.be/eFqm2
Engineering myeloid cells for cancer immunotherapy dlvr.it/TMz3Sc
#ScienceSaturday ❓ Why do some cancers resist anti-PD-1 immunotherapy? ➡️ A new study in @Nature shows that cancer-induced nerve injury (CINI) drives resistance. Tumors that damage nearby nerves trigger chronic inflammation, creating an immune-suppressive environment that…

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