Marie Robert @mimrobert
PhD student @InstitutPasteur @criu1149 | Resident in Internal Medicine and Clinical Immunology @APHP Paris, France Joined May 2022-
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Maladaptive trained immunity in viral infections In this Review, Dmitri Sviridov et al. @GWtweets posit maladaptive trained immunity arises from contextual factors and discuss its contribution to system disease and viral vaccine responses. jci.org/articles/view/…
A 79 y/o man with an 8-month history of VEXAS, with myelodysplastic syndrome, presented with acute-onset fever, bilateral anterior nodular scleritis, and a pustular skin rash. Exam showed large, widespread, non-follicular pustules Clinical images in A&R doi.org/10.1002/art.43……
Anti-ADAMTS13 antibodies trajectory is associated with ADAMTS13 recovery in immune-mediated #TTP doi.org/10.1002/ajh.70… #hematology
Thrilled to share our latest RCT in #EGPA comparing Rituximab Versus Conventional Therapy for Remission Induction, and published in @AnnalsofIM - Thanks to all the amazing French Vasculitis Study Group 🙏🙏🙏 acpjournals.org/doi/10.7326/AN…
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome Congrats @PBreillat @TerrierBen @KosmiderO ashpublications.org/blood/article-…
ICYMI: Chemotaxis as a driver in immune privilege. O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege. jci.org/articles/view/…
Our paper with @ArthurMageau is out in @AjHematology 🗞️ Close monitoring of anti-ADAMTS13 antibodies titer may guide immunomodulation strategies #iTTP 🩸 Thanks to the wonderful team of CNR MAT 🤝🏼 🇫🇷 onlinelibrary.wiley.com/doi/10.1002/aj…
🔍 New study: Cluster analysis identifies 3 distinct clinical patterns among patients with systemic autoimmune diseases & anti-Ku antibodies 🫀 Cardiac involvement is common & evolves differently across clusters—highlighting need for vigilant follow-up 👉rmdopen.bmj.com/content/11/2/e…
NEW RESEARCH for #LUPUS2025—Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study bit.ly/43lRzol Plus, linked Comment bit.ly/3STJLoV
Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet, @AhmadYatim_ et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. hubs.la/Q03hcY8_0
#NewNProt: Protocol Extension describing joint spatially resolved epigenomic and transcriptomic profiling on a tissue section using #microfluidic chips bit.ly/4hLs7xT #spatialtranscriptomics #spatialepigenomics see also associated News&Views
Five years after the first description by our group and others of SOCS1 insufficiency as a new cause of monogenic immune dysregulatory disorder, we are very pleased to share this international cohort of patients just published in @TheLancetRheum thelancet.com/journals/lanrh…
Trained immunity in chronic inflammatory diseases and cancer bit.ly/4jCG2IK
.@Clemence_Dvd et al. @crow_lab suggest that UNC93B1 mutations cause monogenic systemic #lupus erythematosus or chilblain lupus due to differentially enhanced TLR7 and TLR8 signaling. hubs.la/Q033w5Y-0 📘 In our #Immunology update collection: hubs.la/Q033vWth0
See our Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis 🇸🇪🇫🇷 thanks to Etienne Villain @NaderYatim @ArthurMageau @RaphaelBorie @nathanpsmad @darragh_duffy and all co-authors publications.ersnet.org/content/erj/65…
Nonischemic cardiac involvement in VEXAS syndrome is rare, primarily pericarditis, myocarditis, and heart vasculopathy; these are directly linked with VEXAS’s systemic inflammation. ja.ma/3VBtNBJ @mimrobert @TerrierBen @mekinian2 @RimBourguiba1 @SophieGeorgin
💙🤍♥️
Trained immunity in the bone marrow: Hub of autoimmunity dlvr.it/TG4mqW
Merci à la Villa M, au groupe Pasteur Mutualité et leurs mutuelles partenaires de soutenir notre projet MoSAR !! Merci aussi à l’@institutpasteur et à l’@APHP de rendre ce projet possible !! @darragh_duffy @NaderYatim @KarimSacre @nathanpsmad @RaphaelBorie on avance !!

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The Lancet Haematolog... @TheLancetHaem
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