Dr. Mandar V. Deshmukh @mvdeshmukh
Dr Mandar V Deshmukh, SrPr. Scientist (Biomolecular NMR, RNA Biology, Protein:RNA Structures) @ CSIR - Centre for Cellular and Molecular Biology, Hyderabad, IN e-portal.ccmb.res.in/e-space/mandar… Hyderabad, India Joined January 2010-
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Are you interested in analyzing protein dynamics by NMR? Check out the recent paper. Congratulations to @ApurvaPhale @kschakrabarti, and the other authors! rdcu.be/eG2TH
This study not only reveals how middle segment of SPIN90 is important for its dimerization, but how a dimeric SPIN90 is critical for activating Arp2/3 complex for nucleating linear filaments. Each SPIN90 makes unique contacts with different Arp2/3 complex subunits.
Besides unidirectional filament nucleation by a single Arp2/3 complex we also resolved bidirectional filaments nucleated by two Arp2/3 complexes activated by a SPIN90 dimer.
When a cell has to change its shape, it needs to alter its internal skeleton made of actin. And, it does so within microseconds. @saikatLab show actin filaments can grow in two directions and how. Thus, offering rapid changes in cell shapes. In @NatureSMB: nature.com/articles/s4159…
Excited to share @saikatLab's 1st paper from @ccmb_csir, #cryoEM structures on how SPIN90 dimer activates Arp2/3 complex to nucleate linear #actin filaments. Congrats to @JustusFrancis4 @Achyuthkrishnap @tejashyam_k @SridharKul34677 @RishavMitra9 @Kiranvyshnav99, Heidy & Brad
Excited to share @saikatLab's 1st paper from @ccmb_csir, #cryoEM structures on how SPIN90 dimer activates Arp2/3 complex to nucleate linear #actin filaments. Congrats to @JustusFrancis4 @Achyuthkrishnap @tejashyam_k @SridharKul34677 @RishavMitra9 @Kiranvyshnav99, Heidy & Brad
📢 We’re hiring! @StanfordUChem is now accepting applications for a Junior Faculty Position in Chemistry (open area), with the appointment set to begin on September 1, 2026. Learn more and apply here: facultypositions.stanford.edu/cw/en-us/job/4… #FacultyJobs #AcademicJobs #Hiring
Our review on ion NMR for biomolecular systems: sciencedirect.com/science/articl…
GV Rx : A10 kg dumbbell might look miniscule and featherly to lift, but 10 kg on your body is humongous to carry . Choice is yours. #TransformationGoals #HealthMatters #WeightLossJourney #BodyTransformation #HealthGoals #SmallStepsBigImpact #FitnessMotivation #BodyGoals
The complexities and entire gamut of functions of proteins cannot be captured in their static images. Studies from @DrSankarCCMB and @mvdeshmukh highlight the importance of detailed understanding of protein composition and dynamics.
The complexities and entire gamut of functions of proteins cannot be captured in their static images. Studies from @DrSankarCCMB and @mvdeshmukh highlight the importance of detailed understanding of protein composition and dynamics.
Publication alert! Krishnan, I & Sanjay DNA to RNA Tuning of a Pyrrolidine-Derived Quinoxaline Scaffold: Magnesium Induces Binding and Inhibition of Internal Ribosomal Entry Site RNA-Mediated Translational of HCV | ACS Pharmacology & Translational Science pubs.acs.org/doi/full/10.10…
100 years have gone by, and we still donot know what it really means.
There's been amazing progress against liver cancer over the last 60 years (Specifically, hepatocellular carcinoma treated with surgery) What's driven the progress? Earlier detection, safer and better operations, better biomarkers, and better treatment of recurrence
on behalf of Pro James Keeler (University of Cambridge) considering the possibility of revising the text and creating a third edition : Understanding NMR Spectroscopy, James Keeler - survey concerning a possible third edition cambridge.eu.qualtrics.com/jfe/form/SV_77… #NMRbooks #NMRchat #NMR 🧲
If you have ever wondered why many DNA/RNA-binding proteins have negatively charged IDRs, this review may be helpful. pubs.acs.org/doi/10.1021/ac…
#ResearchExplained! In a first, @VivekHariSunda1 & team from Dr @shivaprasad_pv's group at NCBS has identified a new H4 histone variant in rice which may have helped semi-aquatic rice varieties adapt to changing environments.🌾 Read here:bit.ly/4jNcirp By @Rupsykhurana
Introducing in-cyclo NMR, a new method led by @GuillaumeMas2 at @biozentrum (@NatureComms)! This method combines high-resolution NMR with ATP regeneration & phosphate removal to resolve kinetics & dynamics of molecular machines - all in one experiment! doi.org/10.1038/s41467…
"We fail much more than we ever succeed. We know that. We accept that. We're amazing at dealing with failure. That's what scientists do." 2021 chemistry laureate David MacMillan on what failure means to him. What does failure mean to you?
Rare but Real: Portal Annular Pancreas (PAP) poses unique surgical challenges during Whipples - AIG Hospitals' Department of Surgical Gastroenterology Click doi.org/10.14701/ahbps… to read the full article. #WhippleProcedure #AIGHospitals #GISurgery #Pancreatoduodenectomy

Dhanuush (he/him/his) @dhanuush_
827 Followers 1K Following Interested in Biology, SciComm (@preLights), and Traveling. Project Student @CCMB_CSIR Prev : @IISERMohali'25 @LundUniversity @MPI_HLR @IITKanpur 🏳️🌈
Apurva Phale @ApurvaPhale
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Jose Luis Balcazar @balcjos
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Debmalya Chattopadhya... @Neelchatto99
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Proofig AI @Proofig
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Steffi @rajusteffi1
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Shubhendu Palei @spalei
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Sriram Kanvah (శ్... @sriram_kanvah
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Smarajit Polley @PolleySmarajit
274 Followers 507 Following Protein Kinase, CryoEM, Directed Evolution...let’s have fun in and around science...😊..love photography…📸!..views personal
Tatini Rakshit Lab �... @RakshitTatini
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Guillaume Mas @GuillaumeMas2
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Ashraf Saad, bridging... @AsAshraf123321
2K Followers 5K Following ⚠️Research in fantasy until fantasy becomes a reality⏳️ 🚨Believe in complement-dependent cytotoxicity thru #Lectins as the future of immunotherapy‼️ #GlycoTime
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NatureStructMolBiol @NatureSMB
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Rakesh Mondal🇮🇳... @RakeshMondal22
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