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Great to visit Baylor University today for a seminar ! Special thanks to @RomoGrp_Baylor @JohnWoodGroup for hosting me and for the great chemistry and conversations!
Congratulations on this excellent work Stan ! We also thank our collaborators at BU, McGill, OHSU, and @PelagoBio for their contributions !
Congratulations on this excellent work Stan ! We also thank our collaborators at BU, McGill, OHSU, and @PelagoBio for their contributions !
Congratulations to Holly McAnlis, Hanna Warinner, and Angel Borge for passing their 2nd year qualifying exams ! I am very proud of all of you and the excellent chemistry that you are developing!
We are excited to have our MIRA grant funded by NIH! This generous support will enable our group to advance our work related to the eradication of bacterial biofilms and develop synthetic approaches to rapidly access new scaffolds from indole alkaloids to explore disease biology!
today we had a chance to celebrate Dr. Feng Yang, who will be leaving us soon for a position at Boehringer Ingelheim. Congratulations Feng on your excellent work!
On Friday, we officially welcomed the Derosa lab with a margarita party ! Exciting times at BU in organic synthesis !
Great seminar and visit Joel !
Congratulations to Kaijie Ji and our collaborators James Mcneely (BU) and Prof. Richard Johnson and Md Al Faruk from UNH on their exciting paper which reports rapid syntheses of nidulalin A / nidulaxanthone A and computations to probe reaction mechanisms. pubs.acs.org/articlesonrequ…
Interested in building a diverse skillset as part of your synthetic organic PhD? Apply to our Chemistry Graduate Program @BUChemistry before Dec. 15! Join our team @derosalab to tackle synthetic organic challenges with catalysis and electrochemistry! #chemtwitter #phdchat
Interested in building a diverse skillset as part of your synthetic organic PhD? Apply to our Chemistry Graduate Program @BUChemistry before Dec. 15! Join our team @derosalab to tackle synthetic organic challenges with catalysis and electrochemistry! #chemtwitter #phdchat
Exciting Joe- congratulations to you and everyone on the Derosa team. We look forward to great chemistry in 2024!
Exciting Joe- congratulations to you and everyone on the Derosa team. We look forward to great chemistry in 2024!
I am looking for a postdoctoral researcher (to start immediately) to work on ultrafast spectroscopy of polaritonic systems. Experience in nanofabrication preferred but not required. Please visit my website to apply: msonlab.com #chempostdoc
Nice work Allie (and Josh)!
Season’s greetings from the Porco group ! We had a great 2023 wrapup which featured a Secret Santa gift exchange.
A very warm welcome to Wenzhen Deng and Ryan Baker to the Porco group as G1 students. We are excited to have you in the lab and we look forward to great chemistry !
Congratulations Corinna and Corey - great job !
Congratulations Corinna and Corey - great job !
Great lecture Song !
Great lecture Song !
absolutely, Joe. Exciting times at BU Chemistry!
absolutely, Joe. Exciting times at BU Chemistry!
Well thank you Damian - you are a hero of mine as well !
Well thank you Damian - you are a hero of mine as well !
Congrats Joe !
Thanks Rob - great to meet with you and a great day at UF !
Thanks Rob - great to meet with you and a great day at UF !
J. Am. Chem. Soc. @J_A_C_S
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199 Followers 176 Following News from the Wright Group at Baylor. Departments of Biology and Chem & Biochem. ChemBio and Microbiome research. Schofield Endowed Chair in Biomedical Science
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Redred🇲🇽 @MilesRed2
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Davide BT @BtDavide
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Miura Lab @tmiura_chem
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Paul Lee (plee2061.bs.. @plee2061
258 Followers 577 Following Liverpool FC, Ireland & Scotland rugby fan | casual D&D nerd | grad student @ Boston College Chem | fan of any day that has a full fry-up, a pint & a long hike
suman das @sumanda82902860
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Wen Wang @wen_2459922518
128 Followers 2K Following natural products, biosynthetic enzyme, biocatalysis, postdoc@Seebeck group in Univ. of Basel, PhD@Institute of Functional Biomolecule in Univ. of Nanjing
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68 Followers 838 Following
ming shang @SJTU @mingshang09
186 Followers 393 Following Assistant Professor at Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University. Research focus on organic synthesis.
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88 Followers 289 Following Chem PhD Student @kbrownlab @IUBloomington | M.S. @USFCA | B.S. @Stanford | Long Distance Runner 🏃♂️ | A Big Fan of Coffee! ☕️ #firstgen 🏳️🌈
J @Justus974161
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Sahil Mishra, medicin.. @SahilMi56071146
227 Followers 2K Following #syntheticorganicchemist, #totalsynthesis, #medicinalchemist, #moleculardocking, #molecular dynamics, #QSAR, #research associate, #learning Blockchain
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WindChasing @GemMedX
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490 Followers 4K Following Int. Ph.D. at Indian Institute of Science, Bangalore
J. Am. Chem. Soc. @J_A_C_S
159K Followers 9K Following Research, news, and information from the Journal of the American Chemical Society.
Carolyn Bertozzi @CarolynBertozzi
77K Followers 3K Following Prof. @StanfordUChem; Baker Family Director, @Stanford_ChEMH; @HHMINews Investigator; EIC of @ACSCentSci; She/Her 🏳️🌈
Angewandte Chemie @angew_chem
102K Followers 3K Following Angewandte Chemie, a journal of the German Chemical Society (GDCh, @GDCh_aktuell) - a leading journal in #chemistry published by @WileyVCH in @Weinheim
J Org Chem/Org Lett @JOC_OL
42K Followers 461 Following JOC and OL serve as the leading international forums for communicating important research in all branches of the theory and practice of organic chemistry.
Total Synthesis @TotalSynthesis
15K Followers 1K Following @SoufianTibouti thinks Nature is the ultimate chemist.
Chemjobber @Chemjobber
45K Followers 6K Following 1. A blog 2. Towards a quantitative understanding of the quality of the chemistry job market | #chemjobs: permanent industry/academia, #chempostdoc: postdocs
Song Lin Lab @SongLinLab
9K Followers 918 Following Electrifying organic chemistry since 2016 | Cornell University | Student-run account
Engle Lab @EngleLab
9K Followers 218 Following catalysis, reaction discovery, and samoyed sled racing @scrippsresearch. views our own.
AggarwalLab @AggarwalLab
9K Followers 211 Following Synthetic organic chemistry group focused on the incorporation, homologation and functionalisation of organoboron compounds. Group ran account.
MaulideGroup @MaulideLab
14K Followers 483 Following Research group based in Vienna. Organic synthesis and methodology
Sarpong Group @SarpongGroup
9K Followers 469 Following Student-run twitter account for the Sarpong group at UC-Berkeley.
David MacMillan @dmac68
12K Followers 50 Following Scottish chemist with a great wife, three annoying kids and a “unique” mother-in-law. Location is 100% aspirational 100% of the time
Mark Levin @LevinChem
9K Followers 2K Following Associate Prof @UChiChemistry @group_levin Single-Atom Skeletal Editing Husband to @Lucia_Petito Dad to 👶👶 🐶 Views my own
L.-C. Campeau Ph.D. @DrLCsquare
8K Followers 1K Following Head of Small Molecule Process R&D at Merck. Trying to change the world, 1 reaction at a time. Fellow of the Royal Society of Canada. Cohost @PharmToTablePod
Jake Yeston @JakeYeston
10K Followers 3K Following Editor @sciencemagazine, left this God-forsaken site for bluer pastures (https://t.co/EPRofYnUOm)
Waser Group @LcsoLab
12K Followers 6K Following Driven by Passion for Chemistry Organic Chemistry Lab @EPFL_CHEM_Tweet @EPFL_en @NCCR_Catalysis @NCCR_ChemBio
Yulab @YulabJin
12K Followers 500 Following breaking one CH bond per day...keeping headaches away...
Chemical Science @ChemicalScience
91K Followers 3K Following Flagship journal for @RoySocChem, open access with no publication fees, for the breadth of the chemical sciences. [email protected]
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16K Followers 12K Following Penn Integrates Knowledge Professor, Natural Product Aficionado, Photopharmacologist, Fox Terrierist, and Unfulfilled Architect. #firstgen
Michael Trakselis @Trakselis
723 Followers 650 Following Director of Graduate Affairs; DNA Replication and Repair Mechanisms; Cancer Biology; Infertility Baylor University; other interesting things
Aaron Wright @WrightGroupBU
199 Followers 176 Following News from the Wright Group at Baylor. Departments of Biology and Chem & Biochem. ChemBio and Microbiome research. Schofield Endowed Chair in Biomedical Science
Derosa Lab @derosalab
579 Followers 41 Following Research group @BUChemistry interested in catalysis, organic synthesis, organometallic chemistry, and electrochemical methods.
Stanley Goldstein @broteomix
113 Followers 247 Following Pharmacology PhD Candidate @PharmBU. One-man proteomics shop for @porco_lab and inaugural member of @BU_TDL.
Max Palkowitz @mx_million
952 Followers 726 Following Medicinal Chemist at Bristol Myers Squibb // PhD with @baranlabreads // Amateur Athlete with Team BAA 💛💙
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2 Followers 122 Following
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24K Followers 1K Following Associate Professor of Chemistry| College of the Holy Cross| Organic Methods| Tennis and Karaoke lover 🏳️🌈 (he/him)
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740 Followers 1K Following Assistant Professor in Organic Chemistry at Ole Miss
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4K Followers 759 Following 🇨🇦 Investigating and developing novel transition-metal-catalyzed organic transformations. insta: @theorderoflautens
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203 Followers 229 Following One part father, one part chemist, one part foodie, one part dog owner, one part history buff, one part coffee connoisseur, and now I’m out of parts.
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30 Followers 250 Following Graduate student with @JohnWoodGroup; Interested in natural products synthesis; ShanghaiTech Alumni; Sarlah Lab Alumni @SarlahLab.
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Reggie Mills @reggiemills28
665 Followers 620 Following Banting Postdoctoral Fellow in the @ChirikGroup, Princeton; Ph.D. 2020 from U. of Toronto with @RousseauxGroup
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Chuan Shan 单川 @ChuanShanUP
289 Followers 1K Following Crystallographer sitting between small molecules and proteins, Synthetic Organic chemist finding his way, apprentice NMR spectroscopist
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
Chris Chang @christhechang
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Congrats to my @UMNChemistry in the @robertsgroupumn ! I have really been enjoying hearing about their aryne chemistry over the past semester!
🚨 Our first Science paper 🚨 We report the isolation and reactivity of the first “inaccessible” 5-membered heteroaryne! 120+ year challenge! Congrats @jennahumke @belli_roman @ErinPlasek @Sal_K_3 @annabelly24 @CortnieRoberts @UMNChemistry @ScienceMagazine science.org/doi/10.1126/sc…
@VividionRx Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase | Nature nature.com/articles/s4158…
My 5th time in last 2 years volunteering at @IUBloomington care week.. @IUHoosiers come and get free food, cuddle puppies 🐕 and many more! #communitywork #phdlife #volunteer
We're excited to share that the lab has been awarded a shiny new toy! Very grateful to @shimadzussi for an Early Career Equipment Grant, which has enabled us to acquire a UPLC! #newlab #chemtwitter #LCMS derosalab.com/post/lab-award…
today we had a chance to celebrate Dr. Feng Yang, who will be leaving us soon for a position at Boehringer Ingelheim. Congratulations Feng on your excellent work!
Congratulations to Holly McAnlis, Hanna Warinner, and Angel Borge for passing their 2nd year qualifying exams ! I am very proud of all of you and the excellent chemistry that you are developing!
The most understood result of clamping is translation inhibition via clamping of eIF4A and (to a lesser extent) DDX3X to mRNA. There’s one rocaglate (Zotatifin) in trials for both cancer and antiviral indications. A major goal is to identify rocaglates that clamp new DDXs.
We started with cell-based PISA assays – these were great for characterizing downstream effects of rocaglate binding, but not ideal for identification of direct targets. We moved to lysate-based assays, which worked quite well after supplementation with key additives.
ATP analogs stimulated RNA binding for ATP-dependent DDXs. RNA-bound DDX targets thus became “rocaglate receptors” suitable for TSAR profiling experiments. We evaluated different temperature, ATP analog, and RNA additive parameters, then profiled some widely used rocaglates.
TSAR profiling revealed FIVE new potential DDX targets amenable to rocaglate-induced clamping! We followed up with limited proteolysis and fluorescence polarization experiments, which showed that the rocaglate clamping spectrum can indeed extend beyond eIF4A and DDX3X.
Congratulations on this excellent work Stan ! We also thank our collaborators at BU, McGill, OHSU, and @PelagoBio for their contributions !
Now on BioRxiv, my first grad paper in the @porco_lab! We modified the proteome integral solubility alteration (PISA) assay by supplementing cell lysates with biomolecule surrogates, enabling detection of rocaglate-induced RNA-protein molecular clamping. biorxiv.org/content/10.110…
Shoutouts to co-authors and mentors! @BU_CMD @McGillBiochem @PelagoBio @CNSB_OHSU
We docked rocaglates against DDX3X to zoom in on structural determinants of binding, providing a basis for rational design of rocaglate analogs. As the PDB fills up with rocaglate-competent DDX structures, we hope to selectively tune rocaglates toward new clamping targets.
Now on BioRxiv, my first grad paper in the @porco_lab! We modified the proteome integral solubility alteration (PISA) assay by supplementing cell lysates with biomolecule surrogates, enabling detection of rocaglate-induced RNA-protein molecular clamping. biorxiv.org/content/10.110…
Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR) biorxiv.org/cgi/content/sh… #biorxiv_biochem
(BioRxiv All) Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR) dlvr.it/T5m0tT (RSS) #BioRxiv #MassSpecRSS
Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR) biorxiv.org/content/10.110…
Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR) biorxiv.org/cgi/content/sh… #bioRxiv
Great visit from @NoelGroupUvA . Superb lecture, and super company at dinner. We had plenty of wine! @BristolChem
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