StackWave @stackwave

Simplifying Software for the Life Sciences. stackwave.com Joined May 2011

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StackWave @stackwave

2 years ago

We want to express our gratitude to everyone who attended our presentation at #AET23 this year: Software at Every Stage: Achieving Antibody Discovery at Scale. Your presence made it a tremendous success! 🙌 #StackWave #AntibodyDiscovery #Innovation

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StackWave @stackwave

2 years ago

#AET23 Scientific Briefing - Software at Every Stage: Achieving Antibody Discovery at Scale 12/14 at 1:45pm PST bit.ly/3GFljBB

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StackWave @stackwave

2 years ago

Data is essential to developing new medicines, but managing it can be a challenge. Bioregistries support modeling, recording, and querying data at scale to simplify management and make data more FAIR. #biotech #antibodydiscovery #drugdiscovery bit.ly/40ZOGYZ

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StackWave @stackwave

2 years ago

Phage display enables screening and selection of molecules with desired binding properties. It has revolutionized the discovery of #nanobodies. See how to prepare a phage display library for nanobody discovery. #antibodydiscovery #biotech #drugdiscovery bit.ly/46qM3QV

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StackWave @stackwave

2 years ago

5 issues during cDNA library preparation for NGS (and solutions): 1. Poor quality RNA 2. Inefficient reverse transcription 3. Low cDNA yield 4. Adapter dimer formation 5. Inconsistent fragment size #ngs #cdna #biotech #antibodydiscovery #drugdiscovery bit.ly/3SKcWMo

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StackWave @stackwave

2 years ago

NGS has transformed fields like genomics, transcriptomics, and immunology. It enables efficient identification of VHH regions from B-cells. This article explores NGS for antibody identification and VHH extraction. #nanobodies #ngs #drugdiscovery #biotech bit.ly/3FT272Q

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StackWave @stackwave

2 years ago

Scientists harness #nanobodies to combat viral and bacterial infections, using their small size to access viral and bacterial components larger molecules might not reach, such as the spike protein of SARS-CoV-2. #antibodydiscovery #biotech #drugdiscovery bit.ly/3Spj10x

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StackWave @stackwave

2 years ago

Scientists explore the potential of #nanobodies for treating neurodegenerative diseases. They are small, stable, specific molecules that show promise in clearing accumulated proteins and preventing cell death. #antibodydiscovery #biotech #drugdiscovery bit.ly/3tUYO8Z

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StackWave @stackwave

2 years ago

#Nanobodies: Promising weapons in the fight against cancer. These small, stable, highly-specific antibody fragments show enormous potential in targeted therapy through various mechanisms of action. #antibodydiscovery #biotech #drugdiscovery bit.ly/3QDyvgo

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StackWave @stackwave

2 years ago

#Nanobodies: small, stable antibody fragments derived from camelids. High potential in diagnostics, imaging, and therapeutics. Unique properties: small size, high stability, specificity, low immunogenicity. #antibodydiscovery #biotech #drugdiscovery bit.ly/470WMSL

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StackWave @stackwave

2 years ago

#ngs technology has revolutionized #antibodydiscovery. Bulk B cell sequencing enables analysis of the antibody repertoire and identification of therapeutic antibodies. This blog post explores bulk B cell analysis via NGS and its role in antibody discovery. bit.ly/3Fs2EbU

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StackWave @stackwave

3 years ago

Read about the current state of knowledge of FcRn–IgG immunobiology, with an emphasis on the functional and pathological aspects, and an overview of FcRn-targeted therapy development. #AntibodyResearch #Biotech go.nature.com/40McRcB

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StackWave @stackwave

3 years ago

Part 3 of the DrugOps blog series talks about the power of using software to orchestrate the steps in drug discovery workflows #AntibodyDiscovery bit.ly/40YDgEs

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StackWave @stackwave

3 years ago

Moderna acquires a synthetic biology specialist, OriCiro, which launched in December 2018. Its technology offers “a highly strategic fit with @moderna_tx” #Biotech bit.ly/40M7A4T

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StackWave @stackwave

3 years ago

Bristol Myers CMO, others still skeptical about cancer vaccines as @BioNTech_Group, @moderna_tx march ahead with I-O partners bit.ly/3x7tYYZ #Therapeutics #Pharma

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StackWave @stackwave

3 years ago

Purple Biotech to paint with Immunorizon's tri-specific antibodies in small M&A deal bit.ly/40Gt3ft #AntibodyResearch #AntibodyDiscovery

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StackWave @stackwave

3 years ago

Singapore’s drug discovery efforts reached a new milestone as EBC-129, the first made-in- Singapore antibody-drug conjugate, was cleared by the US FDA to progress into first-in-human studies. #AntibodyDiscovery

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StackWave @stackwave

3 years ago

Researchers have generated more preclinical evidence that intranasal delivery can get antibodies to the brain, presenting data that suggest the administration route can achieve concentrations close to those provided by invasive intrathecal infusions. bit.ly/3l0y2Yc

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StackWave @stackwave

3 years ago

Another issue is data ‘leakage’: overlap between the data used to train a model and the data used to test it. But medical databases can include entries for the same patient, duplications that scientists who use the data might not be aware of. go.nature.com/3j3rgjX