When we think of recessive conditions, rare monogenic disorders come to mind. Yet variants have recessive effects on common diseases too! We profiled the single-variant recessive landscape of a cohort of 44k British South Asians, now live on medRxiv: (1/11)
When we think of recessive conditions, rare monogenic disorders come to mind. Yet variants have recessive effects on common diseases too! We profiled the single-variant recessive landscape of a cohort of 44k British South Asians, now live on medRxiv: (1/11)
The additive model is usually adopted for a GWAS, where the number of risk alleles is assumed to have a linear effect on a trait. In recessive testing, we re-encode genotypes to differentiate only the homozygotes. (2/11)