Bradley James Baker @BakerLabKIST
I am a neuroscientist in Korea that develops genetically-encoded fluorescent voltage sensors Joined September 2016-
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Followers146
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Following120
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Interesting. Inputs to the sleep homeostat originate outside the brain jneurosci.org /content/early/2022/06/07/JNEUROSCI.2113-21.2022
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Gaining insights into how a protein responds to voltage yielded an improved GEVI Conserved Amino Acids Residing Outside the Voltage Field Can Shift the Voltage Sensitivity and Increase the Signal Speed and Size of Ciona Based GEVIs frontiersin.org/article/10.338…
Insights into the photo physics of fluorescent proteins and an easy to use GEVI biorxiv.org/cgi/content/sh…
Our recent effort resulted in an improved GEVI and suggests that trafficking motif interactions persist upon membrane delivery. doi.org/10.1016/j.bpr.…
Our efforts to monitor neuronal activity from different cell types is now online. links.email.frontiersin.org/ls/click?upn=D…
Our second paper confirms interaction between neighboring GEVIs resulting in a new family of probes. Improving the flexibility of genetically encoded voltage indicators via intermolecular FRET cell.com/biophysj/fullt…
We have two papers out today. This one yields insights into charge transfer from the exterior of an FP to the internal chromophore. Mechanism of ArcLight derived GEVIs involves electrostatic interactions that can affect proton wires cell.com/biophysj/fullt…
Our improved understanding of GEVIs has led to a new family type utilizing intermolecular FRET | Home doi.org/10.1016/j.bpj.…
One of two recent efforts exploring the mechanism of GEVI photo physics. AddThis | Home doi.org/10.1016/j.bpj.…
Our latest is out. GEVI cell‐type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area onlinelibrary.wiley.com/doi/10.1111/ej…
Our latest effort thanks to colleagues in Japan and Greece. pubmed.ncbi.nlm.nih.gov/33675122/
Our recent effort exploring the mechanism voltage dependent fluorescence change has posted. biorxiv.org/content/10.110…
Bradley James Baker retweeted
Proton wires mediate the optical signal for ArcLight-type Genetically Encoded Voltage Indicators biorxiv.org/cgi/content/sh… #biorxiv_biophys
A nice example of how manipulating the voltage range can increase the signal size of GEVI biorxiv.org/cgi/content/sh…
Our new GEVIs have posted. Improving the flexibility of Genetically Encoded Voltage Indicators via intermolecular FRET biorxiv.org/content/10.110…
Our latest review is out. Biophysical Parameters of GEVIs: Considerations for Imaging Voltage sciencedirect.com/science/articl…
Our most recent paper developing a true photoactivatable GEVI. frontiersin.org/articles/10.33…
However, ArcLight can resolve action potentials: Optical consequences of a genetically-encoded voltage indicator with a... sciencedirect.com/science/articl…
Genetic light bulbs illuminate the brain nature.com/articles/d4158…
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