Big Tree Jianzhi Zeng @BigTree_Zeng
Chongqinger, PKUer, Yulong Li lab, fly pusher, sensor seller Joined February 2019-
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(1/3) Exciting news! Introducing highly selective next-generation norepinephrine (NE) GRAB sensors! Our optimized fluorescent NE sensors possess 1000-fold selectivity over DA and a 4-fold increase in behavior-stimulated in vivo signals compared to previous prototypes.
1/3 New serotonin (5-HT) GRAB sensors! We developed largely-improved green and all-new red genetically encoded fluorescent 5-HT sensors for dual-color imaging in vivo. Using these new 5-HT sensors, we are able to simultaneously monitor 5-HT and other neurochemicals.
thank you @elfylandstudios for this beautiful illustration of flies finding each other using smell. check out the full story here doi.org/10.1016/j.cell…
Officially started my first week @WUSTLneurosci. Lab website is up and we will hire at all levels very soon! Plz spread the word and stay tuned😄#newPI sites.wustl.edu/huanglab/
We are thrilled to share our latest biological finding published with @NeuroCellPress that "Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning"! Big congrats to @BigTree_Zeng, @XuelinLi1! Check it out authors.elsevier.com/a/1gUa03BtfH1Z…
1/4 New discovery from Yulong Li Lab! We found that 5-HT regulates the coincidence time window of one-trial olfactory learning in both behavior and circuitry plasticity levels. #coincidence time window #olfactory_learning #GRAB_sensors
China has lifted its 76-day lockdown on Wuhan! The city is now recovering from the outbreak, and slowly returning to normal. The day before, we also welcomed home the return of #PKU affiliated hospital medical workers, who formed the relief teams that had been stationed in Wuhan.
First twitter not about science. Can anyone tell me what cultural or historical reasons making people in some area intuitively refusing to wear face mask? By knowing the #CODVID19 attacking respiration system, I feel it is a common sense. No offense. No offense. No offense.
It's a difficult time & stay safe! We'd like to share this preprint, which we've been working on for quite a long time, about new red and optimized green fluorescent GRABDA sensors. Great collaboration with NYU Dayu Lin lab @moccalin & NIH Guohong Cui lab. #GRABSensors #dopamine
It's a difficult time & stay safe! We'd like to share this preprint, which we've been working on for quite a long time, about new red and optimized green fluorescent GRABDA sensors. Great collaboration with NYU Dayu Lin lab @moccalin & NIH Guohong Cui lab. #GRABSensors #dopamine
2/4 Based on our previous effort in engineering GPCR-Activation Based ACh sensor (GRAB-ACh), here we optimize its performance to achieve significant improvement on dynamic range and SNR in detecting ACh, and with negligible coupling with GPCR downstream pathways.
GRAB Ado1.0 enables the detection of adenosine dynamics in vivo during acute hypoxia. Check yulonglilab.org/resources.html to get GRAB-Ado and other #GRABSensors. #NobelPrize
#cshldros This year’s CSHL drosophila meeting is superb! ! ! So many great talks and posters! If you missed my poster, here is a take-home : the ‘FRET-opsin’ voltage sensors from Schnitzer lab and Pieribone lab work super good in many types of neuron in alive fly! Try them!
Our improved dopamine sensor GRAB-DA2m shows higher in vivo response and SNR than DA1m (Sun et al Cell 2018). #GRABSensors
Direct observation of novelty induced dopamine release from single dopaminergic neuron in vivo. #dopamine #GRABSensors
Patients with liver diseases often suffer from chronic itch, yet the mechanism remains largely elusive. In this pre-print paper, we report a ligand-receptor pair, bile acids and MRGPRX4, an orphan primate specific GPCR, underlying cholestatic itch. biorxiv.org/content/10.110…
A Genetically Encoded Fluorescent Sensor Enables Real-time Detection of the Intracellular GTP:GDP Ratio biorxiv.org/content/10.110… cpGFP(YFP)とeIF5Bを用いたGTP/GDP sensor、GNEPSの開発。GTPが結合すると蛍光強度が上がる。
1/2 Norepinephrine is an important neurotransmitter in the brain regulating sensory infromation processing, sleep/arousal state and attention. Excited to share our new GRAB sensors for NE published on Neuron @NeuroCellPress today. cell.com/neuron/fulltex…
Almas Serikov @AlmasSerik50267
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haosuyuyu @haosuyuyu
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The Innovation | Medi... @Innov_Medicine
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Yang Xiao @YangXiaoBME
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Yu Mu @muyuuyum
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Sha Liu 刘沙 @flysleeplab
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Xinnan Wang Lab @XinnanwangL
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Xiaochun Cai @Xiaochun_Cai
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Mona Lee @Kelvin519025441
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Alice @jiukuan88999
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Yuwei Zhu @Yvainezhu
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玉衡-Alioth @Alioth_Laurent
611 Followers 409 Following PKU, physics. Trying to learn some mathematical physics | Trying to learn 日本語 и Русский язык | Slightly furry🐱 | former cdqzer ｜🌈 想脱单呜呜
Bradley James Baker @BakerLabKIST
146 Followers 120 Following I am a neuroscientist in Korea that develops genetically-encoded fluorescent voltage sensors
Bohan Zhao @BohannZhao
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Bohan Li 李柏翰 @BohanLi_PKU
40 Followers 140 Following Undergraduate from @PKU1898/ Graduate student in Yulong Li lab@PKU/ Purinergic transmission/Biotech development
Hyungseok C. Moon @CHyungseok
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Hongxia Li @Hongxia_Li2017
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Yuxuan Liu 刘雨轩 @YX_Liu_PKU
190 Followers 438 Following PhD stu. of @RiceUniversity #RiceNEI || @PKU1898 alumnus.|| Research: Neuroengineering, BCI, Computational Neuroscience.|| Swimming, ACG, travelling.
Sakurai @Sakurai68955214
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Mladen-Roko Rasin @RasinRoko
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Scarlet Park, PhD @scarletjpark
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Zhaofa Wu @ZhaofaW
100 Followers 192 Following Principal Investigator @ IGDB, Chinese Academy of Sciences PhD & Postdoc @ Yulong Li Lab, Peking University
Youran Yang 杨悠然 @yang_youran
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Yi (Eason) SHEN 沈�... @easonyshen
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Dr. Samer Hattar @SamerHattar
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LoogerLab @LoogerL
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Almas Serikov @AlmasSerik50267
1 Followers 3 Following
Eunji Kong @eunji_kkong
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Yu Mu @muyuuyum
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Yu Li @YuLi_01210
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Yuxuan Liu 刘雨轩 @YX_Liu_PKU
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Prof. Michael Lin @MichaelLinLab
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Shan Meltzer @shanmeltzer
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Steph Cragg @StephCragg
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Abhi Aggarwal @abhi_aggarwal1
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Sha Liu 刘沙 @flysleeplab
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Cahir O'Kane @OKaneCahir
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Xiaochun Cai @Xiaochun_Cai
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Bohan Li 李柏翰 @BohanLi_PKU
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Ruichao Eric Liu @purkinje_liu
150 Followers 722 Following Ph.D candidate at @Tsinghua_Uni | studying neuro-immune crosstalk in @CChu_89 lab
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Dana Galili @GaliliDana
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