Mission: Use Magic to filter, Nonsense!🧹 It's magic!✨Electric Engineer/ Communication Engineer| Tinkerer| Chess|Human| Science History Collector| Unicycle
#SPDsites.google.com/view/scienceco… Dresden, DeutschlandJoined March 2019
"Only ~0.02%-3.1% of [a cell's] genome" is being transcribed at any given moment.
Other interesting takeaways from this new paper:
> If you pool together a bunch of cells of the SAME type (like primary immune cells from a mouse's spleen), and you measure the transcription for…
astrocyteのLeafletはIP₃R1依存性Ca動態により複数synapse入力を時空間統合する第2の計算systemである
astrocyteは太いshaftと薄いleafletの二層構造を持ち、leafletがgap結合でdomainを形成してclusterのsynapseを90%包み込む
OA
#synapse#astrocyte#paperscell.com/cell/fulltext/…
They might keep stealing my images, and I might keep complaining 😬, but I will continue sharing my work here. This is science produced with public funding, and the public deserves to know how the money is being used. This is an image of a blood vessel in the brain🔬 1/3
A myelination-independent role of oligodendrocyte precursor cells in brain aging, with declined autophagy driving CCL3/CCL5/CCR5 signaling & aging-associated cognitive decline @ScienceAdvances 🇨🇳
science.org/doi/10.1126/sc…
In most cells of your body, mitochondria are constantly in movement.
They interact with one another like social creatures do, exchange information, sometimes fuse to become longer and bigger, and then fragment to die off and be recycled.
Mitochondria move and are dynamic…
Removing Drp1 in mouse zygotes disrupts mitochondrial distribution, spindle formation & embryo development, revealing how vital this protein is for early life.
elifesciences.org/articles/99936…
Our study @ImmunityCP uncovered rod-shaped microglia as key responder to cortical hyperactivity in TDP43 neurodegeneration. These specialized microglia align with dendrites, remodel synapses, and provide protection via TREM2 signaling. Thanks @Manling_Xie for the leading efforts!
Our study @ImmunityCP uncovered rod-shaped microglia as key responder to cortical hyperactivity in TDP43 neurodegeneration. These specialized microglia align with dendrites, remodel synapses, and provide protection via TREM2 signaling. Thanks @Manling_Xie for the leading efforts! https://t.co/JufQYCKJLk
Can stem cells help to regain brain function after stroke?
Our new study in @NatureComms shows that they can and dissect the key mechanisms driving recovery.
(Took us 'only' 5 yrs to find out😀)
1/10 🧵
A rather 'unique' paper from our lab is online in @CellReports now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!
doi.org/10.1016/j.celr…
Endothelin signalling acts as a natural brake on nerve regeneration. Blocking it with the FDA-approved drug Bosentan restores axon regrowth, even in older animals where repair capacity normally declines.
elifesciences.org/articles/10021…
BBBに関する包括的な総説
脳の恒常性維持に必須の構造で/内皮/周皮細胞/astrocyteが協調して機能する
scRNAseqにより動静脈軸での分子的多様性が明らかになり加齢や神経変性疾患でのBBB機能変化が病態に深く関与するし認知症の早期biomarkerとして有用
OA
#BBB#papersdoi.org/10.1093/brain/…
Delighted to see not one, not two, but three papers about astrocytes in Science today! Here's our contribution to that collection.
Come follow us on bluesky! Papouin lab twitter/X: over & out...
science.org/doi/10.1126/sc…
How do cells clean up misfolded proteins when they divide?
This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved.
elifesciences.org/articles/96675…
1K Followers 870 FollowingAssociate Professor at Grad Sch Med, Nagoya Univ, Japan. Interested in how #microglia contribute to brain development.
名古屋大医・准教授、脳発生・脳内免疫細胞ミクログリアの機能について研究してます。
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2K Followers 917 FollowingAstrocyte Cafe is a virtual seminar series for #astrocyte researchers, organized by @CarmenFalcone6 and @NGunhanlar. Join us by subscribing: https://t.co/Fiw4fTJEON
10K Followers 11K FollowingObsessed with Mitochondria & Optogenetics/Anti-Aging Ringleader/Longevity Chaser/Aging is inflammation/Philosophy, Art, Music & Love make existence bearable
32K Followers 12K FollowingPhysicist and Science Writer. Author of eighteen books, most recently The Allure of the Multiverse: Extra Dimensions, Other Worlds, and Parallel Universes
2K Followers 2K FollowingNeurology department University Hospital of Zurich🇨🇭Group leader- ZNZ Zurich/ Cerebrovascular/ Blood flow/ Stroke 🧠 Science moved to Twitter, I moved too!
66 Followers 401 FollowingPhD. I process data and make EP cardiac computer models in a small research lab. I share here my reading list and favorite tools.
77K Followers 13K FollowingNewsletter exploring AI&ML - AI 101, Agentic Workflow, Business insights. From ML history to AI trends. Led by @kseniase_ Know what you are talking about👇🏼
7K Followers 321 FollowingPresidential Associate Professor @Penn - using AI to reimagine antibiotic discovery and peptide design. Previously @MIT, @UBC
3K Followers 104 FollowingI make mathematics and physics animation videos on YouTube
BSc, MSc, Maths & M. Eng ECE
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567 Followers 165 FollowingThe De Biase lab studies how microglia shape normal and pathological circuit function using imaging, electrophysiology, and molecular biology approaches.
12K Followers 11K FollowingCardiovascular biologist @WesternU PhD @UCalgary BSc @PKU1898
Views are my own
Developmental Biology Social media editor @Dev_Bio_Journal
Just call me Hao (How)
2K Followers 2K FollowingAsst Prof @KeckMedicineUSC @USC with interest in the brain, BBB, stem cells, AI + what can go wrong after stroke & AD. Alum @ETH_en @UZH_en Editor @ResearchHubF
97K Followers 8K FollowingCompiling in real-time, the race towards AGI.
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1K Followers 870 FollowingAssociate Professor at Grad Sch Med, Nagoya Univ, Japan. Interested in how #microglia contribute to brain development.
名古屋大医・准教授、脳発生・脳内免疫細胞ミクログリアの機能について研究してます。
11K Followers 7K FollowingResearch lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
@labwaggoner.bsky.social
7K Followers 5K FollowingBridge the gap between IT&OT. Bring MORE (Modular,Open,Reliable, Efficient ) Controller to Industries #IoT #Arduino #Jetson #Raspberrypi #PLC #Automation
2K Followers 2K FollowingAstrocyte lover. Assistant professor at @UMBCBiology. Excited about sex differences, TBI & BBB. Scientist in the US. Woman in Science 🇪🇦
12K Followers 1K FollowingCreator of https://t.co/w1Pz4s2EhV and a long time computer performance nerd.
Performance & Troubleshooting Training: https://t.co/lRKHSCFE6M
9K Followers 2K FollowingDedicated to understanding the mechanisms underlying learning and memory and related brain functions and disease. Profile art by @toddsiler
880 Followers 671 FollowingChair of Theoretical Chemistry @tudresden_de of prof. @ThomasHeine14 with @DorotheaGolze Emmy-Noether and Rico Friedrich @DRESDEN_concept junior groups
11K Followers 395 FollowingOfficial feed of @Stanford Wu Tsai Neurosciences Institute. Unlocking the mysteries of brain and behavior through cross-disciplinary research.
615 Followers 237 FollowingSometimes I build robots, admire buildings, and run triathlons | ex @sonos @dufflstores. See highlights for projects. DMs open
141K Followers 39 FollowingSan Diego Dec 2-7, 25 and Mexico City Nov 30-Dec 5, 25. Tweets to this account are not monitored. Please send feedback to [email protected].
495K Followers 152 FollowingNobel Laureate. Co-Founder & CEO @GoogleDeepMind - working on AGI. Solving disease @IsomorphicLabs. Trying to understand the fundamental nature of reality.
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