Martin Picard @MitoPsychoBio
Mitochondrial Psychobiology. Our team studies energy, mind-body communication, mitochondrial diseases, aging, and the science of health. picardlab.org Manhattan, NY Joined February 2018-
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Just published! My attempt to make sense of how the autonomic system can shift so dramatically in aging without negatively influencing mood and well-being. nyaspubs.onlinelibrary.wiley.com/doi/10.1111/ny…
Great convo between two top neuroscientists, Dr. Picard @MitoPsychoBio and Dr. Mattson. I learned we are warm-blooded due to mitochondria, free intact mitochondria are in the saliva/blood, and glia are most affected by psychosocial experiences. youtube.com/watch?v=DWTvq_…
50 doctors, 50 personal trainers and 50 dietitians were asked: "When someone loses weight, where does it go?" Only 2 dietitians got the right answer = you breathe it out as carbon dioxide and water 0 doctors said "I don't know" This explains A LOT 😂😂
Many mental-health conditions have bodily triggers economist.com/science-and-te… this is such an important topic. and the reverse is likely also true: bodily ailments and affect the brain
The microscopic world is pretty special and beautiful
The microscopic world is pretty special and beautiful
Like many endocrine factors in the human body, the hormone GDF15 is also regulated by the mind
Like many endocrine factors in the human body, the hormone GDF15 is also regulated by the mind
Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases biorxiv.org/content/10.110… a very exciting piece of work from @MitoPsychoBio & team
Over-prescribing based on symptoms is risky — clinically and societally. Drugging all of our ailments pulls us away from the true causes of dis-ease, can dysregulate the organism in unpredictable ways, and interfere with healing.
Over-prescribing based on symptoms is risky — clinically and societally. Drugging all of our ailments pulls us away from the true causes of dis-ease, can dysregulate the organism in unpredictable ways, and interfere with healing.
Hypermetabolism and energetic constraints in mitochondrial disorders (2024) @MitoPsychoBio picardlab.org/uploads/7/7/8/…
Profound, honest words by Tom Insel @thomasinselmd - former director of the US National Institute of Mental Health (NIMH)
Profound, honest words by Tom Insel @thomasinselmd - former director of the US National Institute of Mental Health (NIMH)
The cellular hardware is somewhat generic, so complex dynamical systems can use different combinations of available hardware to achieve end goals. Beautiful demonstration in sensory neural circuits built with cells from two different species.
The cellular hardware is somewhat generic, so complex dynamical systems can use different combinations of available hardware to achieve end goals. Beautiful demonstration in sensory neural circuits built with cells from two different species.
Interesting theory on the role of the brain and nervous system, from Aldoux Huxley's The Doors of Perception: "The function of the brain and nervous system is to protect us from being overwhelmed and confused by this mass of largely useless and irrelevant knowledge, by shutting…
Diagnoses are frequently wrong or imprecise. Receiving a medical diagnosis of a serious illness can in some cases have the same effect as bullying, acting as a continuous reminder that something is wrong with you. Even if not true, it ends up affecting the mind and body.
Diagnoses are frequently wrong or imprecise. Receiving a medical diagnosis of a serious illness can in some cases have the same effect as bullying, acting as a continuous reminder that something is wrong with you. Even if not true, it ends up affecting the mind and body.
Isn't sedentariness the default "control" in mouse studies - animals with unlimited access to food in a shoebox without the need nor possibility to be active as they would normally? Makes you wonder if calorie restriction mainly works by matching food to activity level.
The selection for mtDNA variants is dependent on the metabolic environment and acts within just a few cell divisions - not years or millennia Beautiful work @VamsiMootha
The selection for mtDNA variants is dependent on the metabolic environment and acts within just a few cell divisions - not years or millennia Beautiful work @VamsiMootha
Two mitochondria kissing near the Z-line in a skeletal muscle myofiber Note the convergence of cristae and electron density at the site of the "kiss"
Two mitochondria kissing near the Z-line in a skeletal muscle myofiber Note the convergence of cristae and electron density at the site of the "kiss" https://t.co/kjjCod3SUq
There is remarkable mitochondrial diversity and specialization expressed in static molecular features all the way to mitochondrial morphology, functions and behaviors
There is remarkable mitochondrial diversity and specialization expressed in static molecular features all the way to mitochondrial morphology, functions and behaviors
The marker of energetic stress (and perhaps other things) GDF15 foreshadows dementia by over a decade go.nature.com/3wg2KCg
FrezzaLab @FrezzaLab
25K Followers 3K Following We are a group of metabolism-lovers, focused on mitochondrial metabolism. Tweets are from Christian. https://t.co/EbWsJo6DnZMitochondrial Medicin.. @Mito_Therapy
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47K Followers 477 Following Cell Press journal publishing cutting-edge research in metabolism biology, from molecular/cellular biology to translational and clinical studies.Minczuk Lab @mito_gene
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9 Followers 40 FollowingNo evidence for metabolic adaptation during #exercise related #energy compensation sciencedirect.com/science/articl…
Life Metabolism is 2 years old. Come and follow us @lifemetabolism2 and also consider sending us your interesting papers on anything related to metabolism. While you are considering, remember we have no page charges.
@BiggestComeback It's difficult to separate these because what you eat will strongly affect how much you eat.
"I think the most important part of science is being prepared to be wrong." —Judith Campisi (1948–2024) cell.com/cell-metabolis…
I’m delighted to be at the #machine+behavior conference organized by @iyadrahwan @JFBonnefon @azimshariff in Berlin representing@nature with my lovely colleague @SamanthaAntusch from @NatureHumBehav
Just published! My attempt to make sense of how the autonomic system can shift so dramatically in aging without negatively influencing mood and well-being. nyaspubs.onlinelibrary.wiley.com/doi/10.1111/ny…
Great convo between two top neuroscientists, Dr. Picard @MitoPsychoBio and Dr. Mattson. I learned we are warm-blooded due to mitochondria, free intact mitochondria are in the saliva/blood, and glia are most affected by psychosocial experiences. youtube.com/watch?v=DWTvq_…
50 doctors, 50 personal trainers and 50 dietitians were asked: "When someone loses weight, where does it go?" Only 2 dietitians got the right answer = you breathe it out as carbon dioxide and water 0 doctors said "I don't know" This explains A LOT 😂😂
Many mental-health conditions have bodily triggers economist.com/science-and-te… this is such an important topic. and the reverse is likely also true: bodily ailments and affect the brain
@manorlaboratory Definitely yes! and probably even seeing it
Presenting metabolomics analyses: what’s in a number? As part of a methods advice series, Meiser and Frezza highlight frequent pitfalls and offers guidance related to designing, processing, and communicating metabolomics analyses @JohannesMeiser @FrezzaLab embopress.org/doi/full/10.10…
Not sure if this is true or not, but I suspect a majority of intellectuals find it easier to argue (often accurately) that some idea is wrong than to put forward their own idea and defend it.
white blood cells crawling between red blood cells
Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases biorxiv.org/content/10.110… a very exciting piece of work from @MitoPsychoBio & team
Could chronic stress be increasing our risk of cancer spreading? Persistent stress and chronic activation of the sympathetic nervous system are known to be associated with negative impacts on our longevity, but a new study, albeit in mice, has identified a possible causal role…
@MitoPsychoBio We will get to the root causes with precision metabolic medicine , built on insights from researchers like yourself and your lab. stay hopeful for the future !
@MitoPsychoBio As the saying goes, a pill for every ill, a cure for none is a great business model. It's not caring.
@JourneyofHope4U @MitoPsychoBio and so difficult to work with clients when the scripts are the only semblance of care they have in their lives
@MitoPsychoBio As a physician I was taught this - always add something on top of all the meds. Couldn’t be more wrong. Time to catch up with the true intention to heal.
The most important criterion for success is to focus on your goal ...