Léa Caya-Bissonnette, PhD @CayaBissonnette
PhD in Neurosciences, University of Ottawa. Synaptic electrophysiology & cortical plasticity. researchgate.net/scientific-con… Joined July 2011-
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Wow, this is great!! Fantastic teaching resource to boot.
Wow, this is great!! Fantastic teaching resource to boot.
For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold! cell.com/current-biolog…
Clustering model parameters across hundreds of synapses, we found five functional subtypes of synaptic dynamics in rodents and six functional subtypes in humans which show qualitative overlap (though based on existing data we don’t expect a perfect overlap). 4/10
MUST read - Amazing work showing functional clusters of short term plasticity! Congrats @jgbeninger 🎉👏
MUST read - Amazing work showing functional clusters of short term plasticity! Congrats @jgbeninger 🎉👏
If you're interested in dendritic computation, our most recent findings are just published! With @Z_Friedenberger and at @NatComputSci Direct access: rdcu.be/duzz9 Online: nature.com/articles/s4358…
I’m pretty overdue but this photo reminds me of this exciting day when I had a chance to moderate the trainee talks along with @CayaBissonnette at Centre for Neural Dynamics Research Spotlight organized by @uOttawaBMRI, & enjoy a beautiful talk by @nspruston back in September!
A new theory of serotonin function: it encodes "cumulative future reward" aka state value biorxiv.org/content/10.110… Compared to dopamine, serotonin is a lot more mysterious
Great piece of work by @efharkin_ on serotonin and value encoding 👏
Great piece of work by @efharkin_ on serotonin and value encoding 👏
@CayaBissonnette @NeuroNaud @JCBeique Great work! We also have a calcium-dependent model of a different aspect of BTSP here: biorxiv.org/content/10.110…, I'd be interested in hearing your thoughts - maybe you can DM me and we can talk over Zoom some time?
@NeuroNaud Very interesting paper, thanks for sharing! So cool that you are also venturing into the molecular world and building a bridge to the circuit level.
Beautiful work by @CayaBissonnette @NeuroNaud @JCBeique Cellular Substrate of Eligibility Traces biorxiv.org/content/10.110…
Intracellular calcium steadily making its overdue comeback to the big stage 🫡🍿
Intracellular calcium steadily making its overdue comeback to the big stage 🫡🍿
Amazing work! Congrats @CayaBissonnette, @NeuroNaud and @JCBeique 🥳🤩
Amazing work! Congrats @CayaBissonnette, @NeuroNaud and @JCBeique 🥳🤩
Outstanding work by great people - a cellular model of eligibility traces! Check it out 🎉
Outstanding work by great people - a cellular model of eligibility traces! Check it out 🎉
Part 2 of my PhD finally published! w/@ranczlab & @ZhiwenNeuron How do feedforward and feedback connections target L5 neurons? 🧵 TLDR; Dendritic targets are tightly specified, but may surprise you. “FF = basal, FB = apical tuft” is not a universal rule! bit.ly/tL5b
What does the serotonin system compute? 🤔 🎉 I'm excited to finally be able to share a long-term project with @JCBeique and @NeuroNaud to create an experimentally-constrained bottom-up model of the dorsal raphe nucleus, just published in @eLife!🎊 doi.org/10.7554/eLife.… 1/13
Super cool results! Glad to see the full paper out after the preview we got at Cosyne
Super cool results! Glad to see the full paper out after the preview we got at Cosyne
How can individual neurons learn to associate events that don't happen at exactly the same time? 🤔 Léa provides a mechanistic answer: synaptic loading and unloading of ER calcium stores. 😲
How can individual neurons learn to associate events that don't happen at exactly the same time? 🤔 Léa provides a mechanistic answer: synaptic loading and unloading of ER calcium stores. 😲
Few-shot plasticity in the cortex unfolds with big calcium events. With these rare events, calcium stores act as temporal buffers, extending the timescale for associating pre&post activity to seconds. But there is much more in Léa's work. Check it out!
Few-shot plasticity in the cortex unfolds with big calcium events. With these rare events, calcium stores act as temporal buffers, extending the timescale for associating pre&post activity to seconds. But there is much more in Léa's work. Check it out!
Possible mechanism of behavioral timescale plasticity!
Possible mechanism of behavioral timescale plasticity!
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