Chem Biol @ChemBiol2
All things chemical biology Joined April 2019-
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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease biorxiv.org/cgi/content/sh… #biorxiv_biophys
Our work on covalent PROTACS is #JustAccepted in @J_A_C_S. We both show cyanoacrylamide reversible covalent PROTACs for BTK, and were able to explain why seemingly irreversible PROTACs also work great. pubs.acs.org/doi/10.1021/ja… 1/
How to you target six functional RNAs with a single ligand? You cleave the precursor to them. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
I am pleased to share our preprint on an FBDD campaign against MTB DHFR. Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis biorxiv.org/content/10.110…
Isoform-selective regulation of mammalian cryptochromes | Nature Chemical Biology - our collaboration with Tsuyoshi Hirota in Nagoya @KECKSchool_USC nature.com/articles/s4158…
Structural basis of receptor recognition by SARS-CoV-2 - Nature nature.com/articles/s4158… #covid19
Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA nature.com/articles/s4146…
Calling all medicinal chemists! We released ~60 structures of fragments bound to the Mpro #SARS_COV_2. diamond.ac.uk/covid-19/for-s… We are crowdsourcing ideas for what to synthesise and test next covid.postera.ai/covid you design it and we'll test the best designs. please RT!
Bifunctional Molecules beyond PROTACs pubs.acs.org/doi/10.1021/ac…
Waw, just out on bioRxiv, crystal structure of AtMC4 and rationale for calcium-dependent activation and cleavage of its in vivo substrate PROPEP1! Structural Basis for Ca2+-Dependent Activation of a Plant Metacaspase biorxiv.org/content/10.110…
Deep mutational scanning reveals the structural basis for α-synuclein activity: nature.com/articles/s4158…
An open-source drug discovery platform enables ultra-large virtual screens | Nature nature.com/articles/s4158…
Hi all, we submitted the #COVIDー19 genome sequence from the viral strain linked to the #GrandPrincess cruise ship off coast of San Francisco to #GISAID. Phylogenetic analysis shows that it clusters with the outbreak clade circulating in Washington State. @UCSF #coronavirus
Federal Agents arrested Dr. Charles Lieber, chair of Harvard University's Dept of Chemistry & Chemical Biology. He recieved secret monthly payments of $50K from China to help set up a chemical/biological “Research” lab in China, Wuhan Univ of Tech. nature.com/articles/d4158…
#OncoAlert NK cells for #cancer #immunotherapy | Nature Reviews Drug Discovery #CARNKcell nature.com/articles/s4157…
Interesting developments coming out now on Carona virus nature.com/articles/d4158… In case you missed it, today, Federal Agents arrested Dr. Charles Lieber, chair of Harvard's Department of Chemistry and Chemical Biology, with lying to the DOD. Corona bio weapon disaster
Rich data sets could end costly drug discovery nature.com/articles/d4158… @segal_eran explains why it’s time to go beyond genetics when developing drugs. Deep Phenotyping including #metabolomics is a better approach.
Behind the scenes part 2: reviving strains. We recently pulled ~750 lyophilized strains in glass ampules 🧪 from our cold room 🥶 and plated them 🧫 to make working stocks. #naturalproducts #bacteria #NPDD @scrippsresearch
#DeepScaffold: A Comprehensive Tool for Scaffold-Based De Novo #Drug Discovery Using Deep Learning pubs.acs.org/doi/10.1021/ac… #ASAP
Bioorthogonal reactions have found widespread use in chemical biology. Here is a brief outlook on the future of the field, outlining emerging areas and key challenges to overcome by Neal K. Devaraj @UCSDChemBiochem: pubs.acs.org/doi/10.1021/ac…
Stephan Hacker @StephanHacker2
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7K Followers 4K Following Professor of Chemical Biology at @Uni_MR. Optochemical tools for controlling biological processes at molecular level. Epigenetic chemical probes. Be Light!✨✨Dan Nomura @DanNomura
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11K Followers 367 Following Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.J. Am. Chem. Soc. @J_A_C_S
159K Followers 9K Following Research, news, and information from the Journal of the American Chemical Society.Ben Schumann @DrGlycoBen
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223 Followers 459 Following Lecturer in Protein Therapeutics @pharmacyatQUB • proteins, polymers and all that cool stuff 👩🏻🔬wstemllc @wstemllc
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5K Followers 2K Following Assistant Professor @LeidenScienceEN. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. Also on https://t.co/OnUZrMJH69 and https://t.co/5xQ0wrIide. he/him/his.Ingo Hartung @HartungIngo
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2K Followers 592 Following 💚🤍💜. Blocks trans hostile terrorists. Cancel culture is a term used by those afraid of accountability. Freedom of speech isn't freedom of consequence.Elisabeth El-Saïeh @ElisabethSaieh
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715 Followers 763 Following Not on Twitter for Likes, RT's, or Follows. Just trying to deal with anger issues in life by sarcasm on posts I see that need some.vijay @Vijaymr94
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1K Followers 3K FollowingCrystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease biorxiv.org/cgi/content/sh… #biorxiv_biophys
Our work on covalent PROTACS is #JustAccepted in @J_A_C_S. We both show cyanoacrylamide reversible covalent PROTACs for BTK, and were able to explain why seemingly irreversible PROTACs also work great. pubs.acs.org/doi/10.1021/ja… 1/
In the latest #SpecialIssue of Cell: a #primer on the design, implementation, and therapeutic and basic research applications of #PROTACs--small molecules that induce protein degradation bit.ly/3bPjuR5
Good read for people interested in PROTACS from @CraigMCrews: cell.com/cell/fulltext/…
Kudos to John Harling and his colleges on their excellent manuscript highlighting the PK/PD of their RIPK2/IAP PROTACs. Really well done! lnkd.in/duCMXRA
Very nice review of ligands to ligand RING E3 ligases. Key reading for PROTAC/degradation junkies. #PFEcolleague lnkd.in/e9qmJ3w
The terpene day continues: A first #PROTAC targeting an E3 ligase with a covalent reversible warhead leads to degradation of target BRD4 plus E3 culprit KEAP1 (via hydrophobic tagging of the latter?): @DanNomura @NovartisScience @ChemGenetics @ChemRxiv chemrxiv.org/articles/Targe…
It's a big day with talks by Aaron Viny about cohesin and chromatin @TheDoctorIsVin @mskcc #BloodandBone and Ben Ebert about targeted protein degradation! @DanaFarber docs.google.com/spreadsheets/d… dfhcc.harvard.edu/events/dfhcc-c…
@WestminsterWAG As a PhD chemist who actually worked in drug discovery research, your tweet is ignorant and harmful. And to think you are the wife of a govt minister, with likely influence, just shows how twisted this unscientific and incompetent govt is.
I’m beyond thrilled to join the chemical biology division of @ChemistryMIT this fall for my graduate studies as a Presidential Fellow! I can’t wait to move to Boston and work on the interface of chemistry and neuroscience! (1/n)
NCI Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library | ACS Chemical Biology pubs.acs.org/doi/10.1021/ac…
Insights into PARP inhibitor-induced cytotoxic PARP1 trapping: Structural basis for allosteric PARP-1 retention on DNA breaks science.sciencemag.org/content/368/64…
Nice PROTAC using Bardoxolone to co-opt Keap1 for BRD4 degradation. Covalent reversible ligands must surely the fastest way to co-opt more of the E3 ligase-ome for PROTAC development. #PFEcolleague lnkd.in/edHedSp
Our latest work w/ #maimonelab & @NovartisScience on discovery of a covalent reversible bardoxolone based E3 ligase recruiter for targeted protein degradation @ChemRxiv ! Congrats to first authors Bingqi Tong & Mai Luo! And thanks to @TheMarkFdn! chemrxiv.org/articles/Targe…
Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone by Daniel Nomura & co-workers doi.org/10.26434/chemr…
Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone [@DanNomura] dlvr.it/RT3fsd
Do people think drug discovery is simple as Juicing right? That any one can just wake up and come up with a drug or vaccination! I wish you knew! But anyway we move.
Now that things are settling into a new "normal," I wanted to share the exciting news that I have accepted Harvard GSAS's offer to join the Chemical Biology PhD program starting this Fall! I am beyond excited to be joining the @chemical_phd family!
Just Published: Spicing Up an Interdisciplinary Chemical Biology Course with the Authentic Big Picture of Epigenetic Research bit.ly/2R7O9kL
How to you target six functional RNAs with a single ligand? You cleave the precursor to them. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…