ShorterLab @ShorterLab
Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn med.upenn.edu/shorterlab/ind… University of Pennsylvania Joined January 2012-
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ShorterLab retweeted
The Sean M. Healey & AMG Center for ALS is excited to announce the recipients of the 2025 ALS Scholars in Therapeutics! This year's recipients are Miriam Linsenmeier, PhD, Elizaveta Okorokova, PhD, and Arens Taga, MD. Congratulations to these inspiring scholars!
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Penn Postdocs in the News: Miriam Linsenmeier, Postdoctoral Fellow, awarded 2025 ALS Scholars in Therapeutics Program Award: postdocs.upenn.edu/news/penn-post…
eIF4E assembly into C. elegans germ granules is essential for its repressive function biorxiv.org/content/10.110…
ShorterLab retweeted
Of course the principle here that you can help people with brain protein misfolding disorders by lowering the expression of the encoding gene is extremely important for the most prevalent untreatable conditions of humans.
Of course the principle here that you can help people with brain protein misfolding disorders by lowering the expression of the encoding gene is extremely important for the most prevalent untreatable conditions of humans.
Tau accelerates tubulin exchange in the microtubule lattice: nature.com/articles/s4156…
ShorterLab retweeted
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The…
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The… https://t.co/GpqBYQtWtz
ShorterLab retweeted
For decades, human genome editing has been limited to small, localized modifications. Today, in a new paper published in @ScienceMagazine, researchers from the @pdhsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
Megabase-scale human genome rearrangement with programmable bridge recombinases | Science science.org/doi/10.1126/sc…
Predicting protein-protein interactions in the human proteome | Science science.org/doi/10.1126/sc…
An inheritance of long life | Science science.org/doi/10.1126/sc…
Lysosomes signal through the epigenome to regulate longevity across generations | Science science.org/doi/10.1126/sc…
Many will enter, few will win: Cost and sensitivity of exploratory dynamics: Biophysical Journal cell.com/biophysj/fullt…
Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders: The American Journal of Human Genetics cell.com/ajhg/fulltext/…
Transcriptome-wide outlier approach identifies individuals with minor spliceopathies: The American Journal of Human Genetics cell.com/ajhg/fulltext/…
The relationship between interfacial overlap and functional divergence in the yeast protein-protein interaction network: Structure cell.com/structure/full…
Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis: Cell cell.com/cell/fulltext/…
ShorterLab retweeted
🚨 A new Huntington’s treatment has shown remarkable results — slowing disease progression by 75%! Huge congratulations to the trial team at @UCLHD, led by UK DRI Group Leader Prof Sarah Tabrizi 👏 Read the full story👉 buff.ly/dsG0FbY
Chromatin Binding Regulates Phase Behavior and Morphology of Condensates Formed by Prion-like Domains: sciencedirect.com/science/articl…
Is amyotrophic lateral sclerosis less severe in mice than humans?: Current Opinion in Neurology journals.lww.com/co-neurology/f…
Design of facilitated dissociation enables timing of cytokine signalling: nature.com/articles/s4158…
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