The Science of Parkinson's @ScienceofPD
Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂 scienceofparkinsons.com London, England Joined January 2016-
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In their multiple N-of-1 trials (n=20) of safety, feasibility, short-term symptomatic & downstream effects of hypoxic conditioning in #Parkinsons, @basbloem et al find it is well-tolerated & modestly improved participant-rated symptoms for several hours nature.com/articles/s4146…
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Researchers report that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum nature.com/articles/s4153…
New research from @kj_brink & colleagues used data from 2 longitudinal cohorts (DeNoPa + ICEBERG; 280 people with early #Parkinsons) to analyse sleep staging; Automated sleep analysis detected microstructural sleep disruptions linked to PD progression nature.com/articles/s4153…
Analysis of the serum metabolome in 69 people with #Parkinsons (& 32 controls) highlights disrupted homeostasis of molecules related to glutamic acid, serine & energy metabolism as distinct serum signatures in PD patients nature.com/articles/s4153…
A new genome-wide association study of REM sleep behavior disorder (RBD) in #Parkinsons (n=13,020) by @ZivGanOr & collaborators highlights genetic distinctions between PD + RBD and PD-RBD, offering insights into PD stratification nature.com/articles/s4153…
Researchers present a novel precision-grip task to assess motor planning deficits in patients with #Parkinsons & mild cognitive impairment nature.com/articles/s4159…
Functional mapping studies reveal robust excitatory input from auditory & temporal association cortices to substantia nigra pars lateralis dopamine neurons, but not substantia nigra pars compacta dopamine neurons, directly regulate threat behaviors nature.com/articles/s4146…
Lys Therapeutics receives $5M grant from @MichaelJFoxOrg to help advance their immunotherapy 'LYS241' (designed to block the interaction between tissue plasminogen activator & the NMDA receptor in the vascular compartment) for #Parkinsons lystherapeutics.com/2025/09/22/lys…
Combination therapies! All the cool kids are doing them. Clemastine & metformin show encouraging results in #MultipleSclerosis clinical study; "Positive proof of concept results" theguardian.com/society/2025/s…
A new study suggests that "rationally designed microbial consortia targeting neurometabolite production can modulate brain physiology & confer neuroprotection" in a female fly model of #Parkinsons nature.com/articles/s4152…
New research from @MerkTimon @neumann_wj & collaborators demonstrate the use of brain signal decoding for neuromodulation covering key innovation domains for neurotech. across >123 h of brain signals from 70 patients who had treatment with brain implants nature.com/articles/s4155…
New research finds "Leukotriene receptor antagonist treatment was not associated with an altered risk of #Parkinsons among people aged 50–84 years with asthma but was linked to a higher incidence of neuropsychiatric events" academic.oup.com/braincomms/art…
New research from @luis_bonetponce & colleagues identifies new players involved in LYsosomal Tubulation/sorting driven by LRRK2 (LYTL); RILPL1 is recruited to dysfunctional lysosomes in an LRRK2 kinase activity–dependent manner, facilitated by pRAB rupress.org/jcb/article/22…
The Science of Parkinson's retweeted
Luis Bonet-Ponce, Mark R. Cookson et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. hubs.la/Q03KN2Fg0 #Organelles #lysosomes #Trafficking
New research from @andrea_sturchio @PerSvenningsson & colleagues report that high cerebrospinal fluid DOPA decarboxylase levels predict cognitive decline in #Parkinsons patients - potential biomarker? …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…
Interesting: @EleTerrabuio @G_ConstantinLab et al report that CD8+ T cells are dysregulated in #Alzheimers & in 3xTg-AD mice, resulting in activated CD103– tissue-resident memory T cells & large amounts of granzyme K; Removal=reduced pathology in 3xTg mice nature.com/articles/s4146…
Exciting news for the Huntington's disease community: UniQure @uniQure_NV announce positive (read: remarkable!) Phase 1/2 clinical trial results for their gene therapy product AMT-130 (which encodes a microRNA to reduce levels of Htt protein) uniqure.com/investors-medi…
One for the diary: Agnete Kirkeby @Kirkeby_Lab will be speaking at the @EdinburghParki2 Edinburgh #Parkinsons 2025 lecture, discussing where we are with stem cell therapies for Parkinson’s edinburghparkinsons.org/edinburgh-park…
Michael Okun @MichaelOkun
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Jonny Acheson @jonny_acheson
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Kailash Bhatia, @kailashbhatia
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Gavin Mogan @purposeful_pd
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Bas Bloem @basbloem
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K Ray Chaudhuri @KRayChaudhuri1
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Patrik Brundin MD PhD @BrundinPatrik
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Matt Eagles ⚒️ @MattEagles
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Indu Subramanian @DrISubramanian
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RAUL CUAUHTEMOC BAPTI... @rcbaptistarosas
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Brain @Brain1878
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Bas Bloem @basbloem
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David Breen @breenneurology
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