The Science of Parkinson's @ScienceofPD
Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂 scienceofparkinsons.com London, England Joined January 2016-
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New perspective from @andreashorn_ & @neumann_wj on adaptive circuit targeting, a unified framework that combines adaptive DBS & connectomic DBS, decodes symptom severity from brain signals & adaptively activates the most relevant symptom-response circuits nature.com/articles/s4158…
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In a new report from @touteiro & colleagues report a novel SNCA missense variant (c.174G>C; p.K58N) in a #Parkinsons patient & provide a detailed description of its clinical phenotype & molecular effects …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…
Results of the PhotoPharmics trial (NCT02175472) assessing daily light therapy (with a circadian effective targeted spectrum of light) reports the treatment was safe in 92 people with #Parkinsons & showed improvement in both motor & non-motor MDS-UPDRS neurotherapeuticsjournal.org/article/S1878-…
New paper reports that artemisinin mediates neuroprotection in a rodent model of #Parkinsons (via regulation of Adcy5-Gch1-BH4 axis); Artemisinin binds directly to Adcy5, increases Gch1 expressions & BH4 production; Suppression of Adcy5⬇️midbrain dopamine genomebiology.biomedcentral.com/articles/10.11…
Gain Therapeutics @GainThera announces that it has received Australian approval of a 9-month extension for its Phase 1b dosing study of of GT-022887 (GCase modulator for #Parkinsons) & reports positive independent data monitoring committee recommendation gaintherapeutics.com/newsroom/press…
New research from @teanijarv @OskarHansson9 & colleagues that tau asymmetry (observed in #Alzheimers) is not associated with a weaker inter-hemispheric connectivity, but might reflect hemispheric differences in vulnerability to Aβ pathology nature.com/articles/s4146…
The Science of Parkinson's retweeted
I am very excited to let you know that my first PhD study has now been published in Nature Communications. 🧠📄 See the link to the article or read a summary in the post below! ⬇️ #alzheimersdisease #tau #amyloidbeta #neuroimaging #MRI #PET
I am very excited to let you know that my first PhD study has now been published in Nature Communications. 🧠📄 See the link to the article or read a summary in the post below! ⬇️ #alzheimersdisease #tau #amyloidbeta #neuroimaging #MRI #PET
A pilot case–controlled study from @OACerebro & colleagues find elevated mean corpuscular hemoglobin concentration could be a potential peripheral biomarker of #Parkinsons in a Mexican cohort (70 PD & 122 controls) mdpi.com/2076-3425/15/9…
New paper from @Ayan_2809 @pfeffersuzanne & colleagues indicates that Golgi associated Rab proteins contribute to the localization of PPM1H & non-phosphorylated Rabs regulate PPM1H phosphatase activity via an allosteric site - new target for #Parkinsons? jbc.org/article/S0021-…
Results of ENLITE-PD (NCT04291014, 16-week, randomized, phase 2, sham-controlled trial to select the superior bright white light therapy frequency (based on change in PDSS-2), & safety in 150 people with #Parkinsons) did not meet the criteria for advancing …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…
In addition to the well-known neuroprotective role of GDNF/GFRα1/RET signaling, a new paper finds "a physiological requirement of the GFRα1 component of this neurotrophic system for the continuous maintenance of SN dopaminergic neurons in the adult brain" journals.plos.org/plosone/articl…
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