JCellBiol @JCellBiol
The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress jcb.org New York, NY Joined September 2009-
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New news! Our latest (preprintless) story on MVB maturation taking place on a subset of septin-coated microtubules. Ben Robinson's PhD thesis and the last opus from my 15-year Drexel residency. A tweetorial to follow.
New news! Our latest (preprintless) story on MVB maturation taking place on a subset of septin-coated microtubules. Ben Robinson's PhD thesis and the last opus from my 15-year Drexel residency. A tweetorial to follow.
Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule-associated #septins, which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from @SeptinLab @drexel_coas @UVa_CellBio: hubs.la/Q02v9FQ30
Viewpoint: Campanella and Kannan @QMUL discuss the emerging knowledge of the molecular composition and function of mitochondrial–nuclear contact sites in eukaryotes, including recent work by @JanaOvciarikova @SheinerLab et al. (hubs.la/Q02v9q590): hubs.la/Q02v9mBl0
Ward, Vangala, Kamber Kaya, Radhakrishnan et al @VCU show that in addition to its role as a positive regulator of #proteasome genes, the transcription factor Nrf1/NFE2L1 can also induce #autophagy–lysosomal pathway genes & drive autophagic flux hubs.la/Q02tZ1CK0
Wang, Lu et al. @CincyChildrens demonstrate the critical role of BRG1/SMARCA4 for #oligodendrocyte precursor cell differentiation and remyelination hubs.la/Q02tPfbS0
We are extremely happy to see our work published in @JCellBiol where we show how #UBAP2L promotes assembly and stability of nuclear pore complexes #NPCs during interphase. Thank you to @YongrongL and all authors and reviewers for an amazing job! 🙏🥳🤩 rupress.org/jcb/article/22…
.@YongrongL et al. @SumaraLab @IGBMC show how UBAP2L facilitates assembly and stability of mature NPCs at the nuclear envelope during early interphase to ensure efficient nuclear transport, adaptation to nutrient stress, & cellular proliferative capacity hubs.la/Q02tP01h0
Spotlight: Antonio Galindo @MRC_LMB highlights new results from Assaad, Wiese, and colleagues (hubs.la/Q02tNDbj0) showing how the TRAPPII complex orchestrates growth decisions when resources are limiting. hubs.la/Q02tNCmS0 #PlantBiology #Trafficking
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic #StemCells. A new study from Yung-Li Chen, Andreas Ettinger, Maria-Elena Torres-Padilla (@METorresPadilla) et al @HelmholtzMunich: hubs.la/Q02t0S800 #CellDivision #centromeres
OMA1 clears traffic jam in TOM tunnel in mammals. Shiori Sekine and Yusuke Sekine @AgingPitt discuss the work by Krakowczyk et al. (hubs.la/Q02sSPX90) in Spotlight ➡️ hubs.la/Q02sSKgC0 #Organelles #mitochondria
Yiyang Han and Li Yu @Tsinghua_Uni reveal how calcium regulates migrasome formation and propose a sequential interaction model involving Syt1 and Tetraspanins in the formation and stabilization of #migrasomes. hubs.la/Q02tCcjV0 #migration #motility #membrane #lipid
Model of Caspase-1 mediated HFSC homing to the epidermis upon wounding. From Hegde, Ghosh et al. @Jamora_lab @DBT_inStem uncovering that extracellular Caspase-1 induces hair stem cell #migration in wounded and inflamed skin conditions hubs.la/Q02s94ry0 #StemCells
Behind every thorough #PeerReview is a collaborative effort. @RockUPress journals encourage co-reviewing manuscripts w/ trainees (#gradstudents & #postdocs) and recognize the invaluable contributions of co-reviewers. Learn more about our initiative: hubs.la/Q02qzgHy0
Image shows fragile X–related (FXR) family proteins promote viral replication. From Li et al. showing that liquid–liquid phase separation of FXR proteins drives clustering of replication organelles of #SARSCoV2. hubs.la/Q02s92vk0 #COVID19 #Virology #Organelles
Image: other proteins implicated in IRE1α activation have structural motifs similar to A1 segment of cholera toxin (CTxA1). Simpson et al. @BostonChildrens show that IRE1α recognizes a structural motif in CTx to activate an unfolded protein response hubs.la/Q02rZvm_0
Image shows multiplex staining of phosphoinositides across scales, using recombinant biosensors for the multiplex and super-resolution detection of phosphoinositides, developed by @hannes_maib @Fran_Bottanelli, @petiaadarska, @struttlab and colleagues: hubs.la/Q02rZvyd0
Robinson et al. @Cambridge_Uni investigate the role of the AP-1 adaptor complex in outgoing and incoming membrane traffic. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes. hubs.la/Q02rZfx_0
Image shows BUB-3 recognition of pMELT motifs drives the rapid increase in BUB-1–BUB-3 localization at kinetochores during mitotic entry. From Houston, Kim, @Protofilament @oegemadesai_lab and colleagues: hubs.la/Q02rZdtJ0 #CellCycle #CellDivision #Genetics #Biochemistry
Physiological Faa1 membrane localization is required for efficient #lipid incorporation and maintenance of autophagic flux. From Baumann, Achleitner, @susanna_tulli, @martens_sascha et al. dissecting Faa1 function and recruitment during #autophagy hubs.la/Q02rQDVY0
At @RockUPress, we value the collaborative efforts behind #PeerReview. So we implemented a process allowing invited reviewers to formally acknowledge their co-reviewers’ efforts. Take advantage of our Co-Reviewer Recognition initiative: hubs.la/Q02qzgK50
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Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule-associated #septins, which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from @SeptinLab @drexel_coas @UVa_CellBio: hubs.la/Q02v9FQ30
Congrats to first-authors Sonja Achleitner, Verena Baumann, and @susanna_tulli (@martens_sascha lab) on their recently published paper in @JCellBiol 🥳 Their study shows that Faa1 is crucial for autophagosome formation and autophagosome maintenance 💡 Watch their #SuccessStory ➡️
Manuscript accepted and @JCellBiol for the turnaround time win. Time from submission, review, resubmission, re-review, acceptance: 82 days! Just in time for @WormGuyKade to start his postdoc with @maxwellheiman
We are extremely happy to see our work published in @JCellBiol where we show how #UBAP2L promotes assembly and stability of nuclear pore complexes #NPCs during interphase. Thank you to @YongrongL and all authors and reviewers for an amazing job! 🙏🥳🤩 rupress.org/jcb/article/22…
📢 #PaperAlert Congratulations to #HelmholtzMunich expert Prof. Maria-Elena Torres-Padilla @JCellBiol👇
Chen, @METorresPadilla et al. @HelmholtzMunich investigate how the correct balance of centromeric transcripts from mouse stem cells affects #chromatin recruitment of CENPC & propose a model where structural RNA features are key for RNA–protein interactions hubs.la/Q02t0Jnf0
Interesting.
The cadherin–catenin linkage has been considered the keystone of junctional force transmission, but new findings challenge this paradigm. Sebbagh @univamu and Schwartz @YaleMed discuss new research in this Viewpoint: hubs.la/Q02rw8QM0
Thrilled to share that our paper showing how tissues regulate #proteasome content in vivo is now accepted for publication @JCellBiol! Congratulations to our talented postdoc @JenniferGilda (now in Genentech) and PhD student @KDharanibalan for their remarkable work! #muscle 📷
My San Diego journey continues w a visit at UCSD 🥳 Meeting a few @JCellBiol board members and some of the many excellent scientists here!
A new study from the 🔬 @Jamora_lab uncovered a novel function of caspase-1, a protein classically known as an integral component of the cytosolic #inflammasome. Read about their findings in 📚 @JCellBiol! 👉 bit.ly/3JcrM8n
thrilled to share our latest review discussing presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses. hubs.la/Q02rGTT70
Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders. New review from Gui-Jing Xiong and Zu-Hang Sheng (@zuhangsheng) @NIH_NINDS: hubs.la/Q02rGQwY0 #Trafficking #Neuroscience
Phosphatidylserine externalization is a marker for PM damage. However, PS synthesis and trafficking are also important for PM repair, in part through prompting the assembly of Tspn4 rings to limit the size of the damage.
Image shows how phosphatidylserine facilitates Tspan4 accumulation at damage sites. From Li, Norris, @rob8yang et al. @UNSW demonstrating that the mobilization of phosphatidylserine to sites of membrane damage aids the assembly of tetraspanin rings. hubs.la/Q02qM0MC0
Congratulations...
Hegde, Ghosh et al. @Jamora_lab @DBT_inStem report that extracellular Caspase-1 functions as a chemotactic factor. They solve the question of the cue(s) that coax the migration of HFSCs into the epidermis in #woundhealing & inflammatory skin conditions. hubs.la/Q02s92fb0
Stain phosphoinositides in fixed cells and tissues: now in its final form in my favourite journal @JCellBiol ! Super proud of the first work from my independent lab and hope it will be useful to the community rupress.org/jcb/article/22… All plasmids here: addgene.org/Hannes_Maib/
👀
Logistics of defense: The contribution of endomembranes to plant innate immunity. New review from Deepak Bhandari (@Deepak_ddb) and Federica Brandizzi (@msubrandizzilab) @MSUDOEPlantLab @michiganstateu: hubs.la/Q02r8_YK0 #PlantBiology #Disease #Trafficking
何度もJCBよりポストいただきありがたし。 総説執筆を計画する際、着眼するテーマはもちろん、誰と一緒に書くかも大事な点。 ラボの若手と書いたり、研究スタイルを尊敬している研究者に共著依頼する、等々。 今回は後者。 自分もとても勉強になった。感謝。
Non-canonical ubiquitination and its biological relevance. From Akizuki, Kaypee, Ohtake, & @IkedaResearch reviewing the #ubiquitin system covering the basic principles and recent discoveries related to mechanisms, technologies, and biological importance. hubs.la/Q02qqHvS0
According to a new study in @JCellBiol, a mutated protein expressed in lysosomes may contribute to #ParkinsonsDisease. Learn more about this study co-authored by Dimitri Krainc, MD, PhD (@DimitriKrainc): news.feinberg.northwestern.edu/2024/03/11/mut… #MedTwitter #NeuroTwitter
Check out our latest paper in @JCellBiol on the mechanism of PCM scaffold assembly: rupress.org/jcb/article/22…
This week's selection of articles and #preprints on #proteostasis thanks to @Bims_BiomedNews -- biomed.news/bims-proteo/20… Highligth: @JCellBiol rupress.org/jcb/article-ab…
PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion. #AACR2024 #AACR24 rupress.org/jcb/article/22…
.@Dr_Dioxide14 et al @WarfelLab identify a new role for PIM1 as a critical regulator of #actin dynamics & #hypoxia-induced cell #migration. hubs.la/Q02ry-9l0 From our #Cancer Cell Biology collection: hubs.la/Q02rz3h_0 #AACR2024
Trends for United States
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