ChristosArgyropoulos MD, PhD FlozinatorInChief @ChristosArgyrop
Division Chief, Nephrology (im)personal views & account Division Chief, Nephrology UNMHSC (im)personal views #zerokale #nephrology #stats #covid19 is bad Land of Enchantment Joined September 2011-
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@ChristosArgyrop Yes but it's complicated: - Bonferroni is just guaranteeing a false positive rate on the marginal association, it does not enforce anything about causal mechanism. - When variants are correlated (LD), Bonferroni will be conservative (but this is what Pe'er 2008 tried to quantify)
arstechnica.com/information-te… I own a refurbished HP with the same processor. AVX2 capable, monster of L1/2/3 caches.
It has been decades since I received a book in a wrap. This was the last copy of this gem of a #perl book
Verdict is in about spirullina
🚨Hot off the Press. As suspected more than a month ago: H5 was detected at three [wastewater] plants located in a state with confirmed outbreaks of highly pathogenic avian influenza, H5N1 clade 2.3.4.4b, in dairy cattle, suggesting a large fraction of Influenza A virus inputs…
A few of my Prometheon themes. Not perfect yet because of all the luddite, anti-tech urine drinking numpties and the starry-eyed cybertruck driving heed contributing to the training dataset. A perfect illustration of Prometheon and his metaphor will take considerable effort.
Oh well
Dan Rather's quote this weekend about real news being what people in power don't want you to know is profound. And it applies to the secrecy by which the managed care industry runs U.S. health care --virtually unexplored by the mainstream media over the past 40 years.
Close to 40% of Asante speaking Ghanaians, Yoruba and Igbo speaking Nigerians have high risk APOL1 genotype. Let’s clear controversies and work on solving the problem @goKDIGO @OpeyemiOlabisi8 @meg21212 @kirkcampbell @SannaCherchiLab
This sentence in the interesting piece is very relevant to physician burnout: "She was ready to leave the executive track, and the position allowed her to put her medical training to good use without the daily grind of working in a clinic." propublica.org/article/cigna-…
We produce more fluff text FULL STOP. Contrast grant submission length, or your everyday contract length compared to the early 90s. The problem is more general and instead of addressing the root cause of fluff, we throw AI/LLM at it.
We produce more fluff text FULL STOP. Contrast grant submission length, or your everyday contract length compared to the early 90s. The problem is more general and instead of addressing the root cause of fluff, we throw AI/LLM at it.
One good thing Twitter has done for me is help me embrace typos 😅
also discussed on rounds today (below). @NephRodby educating and writing with a classic clever "click bait" title: Baby Poop Peritonitis
Sparsentan for FSGS in the DUET Open Label Extension: Long-Term Efficacy and Safety. 103 patients followed for median of 3.9 years. sciencedirect.com/science/articl…
You know, I never really understood how shutting down in-person dining at Applebees for a few months, four years ago, could do long term harm to society Until this. I had no idea.
@ChristosArgyrop @AnastasiaSMihai @mmamas1973 So do you prefer a pangolin burger or bat soup?
@ChristosArgyrop Also, credit to the LLM for figuring out that one of the men should have his hair in a bun.
Prevent the next pandemic ... #BBQ them both @AnastasiaSMihai @mmamas1973
Prevent the next pandemic ... #BBQ them both @AnastasiaSMihai @mmamas1973
Alex Meshkin, GED @alexmeshkin
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726 Followers 1K Following Hematologist @NovantHealth. Alumni @uoaofficial (MD), @PittTweet (PhD, IM/HemOnc) , @MDAndersonNews (BMT & CT). Fierce patient and environment advocate2: We still don’t have a complete understanding of population stratification, with many sub-threshold effects potentially overfitting to stratification [Aw et al. 2024]. The extent to which this impacts significant variants also remains unknown [Berg et al. 2019 eLife].
Ok, but this is twitter and we can't just talk about how great things have been. So here are four TRUTH BOMBS to absolutely DESTROY the GWAS die-hards out there (or at least lead to some interesting discussions instead of just rehashing the Bayesian/Frequentist food-fight).
@ChristosArgyrop Yes but it's complicated: - Bonferroni is just guaranteeing a false positive rate on the marginal association, it does not enforce anything about causal mechanism. - When variants are correlated (LD), Bonferroni will be conservative (but this is what Pe'er 2008 tried to quantify)
@zerohedge It’s okay we’re just supposed to talk about doing it not actually do it
@zerohedge What planet is she living on? $25T was good to go, but $35T is where she draws the line?
@ChristosArgyrop There are methods that do this [e.g. SLIDE: pubmed.ncbi.nlm.nih.gov/19381255/] but practically the Pe'er et al. estimates of "effective" tests were actually pretty accurate and so p<5e-8 stuck (even when testing 5M or 10M common SNPs where Bonferroni would be more conservative)
@ChristosArgyrop GLP1/Ozempic is one such example: BMI is a highly polygenic trait but target the *right* receptor and you can have massive effects.
@ChristosArgyrop - I do agree and it is absolutely plausible that one would need a much smaller number of causal variants to rescue/modify the phenotype if we knew the underlying mechanisms and interactions. GWAS only gets us effects marginalized across all the backgrounds.
TFW you’re white knuckled nervous worried the day before important news and a major new release… > over 400 new genome assemblies for the ATCC Genome Portal. > transitioning to Supporting Memberships > launch of a new NGS discrepancy tool for authenticated genomes…
@ChristosArgyrop Who said anything about plates? I was thinking more about decorative ponds. Anyway, I have a soft spot about bacteria that includes cyanobacteria.
@ChristosArgyrop Such a nice green though, so much better than kale green!
@ChristosArgyrop 🤣the challenges perfectly elucidated
@NephRodby @hswapnil @GrahamAbra @TWhittier_RUSH @ChristosArgyrop The grandpa s not tied up the diaper well - more than the diaper quality - 😊/ raises questions whether he needs a caregiver for performing PD too. In India, most PD s done by family/caregivers than independently by pt himself/herself
Nice paper from Adam Martiny (@UCI_OCEANS) and Stacey Saurez on cryptic intraspecies potential for #amr in E. coli journals.asm.org/doi/10.1128/sp… was really nice to see the #genomics data my team has been producing for the ATCC Genome Portal going to good use! 🙏🧬🦠🧫
@ChristosArgyrop At some point LLMs will become lacedemonian LMs, keep hope alive.
@TWhittier_RUSH @ChristosArgyrop @NephRodby Only one author on that one 🤣
Temporarily making an exception to my no-block policy given one particular troll who needs a time out.