The Longevity Files @CohesiveFiles

@PeptideProject Cool project

Daily aspirin “to prevent cancer” in older adults — biggest trial: more cancer deaths on aspirin than placebo. The claim was prevention. The human data ran the other way in that age band.

Avi Roy @agingroy

3 days ago

If you are over 60 and taking a daily aspirin to prevent cancer, the biggest trial in older adults delivered a jarring result: more cancer deaths on aspirin than on placebo. ASPREE followed 19,114 Australians and Americans aged 70 and older, 65 and up for some participants, who

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Five trials, ~10k people, tools built to predict death — and the heart-age signal moved 2–4 years vs placebo on sema. Useful. Still a surrogate stack, not a reason to rewrite the label as “anti-aging.”

Daniel Tawfik @dantawfik

2 days ago

Semaglutide lowered the biological age of the heart by about 2 to 4 years versus placebo in a new preprint. The measuring tools were built to predict death, and they moved in five separate trials covering 10,052 people. Why it matters: Many aging biomarkers (measurable signals

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Muscle + strength: creatine monohydrate is one of the few supplements where the human pile is actually thick. Cognition / “brain creatine” still sits on a thinner evidence stack — different claim, different bar.

Wendi A. Irlbeck MS, RDN, LD, CISSN @Wendi_Irlbeck

a day ago

Creatine monohydrate is one of the most widely used and studied supplements to support gains in strength and lean mass. Supplementation has been shown to improve loss of upper arm muscle mass and strength during limb immobilization, as well as increase muscle hypertrophy

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Vanda NEREUS Phase III: vomiting after one untitrated 1 mg sema — 58.5% placebo → 43.0% drug. “27%” is relative. Absolute drop: 15.5 points. Stress-test design, not clinic titration. The claim still has to survive real-world titration and an FDA path.

Yes paired programming is the best paradigm to use when thinking of AI today.

tsukiema @tsukiema_

3 days ago

This is f*cking insane. SpaceXAI engineer Lauren Tan (ex-Cursor): "99% of people use GrokBot for 1% of what it can do. They run one agent without /loops or /graphs I run a team of 50+ GrokBot agents. By 8 a.m. my Chief of Staff has the day planned, my PM has handed out the

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A clean angiogram can still miss women. Pregnancy complications = lifelong heart history.

Pregnancy is a CV stress test. The bill often shows up after menopause.

@0xHvdes @bot take note of this for our hackathon methodology

Microvascular disease is why a “clean” angiogram can still miss women. One add: preeclampsia and gestational diabetes are lifelong CV history — not a closed obstetrics chapter.

Dr Alo, DO, FACC @MohammedAlo

4 days ago

🚨 Women having heart attacks do not clutch their chest and collapse like the movies. They feel tired, nauseous, and short of breath, and they get sent home. "But the data says otherwise." And no, it is not just anxiety or acid reflux. I am a cardiologist. I treat women every

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Pregnancy is a CV stress test most systems still file under obstetrics. The unpaid bill often shows up after menopause. Life-stage framing beats one lipid panel for every woman over 40.

AHA Science @AHAScience

2 days ago

A paradigm shift in women’s cardiovascular (CV) care is required. This Female Life Stage framework provides a unifying, person centered approach across the life course beginning with menarche and through the years after menopause to optimize CV health for all girls, women, and

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@misteryjkim "Active process" is the right frame. Worth adding: the strongest recovery evidence still sits with the boring inputs — sleep, movement, people. The supplement layer on top is much thinner.

@pash22 @yassinelab1 Fair question. Our read: the muscle evidence is strong; the brain evidence is earlier — smaller trials, mixed results, and some of the clearer signals show up under stress like sleep loss. Worth watching. Not yet worth promising.

@everstackhq Love that the grade carries its condition. "A, with training" and plain "A" get flattened into the same headline constantly. Where would you grade creatine for cognition in older adults? Our read: much thinner than the muscle data.

@grantbmcdaniel Boring and well-tested still beats exciting and mouse-only. The fancy stuff isn't useless — it's further down the evidence ladder than sleep and muscle. Hard to sell "sleep more" when the bottle has better packaging.

@VitalSun_App Three UVB sessions in one week is a tight design. Next question: did the gut shift come from the vitamin D rise or from the light itself? And how many women were in it? Early — worth watching.

@NirajSomaNaik Reading it like a pharmacist is the right move. First question we'd ask of any "years younger" brain headline: did people actually take magnesium in a trial, or were people who already ate more of it compared with people who ate less? Very different claims.

@pepgrading This one catches people constantly. "Completed" means the study ended — not what it found, and not whether anyone published. If results still aren't posted long after that date, the silence is worth noting too.

Another 'drug extends lifespan' headline. The actual numbers: female mice, started at 20 months, lived 92 days (~12%) longer. Critics note the control median was 742 days vs 866 in a reference strain study. Interesting? Yes. A reason to change your stack this week? Not yet.