Everstack @everstackhq

Dr. Scott Kanoski on @hubermanlab: cut very sweet foods and they start tasting too sweet. A 2016 trial backs the taste shift, but a 180-person, 6-month trial found liking for sweets did not change. Both studies: everstackhealth.com/en/university/…

Andrew D. Huberman, Ph.D. @hubermanlab

6 days ago

Avoiding very sweet foods eventually makes them taste too sweet and reduces sugar cravings Dr Scott Kanowski on the Huberman Lab podcast out now.

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6/ Our take: test if you have a reason to run low, count every source toward the 4,000 IU adult upper limit, and retest after about 3 months at the same lab. Not medical advice. Limits, funding and DOIs: everstackhealth.com/en/science/vit…

5/ Daily beats big boluses. In a 25-trial analysis of immune outcomes, daily or weekly dosing helped and large one-off doses did not. People starting very low gained the most (Martineau 2017).

1/ Got a vitamin D result and not sure what it means? We read the guidelines and dose trials. The short version: under 30 nmol/L (12 ng/mL) is a deficiency risk, 50 nmol/L (20 ng/mL) or more is adequate for most people, and higher is not clearly better.

@bryan_johnson raises a fair point: DEXA counts water as lean mass, so short creatine trials can overstate muscle. The strength data still hold across many RCTs. Both sides, cited: everstackhealth.com/en/science/cre…

Bryan Johnson @bryan_johnson

2 weeks ago

Creatine didn't build muscle or burn fat in this study. It was water retention. Exercise wasn't randomized. Participants chose whether to train. DEXA scans count water as "lean mass". Creatine hydrated muscle cells. It didn't synthesize new contractile fibers. The drop in

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6/ Full summary with every DOI: everstackhealth.com/en/science/que… Waitlist (no payment today): everstackhealth.com/en/products/qu…

5/ Interactions we list on the page: warfarin (case report), P-gp/fexofenadine (+55% exposure), CYP3A4 lab inhibition, quinolones (gyrase binding in lab). Ask a pharmacist if you take prescription drugs.

1/ We published a plain-English research summary on quercetin and inflammatory markers. Grade C. Our claim is structure/function only: supports a healthy inflammatory response. It is not meant to diagnose or treat any condition.

Big observational signal from @foundmyfitness: heavier coffee drinkers carried less visceral fat and more lean mass. Observational, so it shows association, not cause. Our cited visceral fat explainer covers what trials show actually moves it: everstackhealth.com/en/university/…

Dr. Rhonda Patrick @foundmyfitness

3 weeks ago

People who drank more coffee had less body fat, less visceral fat, and more lean mass than less-frequent or non-drinkers. The biggest benefit was seen at 5 or more cups per day. And for men, every extra cup per day was associated with a ~10 ng/dL higher total testosterone.

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Read it, including limits and what it does not mean: everstackhealth.com/en/science/ber… Sources include Dong 2012, Lan 2015, Lee 2006, Yin 2008, Guo 2012 (DOIs on the page). 2/2

We published a plain-English research summary on berberine and glucose metabolism. Grade C, on purpose: meta-analyses show a metabolic signal, but most trials were small and low quality. Drug-interaction risk is real (CYP enzymes). 1/2

@foundmyfitness The dose comparison is the most useful part: one cup improved FMD where half a cup or placebo did not. The gain came from adults with metabolic syndrome over six months, so it is a signal for that group, not yet proof for healthy adults.

@davidasinclair Worth reading the HRT part closely: the paper says the step at the final period looks markedly attenuated in women on hormone therapy. That is an association in cross-sectional lab data, not a trial showing delayed change.