Hypha Discovery @HyphaD
We support pharmaceutical and agrochemical companies worldwide through the production and purification of metabolites and API impurities. hyphadiscovery.com United Kingdom Joined August 2018-
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Suzetrigine is the first non-opioid painkiller to the market in 20 years. We take a quick look at what's published so far about the metabolism of suzetrigine, where a major active metabolite is reported. Read more at hyphadiscovery.com/blog/cyp3a-med…
Check out this paper by the “Translatability of MetID In Vitro Systems Working Group” summarising commonly used in vitro MetID practices in pharma companies, and crucially how effective they are at predicting circulating human metabolites. hyphadiscovery.com/paper-picks/th…
One more PhD studentship through @MIBTP_BBSRC in collaboration with @CorreLabo and @HyphaD as industrial partner. An exciting project aiming to discover biocatalysts from fungi that can be used for the biotransformation of drugs. 🍄🧬💊 Please RT shorturl.at/uAnQC
Major biotransformation routes of Cytokinetics' aficamten involve hydroxylation, onwards glucuronidation and gut metabolism, and is the subject of our latest blog article. Find out interesting aspects of aficamten's metabolism at hyphadiscovery.com/blog/major-bio…
Some recent papers have prompted us to look at the critical role of NMR spectroscopy in ADME studies. hyphadiscovery.com/blog/nmr-an-in…
organic-chemistry.org/info/presentat… (sponsored) Hypha Discovery is a specialist CRO supporting pharmaceutical and agrochemical companies worldwide through the production, purification and identification of metabolites and late-stage derivatives of drugs in discovery and development.
In this open access review in Drug Discovery Today we look at why, when and how metabolites of small-molecule drugs are synthesised from the perspective of a specialist CRO. hyphadiscovery.com/publication/sm… #drugmetabolism #drugdevelopment
In our latest blog article we take a look at the growing knowledge around metabolism of targeted protein degrader drugs such as PROTACs. hyphadiscovery.com/blog/metabolis… #degraders #protacs #drugmetabolism
In part 2 of our delve into the metabolism of small molecules approved by the FDA in 2023, we focus on drugs where metabolism in humans results in glucuronides and other conjugates. hyphadiscovery.com/blog/metabolis… #drugmetabolism #medicinalchemistry #drugdiscovery #drugdevelopment
Part 1 of our blog on metabolism of small molecule drugs approved by the FDA in 2023 highlights drugs where active metabolites are involved. hyphadiscovery.com/blog/metabolis…
Interested in when and how to access metabolites? Join us for a 30 minute webinar on Thursday 7th March to learn more. Register at hyphadiscovery.com/event/synthesi…
Read our latest blog on why N-glucuronidation of drugs is important in human drug metabolism. hyphadiscovery.com/blog/n-glucuro… #drugmetabolism #medicinalchemistry #drugdiscovery #drugdevelopment
Just in time for #AMR awareness week, the 1st paper from Open Source Antibiotics @OSantibiotics pubs.acs.org/doi/10.1021/ac… #WAAW23 Great team effort including @School_Pharmacy @UNCPharmacy @MIPS_Australia @HyphaD @DNDi @WuXi_AppTec @Northeastern and a citizen scientist (hi Anthony!)
Are there easy ways to make metabolites of macrocycles? Here's one example illustrating the route we took to accessing metabolites of rezafungin. More at hyphadiscovery.com/poster/synthes… #drugdiscovery #macrocycles #drugmetabolites
Curious about metabolism of "beyond the Rule of 5" molecules such as macrocycles? In this blog we delve into the metabolism of some de novo-designed macrocyclic drugs approved by the FDA. hyphadiscovery.com/blog/metabolis… #drugdiscovery #medicinalchemistry #drugmetabolism
Using fluorine to improve metabolic stability? Here we look at motifs of some fluorine containing drugs liable to metabolism mediated defluorination, together with strategies used to mitigating the risk. See hyphadiscovery.com/blog/breaking-… #drugdiscovery #fluorine #medicinalchemistry
If you enjoyed part 1 of our blog on metabolism of 2022 FDA approved small molecule drugs, you'll hopefully like this follow-on looking at those drugs cleared by not just CYP3A4. Read part 2 at hyphadiscovery.com/blog/metabolis…
We need another Purification Chemist at Hypha. Come join us and learn from the best! hyphadiscovery.com/news/purificat…
Five membered nitrogen containing aromatic heterocycles are commonly used in medicinal chemistry. In our blog this month we look at the trends in metabolism of these ring systems. Read the blog at hyphadiscovery.com/blog/metabolis… #medicinalchemistry #drugdesign #drugmetabolism
If you're following news on small molecule drugs approved by the FDA in 2022, you might be interested in our blog on metabolism of these drugs. In part 1 we look at the trends and dig into biotransformations of drugs cleared mainly by CYP3A4. hyphadiscovery.com/blog/metabolis…
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