Kobe Lab @Kobe_Lab_
KOBEMicrollography!Structural biology of infection and immunity lab at UQ Brisbane, Queensland Joined May 2022-
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I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.0…
Excited to see our Arabidopsis TIRome paper published in PNAS. Have a read here doi.org/10.1073/pnas.2…. We hope this is the start of tuning TIR domains 😎
Excited to be at #2025ISMPMI come see me at p16 Tuesday to hear more about TIR domains and an effector that inhibits flax TNLs
Great job at 3MT!!
Plant TIR domains are the coolest TIR domains! Privileged to be a part of this work, that is up on bioRxiv. biorxiv.org/content/10.110… @Kobe_Lab_
Excited to share our work in @PNASNews . We report the cryoEM structures of both TRIF and TRAM uncovering the molecular basis of TRIF-mediated TLR3 and TLR4 signalling pathways. pnas.org/doi/10.1073/pn…
It has been a roller coaster year for me after experiencing extreme happiness and loss. Today I’m starting as a new PI @ANUChemistry. Very grateful to all my extended academic family @BiologyANU and all past and current mentors. Looking forward to forge new networks and collabs!
This week we had the pleasure of hosting cryo-EM guru @OliBClarke who gave the @UQ_News cryo-EM community a fantastic cryo-EM data-processing workshop. Thank you Oli for sharing your tricks with us, @FarrahBlades for wrangling the Bunya supercomputer, and all who attended! 🔬
Had a blast the last couple of days learning how to use our brand new Oryx8 crystallisation robot from @DougInstruments! First robot for the lab and first Oryx8 in Australia! 💎 #gulbaliinstitute #charlessturtresearch
2024 @UQ_SCMB Structural Biology division retreat. Another fantastic three days of science, sun and fun!
And so it ends … 3 days of fantastic science and beautiful Freo weather #crystal35 #scanz. Thanks to everyone who joined us from Japan, Korea, India, South Africa, Singapore, UK and USA. And of course our amazing Australian and New Zealand structural science community!
All the rising stars of Crystal35 conference @Crystal_SCANZ 🎉💎🥳👏👍🥂 Congrats everyone
Exciting session at Crystal35 conference @Crystal_SCANZ with the “rising star awards” starting with @bj_charles @MonashBDI 🎉 congrats
Congratulations to @JackKClegg for the 2024 SCANZ Mathieson Medal! @RACInational @UQ_SCMB 🥳
Thank you #crystals35 @Crystal_SCANZ organisers for inviting me to present our @CMMUQ1 work on high-throughput small molecule & protein crystallisation, crystal imaging with Rock Imagers #MicroED Pipeline using Glacious @XUEY85 @JackKClegg @weixi_gu @Kobe_Lab_ @movingwhat @
We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & @IlyaOsterman
It’s my great honour to be an ARC Future Fellowship 2024 recipient. It’s been a dream start for me to establish my own group @ANUChemistry @ourANU. Thanks to @UQ_SCMB, @UQscience and @CMMUQ1 for supporting my application. We will continue to collaborating closely.
It’s my great honour to be an ARC Future Fellowship 2024 recipient. It’s been a dream start for me to establish my own group @ANUChemistry @ourANU. Thanks to @UQ_SCMB, @UQscience and @CMMUQ1 for supporting my application. We will continue to collaborating closely.
Yesterday we celebrated Michael’s nomination to the Research Culture Celebration @Cambridge_Uni. Thanks for making our lab such an enjoyable place to work and learn, Michael!
Full scholarship available for a curious PhD student to take on one of the most interesting topics in virology: how do capsid proteins assemble into particles with different geometries? Use native MS and cryo-EM with @buffalo_berger at UQ to find out! 🔗griffith.edu.au/research-study…

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