Colin Jackson @Jackson_Lab
Protein Engineering and Evolution. Views my own. jacksonlab.wordpress.com Joined August 2013-
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Colin Jackson retweeted
I’m crine bro 😭
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Colin Jackson retweeted
‘Protein evolution as a complex system’ – A new Comment discusses protein evolution in terms of complex systems theory and machine learning approaches to model the dynamics of protein evolution nature.com/articles/s4158…
Colin Jackson retweeted
Really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with a little help from #directedevolution to do #chemistry not known in nature (and not easily done by humans).
Really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with a little help from #directedevolution to do #chemistry not known in nature (and not easily done by humans).
Colin Jackson retweeted
Excited to share our new work—PhageMaP, a high-throughput platform for genome-wide knockout screening in diverse phages across multiple hosts. PhageMap reveals essential, non-essential and conditionally-essential genes, interactors with host anti-phage defenses & enables rational…
Colin Jackson retweeted
Applications for this position close tomorrow. Don't miss out!
Applications for this position close tomorrow. Don't miss out!
Colin Jackson retweeted
Stepping into Substack, starting with (baby) thoughts on LLMs & Scientists. Inspired by great work coming out of ICML, new endeavors like @FutureHouseSF, and self reflections on my use of LLMs. stephaniewankowicz.substack.com/p/llms-and-sci…
Colin Jackson retweeted
Our recent paper looking at history of flagellar motility now online in final form @ISMEJournal We looked at 10,000 species to map the diversity and history of the bacterial #flagellar motor across the tree of life. @UNSWBABS @UNSWScience academic.oup.com/ismej/article/…
Colin Jackson retweeted
RT please 🙌 Applications for a postdoctoral position in *Bioinformatics* in my lab are still open! Come and work with us @ARMI_Labs at the beautiful @cityofmelbourne Apply here careers.pageuppeople.com/513/cw/en/job/… Inquiries: [email protected]
Colin Jackson retweeted
Even I thought this was me😂
Even I thought this was me😂
Colin Jackson retweeted
We're very excited to reveal that we have been collaborating with the amazing team @nvidia to significantly accelerate Boltz-2 via new #cuEquivariance kernels and create Boltz-2 NIM for everyone to deploy! Just announced on stage at #GTCParis!
We're very excited to reveal that we have been collaborating with the amazing team @nvidia to significantly accelerate Boltz-2 via new #cuEquivariance kernels and create Boltz-2 NIM for everyone to deploy! Just announced on stage at #GTCParis!
Colin Jackson retweeted
New paper from the lab from @Sriramgarg. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-ar…
Colin Jackson retweeted
The discovery of CRYAB as the binding partner of TANGO2 highlights the importance of intermediate filaments in metabolism and mitochondrial function and reveals the molecular basis of TANGO2 deficiency disorder (TDD) nature.com/articles/s4146… #metabolism #mitochondria @NatureComms
Colin Jackson retweeted
The responses I'm most invested in are the genuinely curious ones that happen in the open, constructively asking the hard questions and wondering how to get involved. Here are some of my quick thoughts in response 👇
The responses I'm most invested in are the genuinely curious ones that happen in the open, constructively asking the hard questions and wondering how to get involved. Here are some of my quick thoughts in response 👇
Colin Jackson retweeted
Our new perspective paper, led by Sevan Gholipour and Dongkyu Lee, is out @BiochemistryACS. We discussed molecular evolution and origins of antibiotic resistance genes" It is interesting to think how ARG evolved against natural vs synthetic antibiotics. pubs.acs.org/doi/10.1021/ac…
Colin Jackson retweeted
We did something radical that shouldn’t feel radical: we stopped funding science built for journals so that we can reimagine scientific publishing. First at @ArcadiaScience. Now at @AsteraInstitute. More below.
Colin Jackson retweeted
Why make a cofactor when you can get it for free? Our work, led by @FabianMunder, shows that bacteria from 22 phyla use the high-affinity transporter PqqU to obtain the redox cofactor PQQ from the environment as an alternative to cofactor synthesis. science.org/doi/10.1126/sc…
Super cool paper
Colin Jackson retweeted
New preprint! We carried out the largest complementation and inhibition study for diverse homologs in a single protein family (DHFR) to date. Highlights thread follows... 1/n 🧵
New preprint! We carried out the largest complementation and inhibition study for diverse homologs in a single protein family (DHFR) to date. Highlights thread follows... 1/n 🧵
Colin Jackson retweeted
Did you know that MLMs/order-agnostic AR models can be viewed as diffusion/FM, enabling correct plug-and-play guidance on your favorite pre-trained models such as ProteinMPNN/ESM3, to incorporate experimental data or model-based priors? Includes experimental base editor demo.
Did you know that MLMs/order-agnostic AR models can be viewed as diffusion/FM, enabling correct plug-and-play guidance on your favorite pre-trained models such as ProteinMPNN/ESM3, to incorporate experimental data or model-based priors? Includes experimental base editor demo.
Colin Jackson retweeted
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…
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