Oliver Rackham @TheRackhamLab
Synthetic biologist engineering mitochondria, RNA and new gene editing systems. NHMRC Investigator and Professor @CurtinUni @CurtinMRI and @TheKids_AU perkins.org.au/person/oliver-… Perth, Western Australia Joined November 2017-
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Oliver Rackham retweeted
It takes two to TANGO2! TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder Many thanks to our team, collaborators and reviewers. rdcu.be/epI3p #metabolism
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Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia? Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable staff.curtin.edu.au/explore-career…
Oliver Rackham retweeted
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice! academic.oup.com/nar/article/do… #RNA #mitochondria #mtDNA
Destroyer turned protector - FASTKD4 uses it’s Vsr nuclease-like structure to protect the polyadenylated tail of the mitochondrial MT-ND3 mRNA academic.oup.com/nar/article/do… #RNA #mitochondria #mtDNA
Oliver Rackham retweeted
Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. biorxiv.org/content/10.110… Muscle mito nanotunnels 1/3🧵
Better CRISPR base editors! More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases. @ACSSynBio pubs.acs.org/doi/10.1021/ac…
Organelles within mammalian cells are surprisingly interconnected, and lipids play a critical role Check out: Interorganelle phospholipid communication, a house not so divided @Trends_Endo_Met to see more cell.com/trends/endocri… #metabolism #mitochondria #lipids #Golgi #ER
Oliver Rackham retweeted
Online Now: Interorganelle phospholipid communication, a house not so divided dlvr.it/T9GyHt #trends #endocrinology #metabolism
Illuminating mitochondrial translation through mouse models @hmg_journal academic.oup.com/hmg/article/33… #mitochondria #mtDNA
Oliver Rackham retweeted
Unique architectural features of mammalian mitochondrial protein synthesis dlvr.it/T854Mm
Oliver Rackham retweeted
Unique architectural features of mammalian mitochondrial protein synthesis 30-day free access to our new review at: authors.elsevier.com/a/1jE3u3QxxSux… Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.
High-fidelity Cas9 variants that prevent off-target cleavage typically reduce on-target activity. Adding TurboCas9 mutations to these enzymes can improve activity while maintaining off-target fidelity. @CellRepMethods cell.com/cell-reports-m…
Oliver Rackham retweeted
Mutational rescue of the activity of high-fidelity Cas9 enzymes dlvr.it/T5NxQL
Oliver Rackham retweeted
Are you tired of slow gene editing and scattershot targeting? Well no more, here we introduce HyperDriveCas9. An engineered Cas9 variant that is both hyperactive and hyper accurate. doi.org/10.1016/j.crme…
Oliver Rackham retweeted
💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics. rdcu.be/duKqS nature.com/articles/s4155…
Oliver Rackham retweeted
Quantitative volumetric analyses and morphological interactions supported by multi-omic profiling identify global organelle defects and mitochondrial dysfunction that can be rescued with ether lipids. nature.com/articles/s4155… #FIBSEM #3D #mitochondria #organelles #lipids
Check out this elegant News and Views @NatureCellBio by Antentor Hinton Jr @phdgprotein86 and Andrea Marshall @DrDreNeuroWay, highlighting the importance of organelle interconnectivity: nature.com/articles/s4155…
“I am a part of all that I have met” – Ulysses; Alfred Tennyson CRISPR screening, volumetric EM and multi-omics reveal the highly connected nature of organelles. Defects in peroxisomes, Golgi and the ER converge on mitochondria via the lipidome. nature.com/articles/s4155…
Oliver Rackham retweeted
A new report has found that medical research in WA: 🇦🇺Returns $2.61 to Aus for every $1 invested 💼Added 2,632 jobs to WA in 2021 💰Contributed $322.9m to WA economy in 2021 👏Thank you: @telethonkids @ear_science @PerkinsComms @PerronInstitute @LionsEyeInstAus @Resp_Health
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