Matthew Kirshner @MattyKirsh
Biotech builder @Ferment; Ex-@Ginkgo. Off-the-cuff takes on biotech, venture, & splitboarding . Bridging NY / MA / MT. not investment advice 🧬🏔️🦠 synbiomba.substack.com Read biotech hot takes → Joined September 2012-
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Some additional bullets from the call: - The ability to show (early, just trends) efficacy in patients that are so far advanced (50% non-amb) is important and differentiating from what is known about Skyclarys to date - They did mention that the patients in the OLE thus far…
Some additional bullets from the call: - The ability to show (early, just trends) efficacy in patients that are so far advanced (50% non-amb) is important and differentiating from what is known about Skyclarys to date - They did mention that the patients in the OLE thus far…
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$LRMR quick thoughts before the call: The good: - 10/10 hit the targeted 50% of healthy volunteer skin FXN levels and they were actually all well above the 8.2 pg/ug target (median 13.2 pg/ug). - The functional data is strong with mFARS at 1-year comparable with Skyclarys…
$LRMR quick thoughts before the call: The good: - 10/10 hit the targeted 50% of healthy volunteer skin FXN levels and they were actually all well above the 8.2 pg/ug target (median 13.2 pg/ug). - The functional data is strong with mFARS at 1-year comparable with Skyclarys…
Matthew Kirshner retweeted
That’ll be interesting
Matthew Kirshner retweeted
But none of this is true: outside of annual flu vaccines it’s closer to 30 immunizations, all or most tested in placebo-controlled trials. We’ve gone from immunizing kids vs 8 diseases when I was a resident in the 1980s, to 16, including 4 for bacterial meningitis, 2 for cancer
Matthew Kirshner retweeted
1990s - Cheese used to be made with rennet derived from newborn calves' stomachs after killing them. Now - Rennet is produced via microbial fermentation for cheese production. The future will happen regardless of your dumb political takes.
1990s - Cheese used to be made with rennet derived from newborn calves' stomachs after killing them. Now - Rennet is produced via microbial fermentation for cheese production. The future will happen regardless of your dumb political takes. https://t.co/edFR7Qv9kl
Some thoughts for biofin twitter on the $LRMR Ph2 OLE readout coming out any day now. The key outcome is whether they can show strong skin FXN concentrations since that is the surrogate endpoint the FDA has agreed to for a BLA in Q2 2026. I feel pretty good that this will hit,…
Reading the LB Pharma S-1 and believe I’m seeing that the Chairman and former CEO as well as the SVP of Finance have part of their comp structured as royalties on future sales of the main asset. I’ve never heard of this in biopharma before but kind’ve love it. Are there any…
Does the $CAPR CRL have any read-through to other acceelerated approval candidates for rare diseases ( $QURE $LRMR)? At the highest level, the clinical trial stages, sizes and use of surrogate endpoints* would seem to put them in a similar bucket as the $CAPR HOPE-2 + OLE data…
Matthew Kirshner retweeted
Calm. Cool. Collected. Named everyone else on his crew. Said “anyone else would have done the same,” and then saved close to 200 people. A truly humble professional and hero. I hope this man gets every good thing he deserves.
Matthew Kirshner retweeted
Job opportunity: SiPhox is looking for a Chief of Staff that is an ex-founder with solid fundraising experience or an ex-VC with a strong ops, technical, or clinical background. About SiPhox: YC, Khosla Ventures, and Intel Capital-backed startup empowering everyday people to…
Matthew Kirshner retweeted
Remember, the enemy laughed at the destruction the Islamic Regime caused to the Weizmann Institute. They try to end lives, we save lives.
Nothing tastes more like July 4th than an @UtzSnacks Crab Chip
Matthew Kirshner retweeted
We are rebuilding 💪 nature.com/articles/d4158…
Now’s your chance to be part of a business growing like gangbusters in Bozeman, MT. My brother-from-another-mother @ElliotMarcille is opening up his second Bozeman pickleball site and opening up another $200K for investment from the community. If you’re a pickleball fan or a…
Now’s your chance to be part of a business growing like gangbusters in Bozeman, MT. My brother-from-another-mother @ElliotMarcille is opening up his second Bozeman pickleball site and opening up another $200K for investment from the community. If you’re a pickleball fan or a…
Matthew Kirshner retweeted
Cool, cool. ICE now blowing up the door of an American citizen’s house, sending in troops like they’re storming Bin Laden’s compound over a traffic accident.
Jason Kelly @jrkelly
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L @houndcl
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