WithersLab @LabWithers

Lab of David Withers @unibirmingham. ILCs | Mucosal Immunity | Tumour Immunity England, United Kingdom Joined December 2019

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WithersLab @LabWithers

a year ago

Relocating the lab to the Oxford Centre for Immuno-oncology going really well. Such a great research environment. We have new positions available, including this post-doc position: jobs.ac.uk/job/DHZ362/pos… New address is: [email protected] - email to find out more

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WithersLab @LabWithers

a year ago

I am delighted to announce our recent Wellcome DA success with @ActonLab and @ClatworthyLab. Super exciting opportunity. If interested in joining our team as a post-doc please contact any of us for more info.

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WithersLab @LabWithers

2 years ago

Great to see these two papers come out together today: nature.com/articles/s4146… nature.com/articles/s4146… Has been such a great collaboration with many groups, particularly the Clatworthy Lab. Congratulations again Colin and Isaac @ColinYCLee @ClatworthyLab

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WithersLab @LabWithers

2 years ago

5 of 5 Key finding #3: Administration of IL15/IL-15ra caused distinct NK tumour resident state that maintained effector functions and appeared to enhance tumour control (Fig 6). Many thanks to all involved, particularly @IWD_Sci, @ColinYCLee, @ClatworthyLab

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WithersLab @LabWithers

2 years ago

4 of 5 Key finding #2: Validation of transcriptomic changes confirmed really rapid changes in NK cells after tumour entry: upregulation of distinct integrins (e.g. CD49a) and loss of key effector functions (e.g. production of CCL5, IFNg) occurs after only 24hrs. See Fig 2/3.

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WithersLab @LabWithers

2 years ago

3 of 5 Key finding #1: Using a combination of photoconversion and scRNA-seq, we show that conventional NK cells rapidly adapt their transcriptome following entry into the tumour, establishing a distinct tumour-retained/resident state in only 48-72 hrs. See Fig 1.

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WithersLab @LabWithers

2 years ago

2 of 5 Building on the approaches published last year (pubmed.ncbi.nlm.nih.gov/35472220/), here we have interrogated what happens to NK cells after tumor entry and for the first time provide a real-time map of their progression to a dysfunctional state.

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WithersLab @LabWithers

2 years ago

1 of 5. We are pleased to present our latest study using our dynamic tumour-labelling models: biorxiv.org/content/10.110…

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WithersLab @LabWithers

2 years ago

We have a post-doc position available focused on intestinal and cancer immunology. Ideal for PhD students soon to submit, who want to work with some cool in vivo models to better understand immune responses. Position advertised on BSI Jobs Board immunology.org/careers/bsi-jo…

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WithersLab @LabWithers

3 years ago

3 year Post-doctoral position in the Withers Lab at the University of Birmingham Details: edzz.fa.em3.oraclecloud.com/hcmUI/Candidat… For more information and/or informal discussions regarding the post, please contact: [email protected]

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DKFZ Immunology Infection and Cancer @DKFZImmunology

3 years ago

We are thrilled to announce the speaker of our next i3 @DKFZ seminar: on November 14th at 4 pm we'll have the honour to host Prof. David Withers from @unibirmingham who will talk about a novel strategy to track changes in TIL function upon migration into tumors. Save the date! 🗓️

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Zhi Li_Immunology @ZhiLiImmunology

3 years ago

Pleased to see our paper "Photoconvertible tumors to track T cell dynamics" with my former lab @LabWithers is featured in a special collection on Mechanisms & Models of Cancer @JExpMed @cshlmeetings See the special collection to accompany the meeting: bit.ly/3SMzRo8

Journal of Experimental Medicine @JExpMed

3 years ago

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Alex Riding @RidingAlex

3 years ago

So great to see this finally out!! Top team @ClatworthyLab @loudon_kevin @KelvinTuong @drbstewart @iScience_CP cell.com/iscience/fullt…

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Rebecca Drummond @theRAD_lab

3 years ago

Very excited to share our new work explaining how #antibiotics can lead to life-threatening fungal infections, out today in @cellhostmicrobe! A short thread on the main take-home messages... 1/10 @LionakisLab @jigarvdesai authors.elsevier.com/c/1f3s66t8JEjA…

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Colin Lee @ColinYCLee

3 years ago

Pleased to have my first publication with @ClatworthyLab out & hopefully many more to come! Read our work in @FrontImmunol here: frontiersin.org/article/10.338…

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Journal of Experimental Medicine @JExpMed

3 years ago

.@ZhiLiImmunology @KelvinTuong @IWD_Sci et al use photoconversion to temporally label tumor-infiltrating lymphocytes, revealing the continuous migration of TCF-1+ T cells btwn the tumor & draining lymphoid tissue bit.ly/3OBixjH @LabWithers @ClatworthyLab @Hepworth_Lab