MatthiasFellner @MFellnerLab

Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago. Joined April 2020

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MatthiasFellner @MFellnerLab

a year ago

Just out: Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Great collaborative effort between @otagoPharmacy @joel_tyndall , @otagoBiochemist and @otago Chemistry doi.org/10.1002/cmdc.2…

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MatthiasFellner @MFellnerLab

2 years ago

New @BiochemistryACS paper about one of my favorite enzymes ever - Structural, Spectroscopic, and Computational Insights of the Ethylene-Forming Enzyme. Collaboration between @MSU_BMB @michigantech and myself at @OtagoBiochemist doi.org/10.1021/acs.bi…

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MatthiasFellner @MFellnerLab

2 years ago

Structures just released rcsb.org/structure/8T87 rcsb.org/structure/8T88 determined in collaboration with @Stanford @mbogyo and my lab at @OtagoBiochemist - JACS paper on Probes for Specific Detection of Staph Infections doi.org/10.1021/jacs.3… @JeyunJo @TulsiUpadhyay5 +others

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Matthew Bogyo @mbogyo

2 years ago

Check out our latest covalent probes for imaging Staphylococcus aureus infections published @J_A_C_S. Great work from @JeyunJo and @TulsiUpadhyay5 and collaborators. pubs.acs.org/doi/full/10.10…

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Tulsi Upadhyay @TulsiUpadhyay5

2 years ago

Thrilled to share the news!! Thanks Matt @mbogyo, for giving this fantastic opportunity to work on this project. Enjoyed teaming up with @JeyunJo, @MFellnerLab and all our collaborators 🙌 Thanks @ec_woods, @NikkiPedowitz, @SijieWang5 for helping us with this project!!

Matthew Bogyo @mbogyo

2 years ago

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Jeyun Jo @JeyunJo

2 years ago

Exciting news from our recent research with @TulsiUpadhyay5 on oxadiazolone-based probes targeting FphE, a S. areus specific serine hydrolase. This is a result of great collaboration with @MFellnerLab, the Valdez lab, Joanna Jaworek-Korjakowska, and the team at @mbogyo lab.

Matthew Bogyo @mbogyo

2 years ago

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Matthew Bogyo @mbogyo

2 years ago

Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by ⁦@JeyunJo⁩ and ⁦@TulsiUpadhyay5⁩ developing an oxadiazolone based probe for the S aureus serine hydrolase FphE. biorxiv.org/content/10.110…

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MatthiasFellner @MFellnerLab

2 years ago

1. characterization of a highly conserved S. aureus serine hydrolase. pubs.acs.org/doi/10.1021/ac… @OtagoBiochemist (Annabel Walsh) OtagoChemistry (Sutherland, Tan) & international collaborators A. Bakker, @mariovdstelt, @NatMart_Chembio, @NadiaAftab18, S. Dela Ahator @ChristianSLentz

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MatthiasFellner @MFellnerLab

2 years ago

One week left to apply #postdoc #position in #biochemistry on #research into #peptide & #enzyme via #phage in ##infectiousdisease at #university @OtagoBiochemist in #NewZealand and #Shanghai #SIMM Details: otago.taleo.net/careersection/…

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MatthiasFellner @MFellnerLab

2 years ago

We are looking for a Postdoctoral Fellow to create peptide tools for the treatment & diagnosis of infectious diseases at the University of Otago & Shanghai Institute of Materia Medica. Funded by New Zealand Maurice Wilkins Centre Starting September Details otago.taleo.net/careersection/…

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MatthiasFellner @MFellnerLab

2 years ago

We are looking for an Assistant Research Fellow to create Staphylococcus aureus samples for metabolomics to identify the roles of serine hydrolases in biofilms (otago.ac.nz/biochemistry/n…) University of Otago, Dunedin, New Zealand. Starting in July Details: otago.taleo.net/careersection/…

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Otago Biochemistry @OtagoBiochemist

3 years ago

Bacterial biofilm therapeutics project wins Marsden Fund support ift.tt/Ylq0Vr9 A project investigating new ways to fight deadly bacterial biofilms has won a Marden Fast-Start fellowship for its lead researcher, Otago biochemist Dr Matthias Fellner. Matthias is seeki…

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Otago Biochemistry @OtagoBiochemist

3 years ago

Otago researchers set to tackle health issues with Career Development Awards ift.tt/ED3hxJa From a global health crisis to Aotearoa’s health inequity – University of Otago projects awarded Health Research Council funding will benefit those at home and around the world…

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Otago Biochemistry @OtagoBiochemist

3 years ago

$3.8 million to Otago researchers in Career Development Awards ift.tt/Zaz9o1D The Health Research Council has awarded 19 Otago researchers almost $3.8 million in Career Development Awards. These awards help launch research careers through a wide range of master’s and…

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Marsden Fund @MarsdenFund

3 years ago

Taputapu kē! Dr Matthias Fellner🧑‍🔬 @MFellnerLab @otagoBiochemist @otago has been awarded a #MarsdenFund Fast-Start to study how #staphylococcus aureus 🦠 use biofilms in antibiotic 💊 resistant bacteria #infection s🏥. #staph #AntibioticResistance royalsociety.org.nz/what-we-do/fun…

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Louise Bicknell @bicknell_l

4 years ago

Really excited to have our paper describing mutations in histone H4 now out - a fantastic collaboration with @GijsvanHaaften and lots of families around the world. Now investigating the mechanism thanks to @MarsdenFund support!

AJHG @AJHGNews

4 years ago

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Louise Bicknell @bicknell_l

4 years ago

@GijsvanHaaften @MarsdenFund Thanks also to @MacePeter for helping with the structural interpretations of these mutations within the nucleosome!

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MatthiasFellner @MFellnerLab

4 years ago

Newly discovered #Staphylococcus aureus serine hydrolase probe and drug targets pub.iapchem.org/ojs/index.php/… My latest review of ten S. aureus protein targets for probe & drug development. Looking forward to new advances @mbogyo @ChristianSLentz and myself @OtagoBiochemist.

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MatthiasFellner @MFellnerLab

4 years ago

Excited to share my latest paper in #JournalofLifeSciences on #Cesium binding in #protein #crystals based on work between @MSU_NatSci and @OtagoBiochemist doi.org/10.36069/JoLS/… Consider #caesium in your #crystallography experiments to improve #diffraction or solve #phases.

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MatthiasFellner @MFellnerLab

5 years ago

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity doi.org/10.1042/BCJ202… Our latest work hot off the press from @OtagoBiochemist. Thanks @parakra, KD, @ItamarKass, @gnljameson, SMW & @Liz_Ledgerwood