Zernicka-Goetz Lab @MZG_Lab

Mammalian Embryo and Stem Cell Group - resolves the puzzles in early mammalian life. Group news from @Cambridge_uni | @Caltech zernickagoetzlab.pdn.cam.ac.uk/research.html Cambridge, UK | Pasadena, USA Joined May 2016

Tweets

588
Followers

3K
Following

254
Likes

1K

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

PGCs form very efficiently in this model, in their natural niche, driven by BMP signaling from the extra-embryonic tissues that develop here. Check out our paper for detailed insights on how to establish this model in your lab and areas for improvement. #PGC

1 1 6 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

We also show how the formation of ourhiembryoid relies on the right concentrations of BMP, NODAL, and mTOR pathways, allowing us to track their dynamics in this human embryo model. #DevelopmentalBiology #CellSignaling

1 1 4 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

As a bonus, our protocol reveals that the SOX2 domain gradually starts to express amnion markers. We can now track this differentiation of the epiblast into the amnion through time-lapse movies, adding a dynamic view to the process. #TimeLapse #CellBiology

1 1 5 1K 1

Download Image

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

Our protocol shows that the efficiency and size of the embryo-like structures, or “hiembryoids,” depend on the initial number of cells seeded from each of the three types. The models develop a SOX2 epiblast-like central domain that opens up a lumen. #Science

1 1 11 2K 0

Download Image

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

@_carlosgantner_ @BailWeatherbee @wellcometrust @PDN_Cambridge @Cambridge_Uni @SidneySussex If you have any questions or need guidance on setting up this model in your lab, feel free to reach out. We’re happy to help and provide advice.

0 1 6 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

Special thanks to the first author- wonderful & generous @_carlosgantner_ for leading putting our efforts here together; to @BailWeatherbee and Yuntao Wang for help; generous funders @wellcometrust & as always supporting @PDN_Cambridge @Cambridge_Uni @SidneySussex

1 1 8 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

I’ve been presenting our human stem cell embryo model, derived from programmed human ESCs, at conferences for a few years and last year, we finally published it. Now we’re excited to share a detailed protocol how to create these models #StemCellResearch nature.com/articles/s4159…

3 14 106 8K 26

Zernicka-Goetz Lab @MZG_Lab

a year ago

Very exciting paper!!! Congratulations!!!

nature @Nature

a year ago

Very exciting paper!!! Congratulations!!!

6 53 184 30K 35

0 0 10 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

6. I’m deeply grateful for my incredible students, post-docs and collaborators, whose enthusiasm, spark, and brilliance keep driving us forward. They remind me daily why I love this work. They push the boundaries of what’s possible. #Gratitude

2 2 10 2K 1

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

4. Thanks to advances in single-cell RNA sequencing and proteomics, we’ve propelled our research forward. It’s an exciting era as other groups are now also validating these early asymmetries as real and impactful.

1 2 10 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

5. 👩‍🔬Enter Lisa, our fearless PhD student who, despite the controversy, tackled the problem head-on with single-cell proteomics in collaboration with Aleks & Nikolai @slavov_n . Their unwavering determination was key to advancing this challenging work. #WomenInSTEM #PhDSuperstars

1 4 15 2K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

3. The pushback was intense; comments at conferences were often harsh. But we didn’t give up. It took a decade of persistence and new technologies to reveal the mechanisms behind these early asymmetries. #ResilienceInScience

2 2 14 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

2. Our early findings suggested that the first cellular differences in the mammalian embryo arise much sooner than expected—defying the established dogma. As a young group leader and woman, facing fierce criticism wasn’t easy but fueled us to test each step, hundreds of times.

1 2 12 1K 0

Zernicka-Goetz Lab @MZG_Lab

a year ago

LSE is incredible so apply for a JEDI to help you with your first or even second paper or grant - don’t miss this remarkable opportunity.

0 0 2 1K 0

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

1. One of my favorite lab projects: uncovering when and how cells begin to differ from each other as they first form. A long journey of discovery that dared to challenge the norms of the field. #StemCellResearch

3 11 79 17K 19

Magdalena Zernicka-Goetz @ZernickaGoetz

a year ago

Listening to @doristsao & @seanmcarroll while swimming was a pure treat for my birthday. This conversation reminds me of conversations with my father - the same deep passion for consciousness and how the brain shapes who we are. I miss you Doris @Caltech

3 1 22 4K 4

Adiyant Lamba @AdiyantL

a year ago

Our paper attempts to link different ideas into one model for the first cell fate decision, although unanswered questions still remain! This is a topic of long-standing interest in the @MZG_Lab, and you can read our review on the field here: pubmed.ncbi.nlm.nih.gov/37100517/

1 1 8 1K 1

Harmit S. Malik @HarmitMalik

a year ago

What I don't get about academia is the chronic lack of celebration. It is hard to get & maintain grant funding, hard to get papers accepted without Faustian bargains, hard to be a great mentor, & hard to maximize trainee success. All of it is hard. We should celebrate everything.

50 207 2K 120K 58

Dr Karen Mitchell PhD @karenmitchell__

a year ago

Narcissists/psychopaths/predators have an extreme sense of ENTITLEMENT. Fairness is not important to them. They will find loopholes to get what they want. They will break laws, rules, agreements to have what they believe is rightfully theirs. If they disadvantage or hurt…