Masahiro Ono @ Tocky Lab @MonoTockyLab
Immunologist | Creator and Developer of Tocky | Integrative Experimental and Computational Immunology | T cells | Cancer Imperial College London monotockylab.github.io London, UK Joined April 2013-
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Honoured that our T-cell immunotherapy research is featured in The Telegraph via Cancer Research UK. Using Tocky, we reveal the behaviour of therapy-responsive and anti-cancer T cells, aiming to further improve immunotherapy approaches to melanoma. telegraph.co.uk/science/cancer…
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🚀 Thrilled to share our new paper using Deep Learning and Tocky! nature.com/articles/s4146… 👉 We build on our original Tocky method by integrating CRISPR & deep learning to decode transcriptional dynamics. 🔥 7 years of work - toward data-driven immunology!
Masahiro Ono @ Tocky Lab retweeted
🚀Thrilled to announce our new Tocky-CRISPR-Deep Learning paper! ✅ConvNet + Grad-CAM decodes fluorescent timer (Tocky) data ✅Enables single-cell identification of enhancer-dependent Foxp3 transcription dynamics nature.com/articles/s4146… 🔥A step toward data-driven immunology!
🚀 New paper out! Our ConvNet + Grad-CAM approach decodes Fluorescent Timer (Tocky) data at single-cell resolution. Using Foxp3 Tocky, we reveal CNS2-controlled and developmental transcriptional dynamics. Built on 7 years of work with AI and CRISPR! nature.com/articles/s4146…
Masahiro Ono @ Tocky Lab retweeted
Bored of black-box UMAP and clustering in #Cytometry? GatingTree skips such methods, directly analyses high-dimensional data, builds reproducible tree paths across markers, and reveals group-specific effects. No dimensionality reduction, just interpretable gates. 🌳
Masahiro Ono @ Tocky Lab retweeted
🚀 Our next-generation cytometry tool GatingTree now published in #CytometryPartA! 🔗 onlinelibrary.wiley.com/doi/10.1002/cy… GatingTree enables systematic analysis of high-dimensional flow cytometry data, without relying on dimensionality reduction. 💻
Masahiro Ono @ Tocky Lab retweeted
Dr. @masahirono (@imperialcollege, UK), together with Dr. Nobuko Irie, Dr. Naoki Takeda, @Sato_Y_Lab, and Prof. Kimi Araki, has unveiled a machine learning-powered method to decode transcriptional dynamics using a Fluorescent Timer system. @NatureComms, doi.org/10.1038/s41467…
Masahiro Ono @ Tocky Lab retweeted
Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @Tolga_Bzkrt and @JiorgosKourelis labs: jobs.ac.uk/job/DNV032/res…
Excellent work from my long-term collaborator of over 17 years, @Sato_Y_Lab 🔬 on Runx/HTLV-1! The start of our collaboration goes back to my own Runx paper in 2007: nature.com/articles/natur… This Runx/HTLV-1 study is the latest milestone 🔬. Honoured to be a co-author 📄✨
Excellent work from my long-term collaborator of over 17 years, @Sato_Y_Lab 🔬 on Runx/HTLV-1! The start of our collaboration goes back to my own Runx paper in 2007: nature.com/articles/natur… This Runx/HTLV-1 study is the latest milestone 🔬. Honoured to be a co-author 📄✨
Masahiro Ono @ Tocky Lab retweeted
Out Now! Intragenic viral silencer element regulates HTLV-1 latency via RUNX complex recruitment bit.ly/4mfT8gb #HTLV1 #ViralSilencer #RUNX
Masahiro Ono @ Tocky Lab retweeted
What if Tregs are not a separate lineage, but part of spontaneously activated T cells? We integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity🧵(1/4) academic.oup.com/discovimmunolo…
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