Parallel Squared Technology Institute (PTI) @ParallelSqTech
PTI is a nonprofit focused research organization scaling proteomic technologies to explore proteome biology. A member of the @SchmidtFutures & @Convergent_FROs. parallelsq.org Boston, MA, USA Joined February 2023-
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I am looking forward to ICSB next week. I will present: 1⃣ New technology from @ParallelSqTech: parallelsq.org/blog/proteomic… 2⃣ New biology from @slavovLab: biorxiv.org/content/10.110…
Protein abundance is regulated by many mechanisms. We quantified them across the single cells in a mammalian tissue: 1⃣ The results revealed simple rules ! 2⃣ They may alter how you interpret single-cell DNA(RNA)-sed data. ⚠️ See @_AndrewLeduc's 🧵 biorxiv.org/content/10.110…
Protein abundance is regulated by many mechanisms. We quantified them across the single cells in a mammalian tissue: 1⃣ The results revealed simple rules ! 2⃣ They may alter how you interpret single-cell DNA(RNA)-sed data. ⚠️ See @_AndrewLeduc's 🧵 biorxiv.org/content/10.110… https://t.co/xdRexfmfG6
@NikoMcCarty @ParallelSqTech @AsimovPress Staggering sample loading to fit more samples per mass spec run: biorxiv.org/content/10.110…
@NikoMcCarty @ParallelSqTech @AsimovPress Screening for more peptide barcodes: biorxiv.org/content/10.110…
A clear summary of our approach & progress towards scaling up (single-cell) proteomics.
A clear summary of our approach & progress towards scaling up (single-cell) proteomics.
I was super excited to learn from @NikoMcCarty's essay, "How to Scale Proteomics", that there's an FRO working on high-throughput single-cell proteomics (@ParallelSqTech), and even more excited to see the progress they've made in just 2 years via their preprints. So here's a…
PTI is growing and we are looking for more scientists to join our team! Neurodegenerative Disease Senior Scientist: bit.ly/4n35ND7 Computational Biologist: bit.ly/4gplQsJ Research Chemist: bit.ly/46n0Q13
We share our technologies to maximize the benefit for the community. PSMtags enable 9-plexDIA with better sequencing and multiplexing. PSMtags support sensitive proteomic analysis of over 1,000 samples / day. parallelsq.org/psmtags
Protein degradation is often considered as a final step in regulating gene expression. It also regulates the first step: Transcription Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥: ⬛️ It has a key advantage. 👇
Protein degradation is often considered as a final step in regulating gene expression. It also regulates the first step: Transcription Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥: ⬛️ It has a key advantage. 👇
The registration for SCP2026 is open ! Join us next July for the the 9th Single Cell Proteomics Conference. single-cell.net/proteomics/scp…
Scaling DNA sequencing is a notable success story. Scaling protein analysis is harder since the proteome is a much taller mountain: nature.com/articles/s4159… @AsimovPress writes about @ParallelSqTech's approach to scale up proteomics.
Increasing throughput is particularly helpful when it also increases data quality. 🚀
Increasing throughput is particularly helpful when it also increases data quality. 🚀
A succinct and clear presentation of multiplexing proteomic technologies that we developed at @ParallelSqTech.
A succinct and clear presentation of multiplexing proteomic technologies that we developed at @ParallelSqTech. https://t.co/V4lHih4SKr
PTI will be represented at #ASMS2025 with with two posters (TP203 and ThP 533) and two talks (TOA 2:30 pm and WOA 8:30 am). Find us to hear about our PSMtag, and applications in Alzheimer's and aging biology!
🟦 Label-free single-cell proteomics (blue bars). 🟧 Multiplexed single-cell proteomics affords higher throughput (orange bars). ⬛️Proteome depth & quantitative accuracy are comparable. We aim to make the 🟧 bars taller. parallelsq.org/psmtags biorxiv.org/content/10.110…
The next generation plexDIA tags are looking promising !
The next generation plexDIA tags are looking promising !
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