Jason Derks @_JasonDerks
Increasing throughput of proteomics @ParallelSqTech Boston, MA Joined December 2018-
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I’ll be attending iSCMS and presenting work from @ParallelSqTech. I look forward to sharing what we have been up to and learning from the community!
I’ll be attending iSCMS and presenting work from @ParallelSqTech. I look forward to sharing what we have been up to and learning from the community!
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Vimentin in Fibroblast cells is likely functionally analogous to Krt5 in Basal cells. It’s amazing that single cell proteomics can enable these types of finding. Check out the work from @_AndrewLeduc for more details!
Vimentin in Fibroblast cells is likely functionally analogous to Krt5 in Basal cells. It’s amazing that single cell proteomics can enable these types of finding. Check out the work from @_AndrewLeduc for more details! https://t.co/gkvEfxEc0l
Jason Derks retweeted
This work is the culmination of everything I have worked on since starting my PhD. 🧵
This work is the culmination of everything I have worked on since starting my PhD. 🧵
Jason Derks retweeted
I was super excited to learn from @NikoMcCarty's essay, "How to Scale Proteomics", that there's an FRO working on high-throughput single-cell proteomics (@ParallelSqTech), and even more excited to see the progress they've made in just 2 years via their preprints. So here's a…
Jason Derks retweeted
PTI will be represented at #ASMS2025 with with two posters (TP203 and ThP 533) and two talks (TOA 2:30 pm and WOA 8:30 am). Find us to hear about our PSMtag, and applications in Alzheimer's and aging biology!
Jason Derks retweeted
We just released JMod: an open source software supporting multiplexed DIA. It supports parallelization in both the mass domain (plexDIA) using small mass offsets and in the time domain (timePlex). It enabled 27-plex DIA & much further scaling 🚀 biorxiv.org/content/10.110…
We just released JMod: an open source software supporting multiplexed DIA. It supports parallelization in both the mass domain (plexDIA) using small mass offsets and in the time domain (timePlex). It enabled 27-plex DIA & much further scaling 🚀 biorxiv.org/content/10.110… https://t.co/b05SODOKui
Jason Derks retweeted
Our paper on the impact of protein leakage due to loss of membrane integrity for single cell proteomic sample prep is out in @NatureComms! We analyze thousands of primary single cells from murine tracheal tissue and record membrane permeability🧵 nature.com/articles/s4146…
Jason Derks retweeted
Protein samples can be multiplexed to increase throughput. In 2023, @ParallelSqTech set out to make tags (barcodes) that not only increase throughput but also enhance peptide sequence identifications: pubs.acs.org/doi/10.1021/ac… We will share results soon: parallelsq.org/workshops-and-…
Jason Derks retweeted
We have released DIA-NN 2.1.0, download link github.com/vdemichev/DiaN…, release notes github.com/vdemichev/DiaN…. It is a minor update, main highlights are: - Built-in support for Thermo .raw (Windows + Linux) - New QC metrics in PDF report & visualising trends across the experiment
Jason Derks retweeted
We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…
Jason Derks retweeted
Check out our work on identifying and providing solutions for protein leakage artifacts associated with sample preparation. It all started out with our struggle to explain a strange bi-clustering pattern in our data.
Check out our work on identifying and providing solutions for protein leakage artifacts associated with sample preparation. It all started out with our struggle to explain a strange bi-clustering pattern in our data.
Jason Derks retweeted
A new preprint: While analyzing proteomes of cells from mammalian tissues, @_AndrewLeduc identified protein leakage from permeabilized cells. We identified clear patterns that can be used to detect & mitigate this issue: biorxiv.org/content/10.110…
Jason Derks retweeted
Excited to share my PhD work investigating the regulation of my favorite X- and Y-chromosome genes! @PageLabXY
Excited to share my PhD work investigating the regulation of my favorite X- and Y-chromosome genes! @PageLabXY
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