BowTiedBiotech 🧪🔬🧬 @BowTiedBiotech
Tri-Weekly Biotech Updates: Public & Private Market Updates, Company Building, Financing, Exit Strategies, and Emerging Science Trends | Current: Biotech VC linktr.ee/bowtiedbiotech United States Joined November 2021-
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Large Pharma Has $1 Trillion of M&A Firepower Based on Latest Financials "A big recent change is that $PFE has dropped off this page following its $SGEN deal." cc: $VKTX Source: Stifel
The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.
The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.
🚨 Russell 2000 Rebalancing - April 30th $XBI
$XFOR granted Rare Pediatric Disease Priority Review Voucher (PRV) concurrent with approval
$XFOR granted Rare Pediatric Disease Priority Review Voucher (PRV) concurrent with approval
😳$22B PYS VK2735 $VKTX
EPOCH 18: BIOTECH MARKET RESEARCH $BHVN 🚨ALERT: Phase I single ascending dose (SAD) data from BHV-1300 IgG degrader program 📅DATE: 5/31 R&D day 📈📉IMPLIED VOLATILITY: +/- 50% (l!nk to substa**ck in b!o)
Your future with Price Controls Inflation Reduction Act = Innovation Reduction Act
Epoch 17: Fibrosis- From Basics to Breakthroughs 👉 Massive area of unmet need 👉 Mega-blockbuster potential 👉 Approved product landscape 👉 Competitive intensity maps 👉 Whats it worth? Deal comps (M&A & license) (l!nk to substa**ck in b!o)
BIOTECH VS. PHARMA A biotech is a pharma company that’s “unencumbered” by revenue. That can mean more focus, greater speed, and more flexibility.. ..but it can also mean fewer resources, less institutional knowledge, and more risk. Our friends in biotech find awe in the…
LIVER FIBROSIS shown in this video is a common pathophysiology leading to cirrhosis 📬Check inbox tomorrow morning for our review of therapeutic development focused on diseases fibrosis including organ systems beyond liver (lung, kidney) 😲We will touch on: Approved Products,…
😎 Pretty cool for patients to be honest. I am honestly surprised this product is just getting approved. Feels like a decade ago when this program was the talk of the gene therapy world….. $PFE How long does this last for? Is it consider a cure?
Very cool paper and thread on tcell immune response and the role of low avidity populations. 💡Similar concepts likely apply to humoral immunity?! 💡Potential relevance: vaccine design
Very cool paper and thread on tcell immune response and the role of low avidity populations. 💡Similar concepts likely apply to humoral immunity?! 💡Potential relevance: vaccine design
This is the kind of thing that drives CFOs crazy! @SecretCFO 🤯🤯🤯
This is the kind of thing that drives CFOs crazy! @SecretCFO 🤯🤯🤯
👀 I am sucker for the immune silencing…..will it deliver tbd, but super sexy engineering for sure 😍
👂 LLM in-house for drug discovery? 👍🏼 or 👎🏼 ❓ On one hand can leverage proprietary data and more accurately train the algorithms On the other hand lose scale which comes from open source ♻️REMEMBER the saying: garbage in….garbage out @ScottGottliebMD
👂 LLM in-house for drug discovery? 👍🏼 or 👎🏼 ❓ On one hand can leverage proprietary data and more accurately train the algorithms On the other hand lose scale which comes from open source ♻️REMEMBER the saying: garbage in….garbage out @ScottGottliebMD
👀 - 👁️🫷1⃣2⃣
Epoch 17: Sweat Equity - Your Weekly Biotech News Fix Designed to be consumed as a quick scroll + links to the source articles 👉 Biopharma hirings & VISAs 👉 $MRNA working with OpenAI ChatBots 👉 $BIIB PPD drug estimated $500M PYS 👉 David Baker desings peptide-like drugs 👉…
Andrew Pannu @andrewpannu
10K Followers 274 Following daily dose of biotech & healthcare commentary • founder • building software for the bioeconomy (we’re hiring software engineers!)Gator | Dentist @BowTiedGatorDDS
64K Followers 682 Following I’m the dentist that doesn’t agree with the other 9 | Not Medical Advice | Co-founder of Twitters favorite toothpaste @betterbiom 👇BowTiedOctopod | Culi.. @BowTiedOctopod
24K Followers 601 Following Inspired by @BowTiedBull | Cartoon Chef | Flavor Wizard | Latest Recipe: Making Great Pho at Home https://t.co/XZFh1c30MpCoffee @BowTiedCoffee
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16K Followers 253 Following Views=mine only, RT-like=/=endorse, no advice. 16y in Tech (chip design) & a bit of Bio :)BowTiedLoon | Degen I.. @BowTiedLoon
10K Followers 1K Following Don't take medical advice from cartoons on the internet. Inspired by @BowTiedBullBowTiedBrazil @bowtiedbrazil
6K Followers 771 Following Chad who escaped to Brazil. DM for tax optimization and strategy, offshoring, multinational taxation & corporate structuring https://t.co/OE7pB9vpllBruce Booth @LifeSciVC
50K Followers 731 Following Early stage biotech VC. Recovering scientist. Opinions expressed are solely my own and do not express the views or opinions of Atlas Venture.Yair Einhorn @yaireinhorn
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15K Followers 541 Following I return athletes to sport pain free. || Co-Founder of https://t.co/HS6l8K3R3fWei Zhao @zhaoweiasu
4K Followers 98 Following Interested in 🧬 Gene Editing: BE & PE || Science Enthusiast || Not Financial AdviceBowtied Jester @BowtiedJester
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10K Followers 379 Following Your source for the latest #Science and #Biotech news! If you're interested in #CRISPR #GeneEditing hit follow! Spaces podcast host🎙- all 20 episodes ⬇️BowTiedHalibut @bowtiedhalibut
3K Followers 1K Following Lifetime of Fishing Fresh & Salt | Healthcare Tech | Amazon FBA Biz | Inspired by @bowtiedbull and other toons. Let's go fishing.BowTiedCommoner | Hos.. @BowTiedCommoner
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428 Followers 385 Following Modernizing clinical trials by leveraging EHR interoperability and automated tools to recruit qualified candidates, reducing time-to-market for new therapeuticsJust Published @JustPubbed
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22 Followers 953 FollowingSatyabrata Bandyopadh.. @satyatifrh
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0 Followers 110 FollowingLaura Turner @lauraeturner_
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152 Followers 1K FollowingJahdavusRex @JahdavusRex
87 Followers 293 Following Think of me as a communicator and editor at the intersection of medicine, science, and the military. 🇺🇦#NAFOChaotically Science @drpepperis100
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2 Followers 79 FollowingBrad Loncar @bradloncar
69K Followers 365 Following #Biotech, Founder of @BiotechTVHQ, KC native, @univmiami hurricane.🧬🙌Biotech2k @Biotech2k1
23K Followers 738 Following Fan of #TechBio with #AI, #ML and #Automation, #CRISPR, #CellTech with #SynBio and #iPSC. I focus on #Genetics, #Immunology, #Hematology and #Oncology.BowTiedOx | Chad Body.. @BowTiedOx
70K Followers 999 Following Inspired by @BowTiedBull - The Strongest Cartoon In Crypto - Chad Scientists. - I will get you Bigger, Healthier, and Stronger. #BTC Not Medical Advice 💯Club💯Andrew Pannu @andrewpannu
10K Followers 274 Following daily dose of biotech & healthcare commentary • founder • building software for the bioeconomy (we’re hiring software engineers!)BowTiedSalesGuy @BowTiedSalesGuy
46K Followers 116 Following Inspired by @BowTiedBull. The most persuasive cartoon in Sales. Join my Free Newsletter: https://t.co/Zw440ETZWL DM for coaching/biz oppsBowTiedNightOwl @BowTiedNightOwl
28K Followers 770 Following Crypto. Finance. Memes @ https://t.co/jLsVR21zpU. | Team @bowtiedbullGator | Dentist @BowTiedGatorDDS
64K Followers 682 Following I’m the dentist that doesn’t agree with the other 9 | Not Medical Advice | Co-founder of Twitters favorite toothpaste @betterbiom 👇BowTiedOpossum | Ecom.. @BowTiedOpossum
21K Followers 129 Following Ecom & other digital stuff. Helping you get your first online business built https://t.co/p4Di4HhZYF Stay up to date👇David R. Liu @davidrliu
64K Followers 59 Following Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1BowTiedOctopod | Culi.. @BowTiedOctopod
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19K Followers 434 Following Blending cosmetic chemistry & holistic health | Co-founder of @BetterBiomCoffee @BowTiedCoffee
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198 Followers 602 Following Science Grad with a true story of swift recovery from severe post-viral illness - https://t.co/vv80bRyUqiLillian Wang Selonick @LillianSelonick
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255 Followers 1K FollowingSumeeya Rehan @SumeeyaRehan
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52 Followers 316 Following Digital Marketing /Cross Media Services/ Print ManagementHannah Nommé @nomme__
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163 Followers 544 Following Postdoc at @sedlazeck lab, HGSC, BCM Becoming a science dude, Gamer & Programmer, Zelda fanJenny Smith @LawlessJenny
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131 Followers 752 FollowingHoward Cohen @Droseco
108 Followers 839 FollowingLinda Phillips @blondie4u
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308 Followers 2K FollowingFashionWiz @FashionWiz1
536 Followers 3K Following Clothing and Fashion Apparel for Women and Men. The latest styles and trends for men's and women's fashion, shoes, jewelry, and accessories.PHalat @palatheter
157 Followers 337 Following The moonlight account: Shenanigans, games, sports, cars, memes and a cheeky bit of science. He/TheyDavid Matějček @dmatej
262 Followers 325 Following Curious Jakarta EE + GlassFish developer, co-owner of https://t.co/BzMgzpfYVl, bug hunter, zombie killer. Loves science.Anuj @unuj
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58 Followers 462 Following Design researcher @IBM. ex @ideas42. @Stanford alumnus. Behavioral science / Design / TechBrandon @BrandonMillikin
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312 Followers 61 Following Development stage, private biotech co. focused on personalized IPSC (autologous) cell therapies to address unmet medical needs, starting with Parkinson's (PD)Aneliya Vasileva, Pha.. @aneliyavasileva
200 Followers 1K Following Primary Care/Community #pharmacist in London, Ontario, 🇨🇦, #UWPharmacy, HBSc in Biotech and Gen. Eng. from McMaster University #TwitteRxMunmee_UT @munmee_UT
55 Followers 461 Following Postdoctoral researcher, Cancer genome researcher, NGS data analyst, Computational biologist, Data Science | PhD, The University of TokyoHopefully we finally get good data for IO beyond Pd1s. IO in cold tumors is a huge unmet need.
@BowTiedBiotech More than enough to buy $vktx
@BowTiedBiotech Glaring omission in $MRK
@BowTiedBiotech I think $PFE $BMY $ABBV won’t go for larger size deals anytime soon as they did large sum of transactions. However, all the other big pharma still has a ton of cash.
The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.
We are pleased to announce that #FDA has cleared our IND application for PM359 for the treatment of chronic granulomatous disease (CGD), enabling Prime to initiate its Phase 1/2 clinical trial in the US. Details: investors.primemedicine.com/news-releases/… $PRME
$XFOR granted Rare Pediatric Disease Priority Review Voucher (PRV) concurrent with approval
$XFOR Announces FDA Approval of XOLREMDI (mavorixafor) Capsules, First Drug Indicated in Patients with WHIM Syndrome
The blatantly obvious answer - Japan price controls annihilate any successful drugs. If Democrats continue to think with no logic, same will be true in the US soon. trinitylifesciences.com/blog/japans-la…
BIOTECH VS. PHARMA A biotech is a pharma company that’s “unencumbered” by revenue. That can mean more focus, greater speed, and more flexibility.. ..but it can also mean fewer resources, less institutional knowledge, and more risk. Our friends in biotech find awe in the…
@BowTiedBiotech Fixin’ to drink some Wild Turkey now.
@BowTiedBiotech If I’m not mistaken $PFE bought the asset from Spark therapeutics which also developed Luxturna - the first ever @US_FDA approved Ocular Gene therapy aimed to treat an inherited retinal disease (IRD) caused due to mutations in both copies of the RPE65 gene.
Cowen Very important slide about company engagement in different categories It could be a roadmap for future acquisions
Cowen - excellent slide showing big pharma - still dominated in cancer-cardiology-neuro- #OBESITY only by 2-3 yet market bigger then statins - will be interesting to see how this slide changes in next 10 years $XBI $IBB $LLY $MRK $NVO $PFE $BMY $REGN $VKTX
@BowTiedBiotech Majority in onco are early asset deals and hence the low value
@BowTiedBiotech @ScottGottliebMD Some conflicts of interest here ...
@BowTiedBiotech The government is choosing inflation rather than growth currently. I've spoken to a few about CHIPS Act and regulation and hoops are making it a waste of funds so far.
@BowTiedBiotech And what you do in development is crucial. Genentech invented molecules, Roche developed amazing drugs (just compare Genentech and Roche trial success e.g. pertuzumab).
@BowTiedBiotech Would say that Externally sourced will still have a large segment in the upcoming years. There is a very unique aspect about young startups specifically and the fast pacing culture that enable great technologies to be developed in speeds that big corporations can’t comprehend.
Pfizer is _commercializing_ this therapy. It was _developed_ by Spark Therapeutics under the leadership of Dr Katherine High @PennMedicine. She also built Luxturna - the first approved AAV medicine. Dr High is a hero and inspiration to all working in our field. #WomenInSTEM
Pfizer’s first gene therapy, a $3.5 million one-time treatment for hemophilia B, enters a market that has vexed other drugmakers bloomberg.com/news/articles/… $pfe
@BowTiedBiotech Cheap energy via 4th Gen nuclear. Manufacturing boom would follow. Government spending is trickier. Taxes need to have gradual. I align more with Piketty on this. Low interest but not too low (1 tree principle)
Proud to share that the @BioPharmaDive team has won Jesse H. Neal Awards for Best Industry Coverage and Best Series! Reporter @gwendolynawu was also -- very deservedly -- selected as the 2024 McAllister Editorial Fellow: siia.net/siia-media-ann…