avidresearch @avidresearch
Joined October 2009-
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First disease modifying and first RNAi editing drug now enrolling AATD participants and market is like MEH. $WVE
First disease modifying and first RNAi editing drug now enrolling AATD participants and market is like MEH. $WVE
Hopefully we finally get good data for IO beyond Pd1s. IO in cold tumors is a huge unmet need.
Pan-her2. This drug is incredible.
Pan-her2. This drug is incredible.
Damn! Finally $PRME is no longer a lab and is now in clinical trials.
Damn! Finally $PRME is no longer a lab and is now in clinical trials.
Weirdly is this good for $gern? Not directly related but it will be in heme space.
Weirdly is this good for $gern? Not directly related but it will be in heme space.
Interesting to see if other IL-2 players will move. IO space valuation completely subdued (rightful so after all the targets that went dud).
Interesting to see if other IL-2 players will move. IO space valuation completely subdued (rightful so after all the targets that went dud).
Interesting move! No discount... at a price of CA$1.95 per share $MDNAF $MDNA.to Medicenna Therapeutics Announces CA$20 Million Investment from RA Capital Management globenewswire.com/news-release/2…
Two exciting studies out in @Nature show that high tumor PGE2 limits IL-2 sensing and antitumor function in TIL. Disrupting this axis can potently enhance antitumor responses. Nice work @CoukosGeorge @JBoettcherLab and teams! nature.com/articles/s4158… nature.com/articles/s4158…
IL-2 been dead after $NKTR disaster (market reaction to IL2 been nada). Plenty of companies trying for next gen IL-2. Some data from PROCLAIMSM national patient registry pointing to potential synergies of a safe and effective IL-2 with PD1. $MDNAF $HOWL $XLO
Opdualag Lag-3 almost a blockbuster based on just one indication (melanoma). Data from NSCLC overdue. Hopefully we see it soon. $BMY
Anyone seen $BMY lag-3 data for NSCLC. They indicate POC achieved.
Anyone seen $BMY lag-3 data for NSCLC. They indicate POC achieved.
Always thought moon shot was all hype but what this man has done for undruggable RAS/KRAS targets (30% of all cancers) makes me optimistic about the moonshot.
Always thought moon shot was all hype but what this man has done for undruggable RAS/KRAS targets (30% of all cancers) makes me optimistic about the moonshot.
$BMY overpaid. KRAS landscape changing rapidly.
Hope this is a double top !
Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers [Mar 23, 2022] @SalemGIOncDoc et al. @JCOPO_ASCO ow.ly/PpPS50IK2QH #ImmunoOnc #PrecisionMedicine
$DAWN great drug. Front line study design (sample size) could be updated per management comments recently. Any clarity on that and the probability of success for frontline likely needed for M&A prospects.
#ASCO24 Abstract Titles, including LBAs, Released online: April 24, 2024, at 10:00 AM (ET)
Interesting new IO target? CCR8.
A sharp look at an emerging onco niche we're likely to hear much more about going forward - who will be the fortunate ones? bit.ly/3w1KsVD
Pharmdca @Pharmdca
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321K Followers 58 Following Become the best version of yourself. DM to boost your brand.@avidresearch @JacobPlieth Gotcha, I would caution on this — none are primary PD-1 resistant responses which makes the pop quite heterogenous in re-treatment benefit, and small n=2/6. MK-4830 ILT4 had cORR (5/11) in PD-1 experienced, unlikely it was reproduced—silence since.
Unclear on when reads out given its event driven but IgG4-RD trial (“MITIGATE”) very interesting as well. Huge unmet need there ncbi.nlm.nih.gov/pmc/articles/P… clinicaltrials.gov/study/NCT04540… $AMGN $ELYM $CGEM
There are TWO Phase 3 trials for CD19 mAb inebilizumab in autoimmune disease reading out 𝑻𝑯𝑰𝑺 𝒀𝑬𝑨𝑹 MG classic.clinicaltrials.gov/ct2/show/NCT04… SSc classic.clinicaltrials.gov/ct2/show/NCT05… I expect SSc to work. MG tougher call for me. $AMGN $ELYM $CGEM
$LLY has bad structured pipeline. To fix thet they may need to buy early stage companies with novel technologies I have a few suggestion to help them $RVMD (RAS ON) $NUVL (ROS, ALK) $KYMR (TPD) Other suggestions welcome
@BowTiedBiotech Wouldn't be surprised to see them buying early stage companies with novel technologies like $RVMR (RAS ON) $NUVL (ROS, ALK), $KYMR (TPD) or all of the above🙂
$CUE (<$50m EV) also has an anti-CD19 TCE program they suggest has distinctive advantages over $ELYM $CABA and $CGEM 🤔 Maybe we'll get an update with their upcoming Q1 results?
$ELYM > or = $ALPN in PMN?! very small n obvi but just sayin nice initial data from $ELYM with PMN update later this year... non cell tx* CD19 I&I is 🔥🔥🔥 *emphasis on non cell tx, pls stop w/ this. thx.
$LBPH TAM 6B They has 58% seizure reduction better than competitors (Fintepla - $UCB, Epidiolex - $JAZZ) LBPH MC is 840M cash 270M Last capital raise in Jan at $21 Relevant acquisitions in the field JAZZ - GW $7.2B PFE - ARNA $6.7B UCB - ZGNX $1.9B 5x is reasonable return IMO
$LBPH Baird PT 36 DEE epilepsy. Ph 2 completed successfully To start Ph 3 in H2 Plus OLE data in H2
$LYRA -- Phase 3 Results from ENLIGHTEN 1 Trial of LYR-210 in Chronic Rhinosinusitis (CRS) Expected in May -- investors.lyratherapeutics.com/news-releases/…
Figure 21B seems to be the killer figure. The crosslinking PSMA mAb variant is 1000x more potent than the non-cross linking mAb.
Here is the cool covalent cross linking mAb platform. First patent is here. FSY seems to be the covalent linker target receptor. Super cool idea. patents.google.com/patent/WO20232…
Incubated by Avalon Ventures, 3 y.o. San Diego biotech Enlaza is heading toward the clinic with $161M in funding & a platform with which it could create the 1st covalent biologic drugs. @BioBonanos speaks with CEO Sergio Duron in @BioCentury
This CD19 revival reminds me of $VERA Atacicept around for a long time. Small trial with idiosyncratic (and ultimately just unlucky) tox signals caused pessimism and doubt about utility. Inebilizumab likely a very good therapy, but pigeon holed early. $elym $cgem
Unpopular opinion, but I don’t think the muscle saving obesity drugs will do well. If you’re not losing muscle, you’re not losing as much weight. I understand the concept, but I believe it will be a tough sell to convince people that losing less weight is the better option.
60 Minutes $NVDA Jensen Huang youtube.com/watch?v=DpQQi2…
For IPF, missing @PrezCamacho's company Endeavor. ENV-101 in phase 2. endeavorbiomedicines.com/our-science/pi…
IPF and depression landscapes from GS' initiation report on $CTNM
$BBIO MGT remained optimistic acoramidis would be able to make significant inbounds, reaching multi-billion in peak sales potential.
HOTKEYS AND THE COST OF PRICE SLIPPAGE A few times now it has come up how critical hotkeys were to my trading. Many were astounded to learn that I virtually never used the mouse bc of how slow it is. Many of the replies have made the argument that hotkeys aren’t relevant to…
More evidence of a big downward correction for value of Ivy League degrees. Other private schools aren't simialry affected. x.com/johnarnoldfndt…
Now confirmed with data. Forbes surveyed managers with hiring authority. When asked whether more/less likely to hire vs 5 years ago: Ivy League: 7% more likely; 33% say less likely Public univs: 42% more likely; 5% less likely Selective privates: 37% more likely; 5% less likely
$prme not really surprised by regulatory success here. David Liu and Marks have been having a platonic love affair ♥️ endlessly cross-referencing each other at conferences. What Prime is hoping for is that 1 IND can be used as a platform template for future filings. US…
No doubt and thanks for the shoutout Lance. If I had an hour I would’ve used it in Vegas but the premise was that hotkeys indeed are an advantage that people sleep on. It’s very clear for people with gaming backgrounds (@TheOneLanceB used to play Dota also!) because you could…
HOTKEYS AND THE COST OF PRICE SLIPPAGE A few times now it has come up how critical hotkeys were to my trading. Many were astounded to learn that I virtually never used the mouse bc of how slow it is. Many of the replies have made the argument that hotkeys aren’t relevant to…
Big 3-6 months ahead for us at @TradeZella - doubling our engineering team (our team right now with current growth is extremely small, and i didn’t plan properly for this) - massive updates/ improvements to the backtesting feature - new reports/ insights being worked on -…